Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo.

Hiraga N, Imamura M, Abe H, Hayes CN, Kono T, Onishi M, Tsuge M, Takahashi S, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, Matsui H, Kanai A, Inaba T, Tanaka S, Chayama K.
Hepatology. 2011 Sep 2;54(3):781-8.

Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.

Takano T, Tsukiyama-Kohara K, Hayashi M, Hirata Y, Satoh M, Tokunaga Y, Tateno C, Hayashi Y, Hishima T, Funata N, Sudo M, Kohara M.

J Hepatol. 2011 Sep;55(3):512-21

An experimental mouse model for hepatitis C virus.

Kimura K, Kohara M.

Exp Anim. 2011;60(2):93-100. Review.

Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice.

Tsuge M, Takahashi S, Hiraga N, Fujimoto Y, Zhang Y, Mitsui F, Abe H, Kawaoka T, Imamura M, Ochi H, Hayes CN, Chayama K.
J Infect Dis. 2011 Jul 15;204(2):224-8.

ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo.

Abe H, Imamura M, Hiraga N, Tsuge M, Mitsui F, Kawaoka T, Takahashi S, Ochi H, Maekawa T, Hayes CN, Tateno C, Yoshizato K, Murakami S, Yamashita N, Matsuhira T, Asai K, Chayama K.
J Hepatol. 2011 Jul;55(1):11-8. Epub 2010 Nov 29.

Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism.

De Serres M, Bowers G, Boyle G, Beaumont C, Castellino S, Sigafoos J, Dave M, Roberts A, Shah V, Olson K, Patel D, Wagner D, Yeager R, Serabjit-Singh C.
Xenobiotica. 2011 Jun;41(6):464-75.

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.

Lupberger J, Zeisel MB, Xiao F, Thumann C, Fofana I, Zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D, Fresquet J, Cosset FL, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P, Doffoël M, Raffelsberger W, Poch O, McKea
Nat Med. 2011 May;17(5):589-95.

Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice.

Ohara E, Hiraga N, Imamura M, Iwao E, Kamiya N, Yamada I, Kono T, Onishi M, Hirata D, Mitsui F, Kawaoka T, Tsuge M, Takahashi S, Abe H, Hayes CN, Ochi H, Tateno C, Yoshizato K, Tanaka S, Chayama K.
J Hepatol. 2011 May;54(5):872-8

Growth hormone-dependent pathogenesis of human hepatic steatosis in a novel mouse model bearing a human hepatocyte-repopulated liver.

Tateno C, Kataoka M, Utoh R, Tachibana A, Itamoto T, Asahara T, Miya F, Tsunoda T, Yoshizato K.
Endocrinology. 2011 Apr;152(4):1479-91.

Transmissibility of hepatitis B virus (HBV) infection through blood transfusion from blood donors with occult HBV infection.

Yuen MF, Wong DK, Lee CK, Tanaka Y, Allain JP, Fung J, Leung J, Lin CK, Sugiyama M, Sugauchi F, Mizokami M, Lai CL.
Clin Infect Dis. 2011 Mar;52(5):624-32

Cross-species transmission of gibbon and orangutan hepatitis B virus to uPA/SCID mice with human hepatocytes.

Sa-Nguanmoo P, Tanaka Y, Ratanakorn P, Sugiyama M, Murakami S, Payungporn S, Sommanustweechai A, Mizokami M, Poovorawan Y.
Virus Res. 2011 Jun;158(1-2):209-15

PBXマウス由来新鮮肝細胞を用いたインビトロ代謝試験

安達弥長

HAB Newsleter 2011; 18(1): 21-23

Morphologic characterization of PhoenixBio (uPA+/+/SCID) humanized liver chimeric mouse model.

Peterson RA, Krull DL, Brown HR, de Serres M.

Drug Metab Lett. 2010 Aug;4(3):180-184.

HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice.

Tsuge M, Hiraga N, Akiyama R, Tanaka S, Matsushita M, Mitsui F, Abe H, Kitamura S, Hatakeyama T, Kimura T, Miki D, Mori N, Imamura M, Takahashi S, Hayes CN, Chayama K.

J Gen Virol. 2010 Jul;91(Pt 7):1854-64.

Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants.

Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M.

Virology. 2010 Sep 30;405(2):361-9.

Positive selection of core 70Q variant genotype 1b hepatitis C virus strains induced by pegylated interferon and ribavirin.

Kurbanov F, Tanaka Y, Matsuura K, Sugauchi F, Elkady A, Khan A, Hasegawa I, Ohno T, Tokuda H, Mizokami M.

J Infect Dis. 2010 Jun 1;201(11):1663-71

Animal model for study of human hepatitis viruses.

Chayama K, Hayes CN, Hiraga N, Abe H, Tsuge M, Imamura M.
J Gastroenterol Hepatol. 2011 Jan;26(1):13-8

C型肝炎感染を起こすタンパク質

中国新聞

Assessment of chimeric mice with humanized liver as a tool for predicting circulating human metabolites.

Kamimura H, Nakada N, Suzuki K, Mera A, Souda K, Murakami Y, Tanaka K, Iwatsubo T, Kawamura A, Usui T.

Drug Metab Pharmacokinet. 2010;25(3):223-35.

Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.

Kikuchi R, McCown M, Olson P, Tateno C, Morikawa Y, Katoh Y, Bourdet DL, Monshouwer M, Fretland AJ.
Drug Metab Dispos. 2010 Nov;38(11):1954-61.