A novel animal model for in vivo study of liver cancer metastasis.

Fujiwara S, Fujioka H, Tateno C, Taniguchi K, Ito M, Ohishi H, Utoh R, Ishibashi H, Kanematsu T, Yoshizato K.
World J Gastroenterol. 2012 Aug 7;18(29):3875-82.

Investigation of Drug-drug Interactions Caused by Human Pregnane X Receptor-mediated Induction of Cytochrome P450 3A4 and 2C Subfamilies in Chimeric Mice with a Humanized Liver.

Hasegawa M, Tahara H, Inoue R, Kakuni M, Tateno C, Ushiki J.
Drug Metab Dispos. 2012 40(3)474-480

Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
Drug Metab Dispos. 2011 40(2)322-8

Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes.

Sanoh S, Nozaki K, Murai H, Terashita S, Teramura T, Ohta S.
Drug Metab Dispos. 2011 40(1)76-82

Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.

Schulz-Utermoehl T, Sarda S, Foster JR, Jacobsen M, Kenna JG, Morikawa Y, Salmu J, Gross G, Wilson ID.
Xenobiotica.　2012 Jun;42(6):503-17.

Novel cell culture-adapted genotype 2a hepatitis C virus infectious clone.

Date T, Kato T, Kato J, Takahashi H, Morikawa K, Akazawa D, Murayama A, Tanaka-Kaneko K, Sata T, Tanaka Y, Mizokami M, Wakita T.
J Virol. 2012 Oct;86(19):10805-20.

Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes.

Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Uramaru N, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
Drug Metab Dispos. 2012 Dec;40(12):2267-72.

Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

Masakazu Kakuni, Mayu Morita, Kentaro Matsuo, Yumiko Katoh, Miki Nakajima,Chise Tateno, Tsuyoshi Yokoi
Toxicology Letters 214 (2012) 9-18

Differential Effect of Troglitazone on the Human Bile Acid Transporters, MRP2 and BSEP, in the PXB Hepatic Chimeric Mouse

Foster JR, Jacobsen M, Kenna G, Schulz-Utermoehl T, Morikawa Y, Salmu J, Wilson ID.
Toxicologic Pathology, 2012 Dec;40(8):1106-16.

Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

Samuelsson K, Pickup K, Sarda S, Swales JG, Morikawa Y, Schulz-Utermoehl T, Hutchison M, Wilson ID.
Xenobiotica. 2012 Nov;42(11):1128-37.

Mice with liver composed of human hepatocytes as an animal model for drug testing.

Yoshizato K, Tateno C, Utoh R.

Curr Drug Discov Technol. 2012 Mar;9(1):63-76. Review.

Chimeric mice with humanized liver: mechanism of hepatic hyperplasia induction.

Tateno C.

生化学　2012 Aug;84(8):699-706.

Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication.

Chayama K, Hayes CN, Imamura M.
Hepatol Res. 2012 Sep;42(9):841-53.

ヒト肝細胞キメラマウスを用いた抗肝炎ウイルス薬効評価系

加国雅和、立野知世

ファルマシア 2012; 48(10): 956-958

Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse.

Okazaki A, Hiraga N, Imamura M, Nelson Hayes C, Tsuge M, Takahashi S, Aikata H, Abe H, Miki D, Ochi H, Tateno C, Yoshizato K, Ohdan H, Chayama K.
Hepatology. 2012 Aug;56(2):555-66.

An orally available, small-molecule interferon inhibits viral replication

Hideyuki Konishi, Koichi Okamoto, Yusuke Ohmori, Hitoshi Yoshino, Hiroshi Ohmori, Motooki Ashihara, Yuichi Hirata, Atsunori Ohta, Hiroshi Sakamoto, Natsuko Hada, Asao Katsume, Michinori Kohara, Kazumi Morikawa, Takuo Tsukuda, Nobuo Shimma, Graham R. Foster, William Alazawi, Yuko Aoki, Mikio Arisawa & Masayuki Sudoh
Scientific Reports Volume: 2,Article number:259

Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor.

Sainz B Jr, Barretto N, Martin DN, Hiraga N, Imamura M, Hussain S, Marsh KA, Yu X, Chayama K, Alrefai WA, Uprichard SL.
Nat Med. 2012 Jan 8;18(2):281-5

Evaluation of combination therapy against hepatitis C virus infection in human liver chimeric mice

Ype P. de Jong1,2, Charles M. Rice1, Alexander Ploss1,

J Hepatol.2011; 54:848–850

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton’s tyrosine kinase inhibitor.

Liu L, Halladay JS, Shin Y, Wong S, Coraggio M, La H, Baumgardner M, Le H, Gopaul S, Boggs J, Kuebler P, Davis JC Jr, Liao XC, Lubach JW, Deese A, Sowell CG, Currie KS, Young WB, Khojasteh SC, Hop CE, Wong H.
Drug Metab Dispos. 2011 Oct;39(10):1840-9.

Impact of viral amino acid substitutions and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C virus.

Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, Tateno C, Yoshizato K, Nakamura Y, Kamatani N, Chayama K.
Hepatology. 2011 Sep 2;54(3):764-71.