Phoenix Bio

研究開発

研究開発

HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-beta type I receptor

    Sakata, K. Hara, M. Terada, T. Watanabe, N. Takaya, D. Yaguchi, S. Matsumoto, T. Matsuura, T. Shirouzu, M. Yokoyama, S. Yamaguchi, T. Miyazawa, K. Aizaki, H. Suzuki, T. Wakita, T. Imoto, M. Kojima, S.
    Sci Rep. 2013 Nov 22;3:3243. doi: 10.1038/srep03243.

    Transplantation of engineered chimeric liver with autologous hepatocytes and xenobiotic scaffold

      Hata T, Uemoto S, Fujimoto Y, Murakami T, Tateno C, Yoshizato K, Kobayashi E.
      Ann Surg. 2013 Mar;257(3):542-7.

      Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene.

        Watanabe T, Sugauchi F, Tanaka Y, Matsuura K, Yatsuhashi H, Murakami S, Iijima S, Iio E, Sugiyama M, Shimada T, Kakuni M, Kohara M, Mizokami M.
        Gut. 2013 Sep;62(9):1340-6

        Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection.

          Nakagawa S, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M.
          PLoS One. 2013;8(3):e59611.

          Thromboxane A2 Synthase Inhibitors Prevent Production of Infectious Hepatitis C Virus in Mice with Humanized Livers.

            Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chayama K, Hijikata M
            Gastroenterology. 2013 Sep;145(3):658-67.e11.

            A Serine Palmitoyltransferase Inhibitor Inhibits Hepatitis C Virus Replication in Human Hepatocytes.

              Katsume A, Tokunaga Y, Hirata Y, Munakata T, Saito M, Hayashi H, Okamoto K, Ohmori Y, Kusanagi I, Fujiwara S, Tsukuda T, Aoki Y, Klumpp K, Tsukiyama-Kohara K, El-Gohary A, Sudoh M, Kohara M.
              Gastroenterology. 2013 Oct;145(4):865-73.

              Demonstration of hepatitis C virus RNA with in situ hybridization employing a locked nucleic Acid probe in humanized liver of infected chimeric mice and in needle-biopsied human liver.

                Shiogama K, Inada K, Kohara M, Teramoto H, Mizutani Y, Onouchi T, Tsutsumi Y.
                Int J Hepatol. 2013;2013:249535. doi: 10.1155/2013/249535. Epub 2013 Jun 18.

                Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice.

                  Shi N, Hiraga N, Imamura M, Hayes CN, Zhang Y, Kosaka K, Okazaki A, Murakami E, Tsuge M, Abe H, Aikata H, Takahashi S, Ochi H, Tateno-Mukaidani C, Yoshizato K, Matsui H, Kanai A, Inaba T, McPhee F, Gao M, Chayama K.
                  Gut. 2013 Jul;62(7):1055-61

                  A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?

                    Yoshizato, K. Tateno, C.

                    Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1419-35.

                    Neutralizing antibodies induced by cell culture-derived hepatitis C virus protect against infection in mice

                      Akazawa D, Moriyama M, Yokokawa H, Omi N, Watanabe N, Date T, Morikawa K, Aizaki H, Ishii K, Kato T, Mochizuki H, Nakamura N, Wakita T
                      Gastroenterology. 2013 Aug;145(2): 447-455.

                      Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes.

                        Tanoue C, Sugihara K, Uramaru N, Tayama Y, Watanabe Y, Horie T, Ohta S, Kitamura S
                        Xenobiotica. 2013 Nov;43(11):956-62.

                        Synthetic lipophilic antioxidant BO-653 suppresses HCV replication.

                          Yasui F, Sudoh M, Arai M, Kohara M.
                          J Med Virol. 2013 Feb;85(2):241-9.

                          Morphological and microarray analyses of human hepatocytes from xenogeneic host livers

                            Chise Tateno, Fuyuki Miya, Kenjiro Wake, Miho Kataoka, Yuji Ishida, Chihiro Yamasaki, Ami Yanagi, Masakazu Kakuni, Eddie Wisse, Fons Verheyen, Kouji Inoue, Kota Sato, Atsushi Kudo, Shigeki Arii, Toshiyuki Itamoto, Toshimasa Asahara, Tatsuhiko Tsunoda and Katsutoshi Yoshizato
                            Lab Invest. 2013 Jan;93(1):54-71.

                            Liver tissue engineering utilizing hepatocytes propagated in mouse livers in vivo.

                              Ohashi K, Tatsumi K, Tateno C, Kataoka M, Utoh R, Yoshizato K, Okano T.
                              Cell Transplant. 2012;21(2-3):429-36.

                              Human hepatocyte propagation system in the mouse livers: functional maintenance of the production of coagulation and anticoagulation factors.

                                Tatsumi K, Ohashi K, Tateno C, Yoshizato K, Yoshioka A, Shima M, Okano T.
                                Cell Transplant. 2012;21(2-3):437-45.

                                A novel animal model for in vivo study of liver cancer metastasis.

                                  Fujiwara S, Fujioka H, Tateno C, Taniguchi K, Ito M, Ohishi H, Utoh R, Ishibashi H, Kanematsu T, Yoshizato K.
                                  World J Gastroenterol. 2012 Aug 7;18(29):3875-82.

                                  Investigation of Drug-drug Interactions Caused by Human Pregnane X Receptor-mediated Induction of Cytochrome P450 3A4 and 2C Subfamilies in Chimeric Mice with a Humanized Liver.

                                    Hasegawa M, Tahara H, Inoue R, Kakuni M, Tateno C, Ushiki J.
                                    Drug Metab Dispos. 2012 40(3)474-480

                                    Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

                                      Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
                                      Drug Metab Dispos. 2011 40(2)322-8

                                      Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes.

                                        Sanoh S, Nozaki K, Murai H, Terashita S, Teramura T, Ohta S.
                                        Drug Metab Dispos. 2011 40(1)76-82

                                        Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.

                                          Schulz-Utermoehl T, Sarda S, Foster JR, Jacobsen M, Kenna JG, Morikawa Y, Salmu J, Gross G, Wilson ID.
                                          Xenobiotica. 2012 Jun;42(6):503-17.