CYP1A1 and CYP1A2 expression: comparing ‘humanized’ mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines.

Uno S, Endo K, Ishida Y, Tateno C, Makishima M, Yoshizato K, Nebert DW.
Toxicol Appl Pharmacol. 2009 May 15;237(1):119-26.

Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes.

Sugiyama M, Tanaka Y, Kurbanov F, Maruyama I, Shimada T, Takahashi S, Shirai T, Hino K, Sakaida I, Mizokami M.
Gastroenterology. 2009 Feb;136(2):652-62

ヒト肝キメラマウスの特性

特免編集部

シリーズIII: 継続・肝炎ウイルス十話＿第一話

Prediction of Human Disposition toward S-3H-Warfarin using Chimeric Mice with Humanized Liver

Tae INOUE, Kazumi SUGIHARA, Hiroki OHSHITA, Toru HORIE, Shigeyuki KITAMURA and Shigeru OHTA
Drug Metabolism and Pharmacokinetics Vol. 24 (2009) , No. 2 pp.153-160

Titration of hepatitis B virus infectivity in the sera of pre-acute and late acute phases of HBV infection: transmission experiments to chimeric mice with human liver repopulated hepatocytes.

Tabuchi A, Tanaka J, Katayama K, Mizui M, Matsukura H, Yugi H, Shimada T, Miyakawa Y, Yoshizawa H.
J Med Virol. 2008 Dec;80(12):2064-8.

CYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized Liver.

Inoue T, Nitta K, Sugihara K, Horie T, Kitamura S, Ohta S.
Drug Metab Dispos. 2008 Dec;36(12):2429-2433

Molecular epidemiology and interferon susceptibility of the natural recombinant hepatitis C virus strain RF1_2k/1b.

Kurbanov F, Tanaka Y, Chub E, Maruyama I, Azlarova A, Kamitsukasa H, Ohno T, Bonetto S, Moreau I, Fanning LJ, Legrand-Abravanel F, Izopet J, Naoumov N, Shimada T, Netesov S, Mizokami M.
J Infect Dis. 2008 Nov 15;198(10):1448-56.

Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.

Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Takeda K, Utsunomiya H, Oda K, Warabi E, Ishii T, Osaka K, Hyodo I, Yamamoto M.
Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G735-47. Epub 2008 Aug 7.

Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice.

Kimura T, Imamura M, Hiraga N, Hatakeyama T, Miki D, Noguchi C, Mori N, Tsuge M, Takahashi S, Fujimoto Y, Iwao E, Ochi H, Abe H, Maekawa T, Arataki K, Tateno C, Yoshizato K, Wakita T, Okamoto T, Matsuura Y, Chayama K.
J Gen Virol. 2008 Sep;89(Pt 9):2108-13.

Aldehyde oxidase-catalyzed metabolism of N1-methylnicotinamide in vivo and in vitro in chimeric mice with humanized liver.

Kitamura S, Nitta K, Tayama Y, Tanoue C, Sugihara K, Inoue T, Horie T, Ohta S.
Drug Metab Dispos. 2008 Jul;36(7):1202-5

Characteristics of hepatitis B virus genotype G coinfected with genotype H in chimeric mice carrying human hepatocytes.

Tanaka Y, Sanchez LV, Sugiyama M, Sakamoto T, Kurbanov F, Tatematsu K, Roman S, Takahashi S, Shirai T, Panduro A, Mizokami M.
Virology. 2008 Jul 5;376(2):408-15. Epub 2008 May 13.

Human hepatocytes can repopulate mouse liver: histopathology of the liver in human hepatocyte-transplanted chimeric mice and toxicologic responses to acetaminophen.

Sato Y, Yamada H, Iwasaki K, Tateno C, Yokoi T, Yoshizato K, Horii I.
Toxicol Pathol. 2008;36(4):581-91.

ヒト肝細胞キメラマウスにおける血中ヒトアルブミン値と血清尿酸値の相関性

安西 尚彦　加国 雅和 大房 健　遠藤 仁
Gout and Nucleic Acid Metabolism 2008; 32: 13-18

Successful in vivo propagation of factor IX-producing hepatocytes in mice: Potential for cell-based therapy in haemophilia B.

Tatsumi K, Ohashi K, Kataoka M, Tateno C, Shibata M, Naka H, Shima M, Hisanaga M, Kanehiro H, Okano T, Yoshizato K, Nakajima Y, Yoshioka A.
Thromb Haemost. 2008;99(5):883-891.

Chimeric mice with humanized liver.

Katoh M, Tateno C, Yoshizato K, Yokoi T.
Toxicology. 2008 Apr 3;246(1):9-17.

Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver

Emoto C, Yamato Y, Sato Y, Ohshita H, Katoh M, Tateno C, Yokoi T, Yoshizato K, Iwasaki K.
Xenobiotica. 2008 Mar;38(3):239-48.

Susceptibility of chimeric mice with livers repopulated by serially subcultured human hepatocytes to hepatitis B virus.

Utoh R, Tateno C, Yamasaki C, Hiraga N, Kataoka M, Shimada T, Chayama K, Yoshizato K.
Hepatology. 2008 Feb;47(2):435-46.

キメラマウス肝細胞の薬物代謝能に関して

内藤真策、吉次博紀

細胞：（特集　ヒト細胞キメラマウスの医学・薬学利用）2008；40（1）：36-41

キメラマウスにおけるKetoprofenのin vivo代謝試験

橋爪研太、大曽根義安、安達弥長、二宮真一、井上多恵、堀江透

細胞：（特集　ヒト細胞キメラマウスの医学・薬学利用）2008；40（1）：26-29

ヒト肝前駆細胞を用いたキメラマウス

鵜頭理恵、立野知世、吉里勝利

細胞：（特集　ヒト細胞キメラマウスの医学・薬学利用）2008；40（1）：17-21