Phoenix Bio

研究発表

研究発表

Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

    Takehara, I. Watanabe, N. Mori, D. Ando, O. Kusuhara, H.

    J Pharm Sci. 2019 Mar 21.

    Anti-HBV activity of retinoid drugs in vitro versus in vivo

      Birkus, G. Snyder, C. Jordan, R. Kobayashi, T. Dick, R. Puscau, V. Li, L. Ramirez, R. Willkom, M. Morikawa, Y. Delaney, W. Schmitz, U.

      Antiviral Res. 2019 Jun 18:104538. doi: 10.1016/j.antiviral.2019.104538.

      2019/07/25

      第29回抗ウイルス療法学会学術集会でのPXBマウス及びPXB-cells関連研究発表のご案内

      2019年7月18日(木)~7月20日(土)に開催されました 第29回抗ウイルス療法学会学術集会にて、PXBマウス及びPXB-cells関連の研究発表がありましたのでご案内を致します。

      Humanized Mouse Models for the Study of Hepatitis C and Host Interactions

        Yong, K. S. M. Her, Z. Chen, Q.

        Cells. 2019 Jun 17;8(6). pii: cells8060604.

        Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with in Vitro-in Vivo Extrapolation and Allometric Scaling

          Naritomi, Y. Sanoh, S. Ohta, S.

          Biol Pharm Bull. 2019;42(3):327-336. doi: 10.1248/bpb.b18-00754.

          Mice with Chimeric Human Livers and Their Applications

            Douglas, D. N. Kneteman, N. M.

            Methods Mol Biol. 2019;1911:459-479.

            Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver

            Seigo Sanoh*,a, Yuka Tamuraa, Chieri Fujinoa, Go Sugaharab, Yasumi Yoshizaneb, Ami Yanagib, Keishi Kisohb, Yuji Ishidab,c, Chise Tatenob,c, Shigeru Ohtaa,d, and Yaichiro Kotakea.

            BPB Reports

            Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

              Kang, J. A. Kim, S. Park, M. Park, H. J. Kim, J. H. Park, S. Hwang, J. R. Kim, Y. C. Jun Kim, Y. Cho, Y. Sun Jin, M. Park, S. G.

              Nat Commun. 2019 May 16;10(1):2184. doi: 10.1038/s41467-019-10200-5.

              Changes in Bile Acid Concentrations in Chimeric Mice Transplanted with Different Replacement Indexes of Human Hepatocytes

                Chieri Fujino,a Seigo Sanoh,*,a Yuka Tamura,a Yuji Ishida,b,c Chise Tateno,b,c Shigeru Ohta,a,d and Yaichiro Kotakea.

                BPB Reports 2, 29-34 (2019)

                Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of HCV-infected Cells and Liver to Identify Pathways Associated With Disease Development

                  Lupberger, J. Croonenborghs, T. Roca Suarez, A. A. Van Renne, N. Juhling, F. Oudot, M. A. Virzi, A. Bandiera, S. Jamey, C. Meszaros, G. Brumaru, D. Mukherji, A. Durand, S. C. Heydmann, L. Verrier, E. R. El Saghire, H. Hamdane, N. Bartenschlager, R. Fereshetian, S. Ramberger, E. Sinha, R. Nabian, M. Everaert, C. Jovanovic, M. Mertins, P. Carr, S. A. Chayama, K. Dali-Youcef, N. Ricci, R. Bardeesy, N. M. Fujiwara, N. Gevaert, O. Zeisel, M. B. Hoshida, Y. Pochet, N. Baumert, T. F.

                  Gastroenterology. 2019 Apr 9. pii: S0016-5085(19)35670-7. doi: 10.1053/j.gastro.2019.04.003.

                  Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver

                    Nakayama, K. Ito, S. Suzuki, M. Takubo, H. Yamazaki, H. Nomura, Y.

                    Xenobiotica. 2019 Apr; 49(4):404-414.  doi:10.1080/00498254.2018.1460516. Epub 2018 Apr 19.

                    HCV-induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

                      Hamdane, N. Juhling, F. Crouchet, E. El Saghire, H. Thumann, C. Oudot, M. A. Bandiera, S. Saviano, A. Ponsolles, C. Roca Suarez, A. A. Li, S. Fujiwara, N. Ono, A. Davidson, I. Bardeesy, N. Schmidl, C. Bock, C. Schuster, C. Lupberger, J. Habersetzer, F. Doffoel, M. Piardi, T. Sommacale, D. mamura, M. Uchida, T. Ohdan, H. Aikata, H. Chayama, K. Boldanova, T. Pessaux, P. Fuchs, B. C. Hoshida, Y. Zeisel, M. B. Duong, F. H. T. Baumert, T. F.

                      Gastroenterology. 2019 Mar 2. pii: S0016-5085(19)32506-5. doi: 10.1053/j.gastro.2019.02.038.

                      An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People

                        Hayashi, S. Khan, A. Simons, B. C. Homan, C. Matsui, T. Ogawa, K. Kawashima, K. Murakami, S. Takahashi, S. Isogawa, M. Ikeo, K. Mizokami, M. McMahon, B. J. Tanaka, Y.

                        Hepatology. 2019 Jan;69(1):19-33. doi: 10.1002/hep.30111. Epub 2018 Dec 10.

                        Hepatic IFN-Induced Protein with Tetratricopeptide Repeats Regulation of HCV Infection

                          Ishida, Y. Kakuni, M. Bang, B. R. Sugahara, G. Lau, D. T. Tateno-Mukaidani, C. Li, M. Gale, M., Jr. Saito, T.

                          J Interferon Cytokine Res. 2019 Mar;39(3):133-146. doi: 10.1089/jir.2018.0103.

                          Early Multiphasic HBV Infection Initiation Kinetics Is Not Clone-Specific and Is Not Affected by Hepatitis D Virus (HDV) Infection

                            Tsuge, M. Uchida, T. Walsh, K. Ishida, Y. Tateno, C. Kumar, U. Glenn, J. S. Koh, C. Heller, T. Uprichard, S. L. Dahari, H. Chayama, K.

                            Viruses. 2019 Mar 15;11(3). pii: v11030263. doi: 10.3390/v11030263.

                            Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation

                              Kitab, B. Satoh, M. Ohmori, Y. Munakata, T. Sudoh, M. Kohara, M. Tsukiyama-Kohara, K.

                              J Biol Chem. 2019 Feb 12. pii: RA118.004397. doi: 10.1074/jbc.RA118.004397.

                              Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

                                Miyamoto, M. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Kosugi, Y. Hirabayashi, H.

                                Xenobiotica. 2019 Feb 12:1-31. doi: 10.1080/00498254.2019.1579394.

                                Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice

                                  Tsushima, K. Tsuge, M. Hiraga, N. Uchida, T. Murakami, E. Makokha, G. N. Kurihara, M. Nomura, M. Hiyama, Y. Fujino, H. Ono, A. Nakahara, T. Yamauchi, M. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Chayama, K.

                                  J Gastroenterol. 2019 Feb 21. pii: 10.1007/s00535-019-01558-w. doi: 10.1007/s00535-019-01558-w.

                                  MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct

                                    Jain, R. Frederick, J. P. Huang, E. Y. Burke, K. E. Mauger, D. M. Andrianova, E. A. Farlow, S. J.Siddiqui, S. Pimentel, J. Cheung-Ong, K. McKinney, K. M. Kohrer, C. Moore, M. J. Chakraborty, T.

                                    Nucleic Acid Ther. 2018 Oct;28(5):285-296.

                                    Chimeric mice with human hepatocytes: A new system for genotoxicity studies

                                      C. Tateno, M. Fukumuro, S. Masumori, M. Kakuni, Y. Ishida, T. Shimada, M. Hayashi

                                      Mutat Res. 2019 Mar;839:9-12