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論文一覧

ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection

Thi, E. P. Dhillon, A. P. Ardzinski, A. Bidirici-Ertekin, L. Cobarrubias, K. D. Cuconati, A. Kondratowicz, A. S. Kwak, K. Li, A. H. L. Miller, A. Pasetka, C. Pei, L.Phelps, J. R. Snead, N. M. Wang, X. Ye, X. Sofia, M. J. Lee, A. C. H.

ACS Infect Dis. 2018 Nov 19. doi: 10.1021/acsinfecdis.8b00191.

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Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes

Tsuge, M. Hiraga, N. Zhang, Y. Yamashita, M. Sato, O. Oka, N. Shiraishi, K. Izaki, Y. Makokha, G. N. Uchida, T. Kurihara, M. Nomura, M. Tsushima, K. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Hayes, C. N. Fujita, T. Chayama, K.

Virology. 2018 Sep 18;525:48-61. doi: 10.1016/j.virol.2018.08.020.

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Chimeric mice with humanized livers demonstrate human-specific hepatotoxicity caused by a therapeutic antibody against TRAIL-receptor 2/death receptor 5

Nihira, K. Nan-Ya, K. I. Kakuni, M. Ono, Y. Yoshikawa, Y. Ota, T. Hiura, M. Yoshinari, K.

Toxicol Sci. 2018 Sep 9. pii: 5093319. doi: 10.1093/toxsci/kfy228.

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CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients

Nomura, M. Tsuge, M. Uchida, T. Hiraga, N. Kurihara, M. Tsushima, K. Fujino, H. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Hiramatsu, A. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Zhang, Y. Makokha, G. N. Hayes, C. N. Tanaka, S. Chayama, K.

J Viral Hepat. 2018 Jul 11. doi: 10.1111/jvh.12970.

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The metabolic fate of fenclozic acid in chimeric mice with a humanized liver

Ekdahl, A. Weidolf, L. Baginski, M. Morikawa, Y. Thompson, R. A. Wilson, I. D.

Arch Toxicol. 2018 Sep;92(9):2819-2828.

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Inhibitory effect of fasiglifam on hepatitis B virus infections through suppression of the sodium taurocholate cotransporting polypeptide

Nio, Y. Akahori, Y. Okamura, H. Watashi, K. Wakita, T. Hijikata, M.

Biochem Biophys Res Commun. 2018 Jun 27;501(3):820-825.

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Inhibitory effect of silibinin on hepatitis B virus entry

Umetsu, T. Inoue, J. Kogure, T. Kakazu, E. Ninomiya, M. Iwata, T. Takai, S. Nakamura, T.Sano, A. Shimosegawa, T.

Biochem Biophys Rep. 2018 Mar 31;14:20-25.

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A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers

Watari, R. Kakiki, M. Oshikata, A. Takezawa, T. Yamasaki, C. Ishida, Y. Tateno, C. Kuroda, Y. Ishida, S. Kusano, K.

J Toxicol Sci. 2018;43(8):521-529.

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Inhibitory effect of Japanese rice-koji miso extracts on hepatitis A virus replication in association with the elevation of glucose-regulated protein 78 expression

Win, N. N. Kanda, T. Nakamoto, S. Moriyama, M. Jiang, X. Suganami, A. Tamura, Y. Okamoto, H. Shirasawa, H.

Int J Med Sci. 2018 Jul 30;15(11):1153-1159.

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新規ready-to-use ヒト肝細胞三次元培養システム「PXB-able」の有用性の検討

赤平有希、山崎ちひろ、石田雄二、立野知世、城村友子

BIO-INDUSTRY 2018;35（3）：27-37

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Contribution of chimeric mice with a humanized liver to the evaluation of pharmacology, toxicity, and pharmacokinetics in drug discovery and development

Sanoh, S. Ohta, S.

Nihon Yakurigaku Zasshi. 2018;151(5):213-220

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Use of hepatocytes isolated from a liver-humanized mouse for studies on the metabolism of drugs: application to the metabolism of fentanyl and acetylfentanyl

Kanamori, T. Togawa-Iwata, Y. Segawa, H. Yamamuro, T. Kuwayama, K. Tsujikawa, K. Inoue, H.

Forensic Toxicol. 2018;36(2):467-475.

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Limitations of daclatasvir/asunaprevir plus beclabuvir treatment in cases of NS5A inhibitor treatment failure

Teraoka, Y. Uchida, T. Imamura, M. Hiraga, N. Osawa, M. Kan, H. Saito, Y. Tsuge, M. Abe-Chayama, H. Hayes, C. N. Makokha, G. N. Aikata, H. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

J Gen Virol. 2018 Jun 19. doi: 10.1099/jgv.0.001091.

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Generation of the Adenovirus Vector-Mediated CRISPR/Cpf1 System and the Application for Primary Human Hepatocytes Prepared from Humanized Mice with Chimeric Liver

Tsukamoto, T. Sakai, E. Iizuka, S. Taracena-Gandara, M. Sakurai, F. Mizuguchi, H.

Biol Pharm Bull. 2018;41(7):1089-1095. doi: 10.1248/bpb.b18-00222.

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Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers

Furuta, M. Tanaka, H. Shiraishi, Y. Unida, T. mamura, M. Fujimoto, A. Fujita, M. Sasaki-Oku, A. Maejima, K. Nakano, K. Kawakami, Y. Arihiro, K. Aikata, H. Ueno, M. Hayami, S. Ariizumi, S. I. Yamamoto, M. Gotoh, K. Ohdan, H. Yamaue, H. Miyano, S. Chayama, K. Nakagawa, H.

Oncotarget. 2018 May 18;9(38):25075-25088.

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The whole transcriptome effects of the PPARalpha agonist fenofibrate on livers of hepatocyte humanized mice

de la Rosa Rodriguez, M. A. Sugahara, G. Hooiveld, Gjej Ishida, Y. Tateno, C. Kersten, S.

BMC Genomics. 2018 Jun 7;19(1):443. doi: 10.1186/s12864-018-4834-3.

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Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction

Tsukamoto, Y. Ikeda, S. Uwai, K. Taguchi, R. Chayama, K. Sakaguchi, T. Narita, R. Yao, W. L. Takeuchi, F. Otakaki, Y. Watashi, K. Wakita, T. Kato, H. Fujita, T.

PLoS One. 2018 May 21;13(5):e0197664.

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Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery

Naritomi, Y. Sanoh, S. Ohta, S.

Drug Metab Pharmacokinet. 2017 Nov 9. pii: S1347-4367(17)30150-7. doi: 10.1016/j.dmpk.2017.11.001.

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Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6

Livingston, C. M. Ramakrishnan, D. Strubin, M. Fletcher, S. P. Beran, R. K.

Viruses. 2017 Apr 3;9(4). pii: E69. doi: 10.3390/v9040069.

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Propagation of Human Hepatocytes in uPA/SCID Mice: Producing Chimeric Mice with Humanized Liver

Ohshita, H. Tateno, C.

Methods Mol Biol. 2017;1506:91-100. (Book of Hepatocyte Transplantation)

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