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An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People

Hayashi, S. Khan, A. Simons, B. C. Homan, C. Matsui, T. Ogawa, K. Kawashima, K. Murakami, S. Takahashi, S. Isogawa, M. Ikeo, K. Mizokami, M. McMahon, B. J. Tanaka, Y.

Hepatology. 2019 Jan;69(1):19-33. doi: 10.1002/hep.30111. Epub 2018 Dec 10.

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Hepatic IFN-Induced Protein with Tetratricopeptide Repeats Regulation of HCV Infection

Ishida, Y. Kakuni, M. Bang, B. R. Sugahara, G. Lau, D. T. Tateno-Mukaidani, C. Li, M. Gale, M., Jr. Saito, T.

J Interferon Cytokine Res. 2019 Mar;39(3):133-146. doi: 10.1089/jir.2018.0103.

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Early Multiphasic HBV Infection Initiation Kinetics Is Not Clone-Specific and Is Not Affected by Hepatitis D Virus (HDV) Infection

Tsuge, M. Uchida, T. Walsh, K. Ishida, Y. Tateno, C. Kumar, U. Glenn, J. S. Koh, C. Heller, T. Uprichard, S. L. Dahari, H. Chayama, K.

Viruses. 2019 Mar 15;11(3). pii: v11030263. doi: 10.3390/v11030263.

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Prediction of Human Hepatic Clearance for Cytochrome P450 Substrates via a New Culture Method Using the Collagen Vitrigel Membrane Chamber and Fresh Hepatocytes Isolated from Liver Humanized Mice

Watari, R. Kakiki, M. Yamasaki, C. Ishida, Y. Tateno, C. Kuroda, Y. Ishida, S. Kusano, K.

Biol Pharm Bull. 2019;42(3):348-353. doi: 10.1248/bpb.b18-00582.

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Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation

Kitab, B. Satoh, M. Ohmori, Y. Munakata, T. Sudoh, M. Kohara, M. Tsukiyama-Kohara, K.

J Biol Chem. 2019 Feb 12. pii: RA118.004397. doi: 10.1074/jbc.RA118.004397.

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Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

Miyamoto, M. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Kosugi, Y. Hirabayashi, H.

Xenobiotica. 2019 Feb 12:1-31. doi: 10.1080/00498254.2019.1579394.

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Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice

Tsushima, K. Tsuge, M. Hiraga, N. Uchida, T. Murakami, E. Makokha, G. N. Kurihara, M. Nomura, M. Hiyama, Y. Fujino, H. Ono, A. Nakahara, T. Yamauchi, M. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Chayama, K.

J Gastroenterol. 2019 Feb 21. pii: 10.1007/s00535-019-01558-w. doi: 10.1007/s00535-019-01558-w.

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MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct

Jain, R. Frederick, J. P. Huang, E. Y. Burke, K. E. Mauger, D. M. Andrianova, E. A. Farlow, S. J.Siddiqui, S. Pimentel, J. Cheung-Ong, K. McKinney, K. M. Kohrer, C. Moore, M. J. Chakraborty, T.

Nucleic Acid Ther. 2018 Oct;28(5):285-296.

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Chimeric mice with human hepatocytes: A new system for genotoxicity studies

C. Tateno, M. Fukumuro, S. Masumori, M. Kakuni, Y. Ishida, T. Shimada, M. Hayashi

Mutat Res. 2019 Mar;839:9-12

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Functional Analysis of Human Hepatocytes Isolated From Chimeric Mouse Liver

Harimoto, N. Nakagawara, H. Shirabe, K. Yoshizumi, T. Itoh, S. Ikegami, T. Soejima, Y. Maehara, Y. Ishida, Y. Tateno, C. Tanaka, Y.

Transplant Proc. 2018 Dec;50(10):3858-3862. doi: 10.1016/j.transproceed.2018.06.035.

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Lack of human relevance for procymidone’s developmental toxicity attributable to species difference in its kinetics and metabolism

Tomigahara, Y. Tarui, H. Matsui, M. Kurosawa, M. Kawamura, S. Isobe, N.

J Pestic Sci. 2018 May 20;43(2):114-123. doi: 10.1584/jpestics.D17-085.

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Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model

Ye, X. Tateno, C. Thi, E. P. Kakuni, M. Snead, N. M. Ishida, Y. Barnard, T. R. Sofia, M. Shimada, T. Lee, A. C. H.

ACS Infect Dis. 2018 Nov 8. doi: 10.1021/acsinfecdis.8b00192.

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ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection

Thi, E. P. Dhillon, A. P. Ardzinski, A. Bidirici-Ertekin, L. Cobarrubias, K. D. Cuconati, A. Kondratowicz, A. S. Kwak, K. Li, A. H. L. Miller, A. Pasetka, C. Pei, L.Phelps, J. R. Snead, N. M. Wang, X. Ye, X. Sofia, M. J. Lee, A. C. H.

ACS Infect Dis. 2018 Nov 19. doi: 10.1021/acsinfecdis.8b00191.

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Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes

Tsuge, M. Hiraga, N. Zhang, Y. Yamashita, M. Sato, O. Oka, N. Shiraishi, K. Izaki, Y. Makokha, G. N. Uchida, T. Kurihara, M. Nomura, M. Tsushima, K. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Hayes, C. N. Fujita, T. Chayama, K.

Virology. 2018 Sep 18;525:48-61. doi: 10.1016/j.virol.2018.08.020.

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Chimeric mice with humanized livers demonstrate human-specific hepatotoxicity caused by a therapeutic antibody against TRAIL-receptor 2/death receptor 5

Nihira, K. Nan-Ya, K. I. Kakuni, M. Ono, Y. Yoshikawa, Y. Ota, T. Hiura, M. Yoshinari, K.

Toxicol Sci. 2018 Sep 9. pii: 5093319. doi: 10.1093/toxsci/kfy228.

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CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients

Nomura, M. Tsuge, M. Uchida, T. Hiraga, N. Kurihara, M. Tsushima, K. Fujino, H. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Hiramatsu, A. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Zhang, Y. Makokha, G. N. Hayes, C. N. Tanaka, S. Chayama, K.

J Viral Hepat. 2018 Jul 11. doi: 10.1111/jvh.12970.

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The metabolic fate of fenclozic acid in chimeric mice with a humanized liver

Ekdahl, A. Weidolf, L. Baginski, M. Morikawa, Y. Thompson, R. A. Wilson, I. D.

Arch Toxicol. 2018 Sep;92(9):2819-2828.

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Inhibitory effect of fasiglifam on hepatitis B virus infections through suppression of the sodium taurocholate cotransporting polypeptide

Nio, Y. Akahori, Y. Okamura, H. Watashi, K. Wakita, T. Hijikata, M.

Biochem Biophys Res Commun. 2018 Jun 27;501(3):820-825.

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Inhibitory effect of silibinin on hepatitis B virus entry

Umetsu, T. Inoue, J. Kogure, T. Kakazu, E. Ninomiya, M. Iwata, T. Takai, S. Nakamura, T.Sano, A. Shimosegawa, T.

Biochem Biophys Rep. 2018 Mar 31;14:20-25.

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A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers

Watari, R. Kakiki, M. Oshikata, A. Takezawa, T. Yamasaki, C. Ishida, Y. Tateno, C. Kuroda, Y. Ishida, S. Kusano, K.

J Toxicol Sci. 2018;43(8):521-529.

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