Phoenix Bio

研究開発

研究開発

Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice.

    Shi N, Hiraga N, Imamura M, Hayes CN, Zhang Y, Kosaka K, Okazaki A, Murakami E, Tsuge M, Abe H, Aikata H, Takahashi S, Ochi H, Tateno-Mukaidani C, Yoshizato K, Matsui H, Kanai A, Inaba T, McPhee F, Gao M, Chayama K.
    Gut. 2013 Jul;62(7):1055-61

    A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?

      Yoshizato, K. Tateno, C.

      Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1419-35.

      Neutralizing antibodies induced by cell culture-derived hepatitis C virus protect against infection in mice

        Akazawa D, Moriyama M, Yokokawa H, Omi N, Watanabe N, Date T, Morikawa K, Aizaki H, Ishii K, Kato T, Mochizuki H, Nakamura N, Wakita T
        Gastroenterology. 2013 Aug;145(2): 447-455.

        Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes.

          Tanoue C, Sugihara K, Uramaru N, Tayama Y, Watanabe Y, Horie T, Ohta S, Kitamura S
          Xenobiotica. 2013 Nov;43(11):956-62.

          Synthetic lipophilic antioxidant BO-653 suppresses HCV replication.

            Yasui F, Sudoh M, Arai M, Kohara M.
            J Med Virol. 2013 Feb;85(2):241-9.

            Morphological and microarray analyses of human hepatocytes from xenogeneic host livers

              Chise Tateno, Fuyuki Miya, Kenjiro Wake, Miho Kataoka, Yuji Ishida, Chihiro Yamasaki, Ami Yanagi, Masakazu Kakuni, Eddie Wisse, Fons Verheyen, Kouji Inoue, Kota Sato, Atsushi Kudo, Shigeki Arii, Toshiyuki Itamoto, Toshimasa Asahara, Tatsuhiko Tsunoda and Katsutoshi Yoshizato
              Lab Invest. 2013 Jan;93(1):54-71.

              Liver tissue engineering utilizing hepatocytes propagated in mouse livers in vivo.

                Ohashi K, Tatsumi K, Tateno C, Kataoka M, Utoh R, Yoshizato K, Okano T.
                Cell Transplant. 2012;21(2-3):429-36.

                Human hepatocyte propagation system in the mouse livers: functional maintenance of the production of coagulation and anticoagulation factors.

                  Tatsumi K, Ohashi K, Tateno C, Yoshizato K, Yoshioka A, Shima M, Okano T.
                  Cell Transplant. 2012;21(2-3):437-45.

                  A novel animal model for in vivo study of liver cancer metastasis.

                    Fujiwara S, Fujioka H, Tateno C, Taniguchi K, Ito M, Ohishi H, Utoh R, Ishibashi H, Kanematsu T, Yoshizato K.
                    World J Gastroenterol. 2012 Aug 7;18(29):3875-82.

                    Investigation of Drug-drug Interactions Caused by Human Pregnane X Receptor-mediated Induction of Cytochrome P450 3A4 and 2C Subfamilies in Chimeric Mice with a Humanized Liver.

                      Hasegawa M, Tahara H, Inoue R, Kakuni M, Tateno C, Ushiki J.
                      Drug Metab Dispos. 2012 40(3)474-480

                      Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

                        Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
                        Drug Metab Dispos. 2011 40(2)322-8

                        Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes.

                          Sanoh S, Nozaki K, Murai H, Terashita S, Teramura T, Ohta S.
                          Drug Metab Dispos. 2011 40(1)76-82

                          Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.

                            Schulz-Utermoehl T, Sarda S, Foster JR, Jacobsen M, Kenna JG, Morikawa Y, Salmu J, Gross G, Wilson ID.
                            Xenobiotica. 2012 Jun;42(6):503-17.

                            Novel cell culture-adapted genotype 2a hepatitis C virus infectious clone.

                              Date T, Kato T, Kato J, Takahashi H, Morikawa K, Akazawa D, Murayama A, Tanaka-Kaneko K, Sata T, Tanaka Y, Mizokami M, Wakita T.
                              J Virol. 2012 Oct;86(19):10805-20.

                              Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes.

                                Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Uramaru N, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
                                Drug Metab Dispos. 2012 Dec;40(12):2267-72.

                                Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

                                  Masakazu Kakuni, Mayu Morita, Kentaro Matsuo, Yumiko Katoh, Miki Nakajima,Chise Tateno, Tsuyoshi Yokoi
                                  Toxicology Letters 214 (2012) 9-18

                                  Differential Effect of Troglitazone on the Human Bile Acid Transporters, MRP2 and BSEP, in the PXB Hepatic Chimeric Mouse

                                    Foster JR, Jacobsen M, Kenna G, Schulz-Utermoehl T, Morikawa Y, Salmu J, Wilson ID.
                                    Toxicologic Pathology, 2012 Dec;40(8):1106-16.

                                    Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

                                      Samuelsson K, Pickup K, Sarda S, Swales JG, Morikawa Y, Schulz-Utermoehl T, Hutchison M, Wilson ID.
                                      Xenobiotica. 2012 Nov;42(11):1128-37.

                                      Mice with liver composed of human hepatocytes as an animal model for drug testing.

                                        Yoshizato K, Tateno C, Utoh R.

                                        Curr Drug Discov Technol. 2012 Mar;9(1):63-76. Review.

                                        Chimeric mice with humanized liver: mechanism of hepatic hyperplasia induction.

                                        Tateno C.

                                        生化学 2012 Aug;84(8):699-706.