株式会社フェニックスバイオ

Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver

Seigo Sanoh*,a, Yuka Tamuraa, Chieri Fujinoa, Go Sugaharab, Yasumi Yoshizaneb, Ami Yanagib, Keishi Kisohb, Yuji Ishidab,c, Chise Tatenob,c, Shigeru Ohtaa,d, and Yaichiro Kotakea.

BPB Reports

Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

Kang, J. A. Kim, S. Park, M. Park, H. J. Kim, J. H. Park, S. Hwang, J. R. Kim, Y. C. Jun Kim, Y. Cho, Y. Sun Jin, M. Park, S. G.

Nat Commun. 2019 May 16;10(1):2184. doi: 10.1038/s41467-019-10200-5.

READ MORE(PUB MED)

Changes in Bile Acid Concentrations in Chimeric Mice Transplanted with Different Replacement Indexes of Human Hepatocytes

Chieri Fujino,a Seigo Sanoh,*,a Yuka Tamura,a Yuji Ishida,b,c Chise Tateno,b,c Shigeru Ohta,a,d and Yaichiro Kotakea.

BPB Reports 2, 29-34 (2019)

READ MORE(PUB MED)

Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of HCV-infected Cells and Liver to Identify Pathways Associated With Disease Development

Lupberger, J. Croonenborghs, T. Roca Suarez, A. A. Van Renne, N. Juhling, F. Oudot, M. A. Virzi, A. Bandiera, S. Jamey, C. Meszaros, G. Brumaru, D. Mukherji, A. Durand, S. C. Heydmann, L. Verrier, E. R. El Saghire, H. Hamdane, N. Bartenschlager, R. Fereshetian, S. Ramberger, E. Sinha, R. Nabian, M. Everaert, C. Jovanovic, M. Mertins, P. Carr, S. A. Chayama, K. Dali-Youcef, N. Ricci, R. Bardeesy, N. M. Fujiwara, N. Gevaert, O. Zeisel, M. B. Hoshida, Y. Pochet, N. Baumert, T. F.

Gastroenterology. 2019 Apr 9. pii: S0016-5085(19)35670-7. doi: 10.1053/j.gastro.2019.04.003.

READ MORE(PUB MED)

Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver

Nakayama, K. Ito, S. Suzuki, M. Takubo, H. Yamazaki, H. Nomura, Y.

Xenobiotica. 2019 Apr; 49(4):404-414. doi:10.1080/00498254.2018.1460516. Epub 2018 Apr 19.

READ MORE(PUB MED)

HCV-induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Hamdane, N. Juhling, F. Crouchet, E. El Saghire, H. Thumann, C. Oudot, M. A. Bandiera, S. Saviano, A. Ponsolles, C. Roca Suarez, A. A. Li, S. Fujiwara, N. Ono, A. Davidson, I. Bardeesy, N. Schmidl, C. Bock, C. Schuster, C. Lupberger, J. Habersetzer, F. Doffoel, M. Piardi, T. Sommacale, D. mamura, M. Uchida, T. Ohdan, H. Aikata, H. Chayama, K. Boldanova, T. Pessaux, P. Fuchs, B. C. Hoshida, Y. Zeisel, M. B. Duong, F. H. T. Baumert, T. F.

Gastroenterology. 2019 Mar 2. pii: S0016-5085(19)32506-5. doi: 10.1053/j.gastro.2019.02.038.

READ MORE(PUB MED)

An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People

Hayashi, S. Khan, A. Simons, B. C. Homan, C. Matsui, T. Ogawa, K. Kawashima, K. Murakami, S. Takahashi, S. Isogawa, M. Ikeo, K. Mizokami, M. McMahon, B. J. Tanaka, Y.

Hepatology. 2019 Jan;69(1):19-33. doi: 10.1002/hep.30111. Epub 2018 Dec 10.

READ MORE(PUB MED)

Hepatic IFN-Induced Protein with Tetratricopeptide Repeats Regulation of HCV Infection

Ishida, Y. Kakuni, M. Bang, B. R. Sugahara, G. Lau, D. T. Tateno-Mukaidani, C. Li, M. Gale, M., Jr. Saito, T.

J Interferon Cytokine Res. 2019 Mar;39(3):133-146. doi: 10.1089/jir.2018.0103.

READ MORE(PUB MED)

Early Multiphasic HBV Infection Initiation Kinetics Is Not Clone-Specific and Is Not Affected by Hepatitis D Virus (HDV) Infection

Tsuge, M. Uchida, T. Walsh, K. Ishida, Y. Tateno, C. Kumar, U. Glenn, J. S. Koh, C. Heller, T. Uprichard, S. L. Dahari, H. Chayama, K.

Viruses. 2019 Mar 15;11(3). pii: v11030263. doi: 10.3390/v11030263.

READ MORE(PUB MED)

Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation

Kitab, B. Satoh, M. Ohmori, Y. Munakata, T. Sudoh, M. Kohara, M. Tsukiyama-Kohara, K.

J Biol Chem. 2019 Feb 12. pii: RA118.004397. doi: 10.1074/jbc.RA118.004397.

READ MORE(PUB MED)

Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

Miyamoto, M. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Kosugi, Y. Hirabayashi, H.

Xenobiotica. 2019 Feb 12:1-31. doi: 10.1080/00498254.2019.1579394.

READ MORE(PUB MED)

Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice

Tsushima, K. Tsuge, M. Hiraga, N. Uchida, T. Murakami, E. Makokha, G. N. Kurihara, M. Nomura, M. Hiyama, Y. Fujino, H. Ono, A. Nakahara, T. Yamauchi, M. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Chayama, K.

J Gastroenterol. 2019 Feb 21. pii: 10.1007/s00535-019-01558-w. doi: 10.1007/s00535-019-01558-w.

READ MORE(PUB MED)

MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct

Jain, R. Frederick, J. P. Huang, E. Y. Burke, K. E. Mauger, D. M. Andrianova, E. A. Farlow, S. J.Siddiqui, S. Pimentel, J. Cheung-Ong, K. McKinney, K. M. Kohrer, C. Moore, M. J. Chakraborty, T.

Nucleic Acid Ther. 2018 Oct;28(5):285-296.

READ MORE(PUB MED)

Chimeric mice with human hepatocytes: A new system for genotoxicity studies

C. Tateno, M. Fukumuro, S. Masumori, M. Kakuni, Y. Ishida, T. Shimada, M. Hayashi

Mutat Res. 2019 Mar;839:9-12

READ MORE(PUB MED)

Functional Analysis of Human Hepatocytes Isolated From Chimeric Mouse Liver

Harimoto, N. Nakagawara, H. Shirabe, K. Yoshizumi, T. Itoh, S. Ikegami, T. Soejima, Y. Maehara, Y. Ishida, Y. Tateno, C. Tanaka, Y.

Transplant Proc. 2018 Dec;50(10):3858-3862. doi: 10.1016/j.transproceed.2018.06.035.

READ MORE(PUB MED)

Lack of human relevance for procymidone’s developmental toxicity attributable to species difference in its kinetics and metabolism

Tomigahara, Y. Tarui, H. Matsui, M. Kurosawa, M. Kawamura, S. Isobe, N.

J Pestic Sci. 2018 May 20;43(2):114-123. doi: 10.1584/jpestics.D17-085.

READ MORE(PUB MED)

Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model

Ye, X. Tateno, C. Thi, E. P. Kakuni, M. Snead, N. M. Ishida, Y. Barnard, T. R. Sofia, M. Shimada, T. Lee, A. C. H.

ACS Infect Dis. 2018 Nov 8. doi: 10.1021/acsinfecdis.8b00192.

READ MORE(PUB MED)

ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection

Thi, E. P. Dhillon, A. P. Ardzinski, A. Bidirici-Ertekin, L. Cobarrubias, K. D. Cuconati, A. Kondratowicz, A. S. Kwak, K. Li, A. H. L. Miller, A. Pasetka, C. Pei, L.Phelps, J. R. Snead, N. M. Wang, X. Ye, X. Sofia, M. J. Lee, A. C. H.

ACS Infect Dis. 2018 Nov 19. doi: 10.1021/acsinfecdis.8b00191.

READ MORE(PUB MED)

Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes

Tsuge, M. Hiraga, N. Zhang, Y. Yamashita, M. Sato, O. Oka, N. Shiraishi, K. Izaki, Y. Makokha, G. N. Uchida, T. Kurihara, M. Nomura, M. Tsushima, K. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Hayes, C. N. Fujita, T. Chayama, K.

Virology. 2018 Sep 18;525:48-61. doi: 10.1016/j.virol.2018.08.020.

READ MORE(PUB MED)

CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients

Nomura, M. Tsuge, M. Uchida, T. Hiraga, N. Kurihara, M. Tsushima, K. Fujino, H. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Hiramatsu, A. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Zhang, Y. Makokha, G. N. Hayes, C. N. Tanaka, S. Chayama, K.

J Viral Hepat. 2018 Jul 11. doi: 10.1111/jvh.12970.

READ MORE(PUB MED)

研究発表

Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver

Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

Changes in Bile Acid Concentrations in Chimeric Mice Transplanted with Different Replacement Indexes of Human Hepatocytes

Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of HCV-infected Cells and Liver to Identify Pathways Associated With Disease Development

Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver

HCV-induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People

Hepatic IFN-Induced Protein with Tetratricopeptide Repeats Regulation of HCV Infection

Early Multiphasic HBV Infection Initiation Kinetics Is Not Clone-Specific and Is Not Affected by Hepatitis D Virus (HDV) Infection

Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation

Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice

MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct

Chimeric mice with human hepatocytes: A new system for genotoxicity studies

Functional Analysis of Human Hepatocytes Isolated From Chimeric Mouse Liver

Lack of human relevance for procymidone’s developmental toxicity attributable to species difference in its kinetics and metabolism

Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model

ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection

Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes

CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients