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Comparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mice (hCAR/hPXR mice)

Yamada, T. Ohara, A. Ozawa, N. Maeda, K. Kondo, M. Okuda, Y. Abe, J. Cohen, S. M. Lake, B. G.

Toxicol Sci. 2020 Jul 31. pii: 5879297. doi: 10.1093/toxsci/kfaa125.

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Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse

Miyamoto, M. Kosugi, Y. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Hirabayashi, H.

Xenobiotica. 2020 Aug 25:1-10. doi: 10.1080/00498254.2020.1808735

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Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver

Kato, S. Shah, A. Plesescu, M. Miyata, Y. Bolleddula, J. Chowdhury, S. Zhu, X.

Drug Metab Dispos. 2020 Jul 14. pii: dmd.120.000128. doi: 10.1124/dmd.120.000128.

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Signal activation of hepatitis B virus-related hepatocarcinogenesis by upregulation of SUV39h1

Takeuchi, Y. Tsuge, M. Tsushima, K. Suehiro, Y. Fujino, H. Ono, A. Yamauchi, M. Makokha, G. N. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Tateno, C.　Chayama, K.

J Infect Dis. 2020 Jun 9:jiaa317. doi: 10.1093/infdis/jiaa317.

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Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

Steeneck, C. Kinzel, O. Anderhub, S. Hornberger, M. Pinto, S. Morschhaeuser, B. Braun, F. Kleymann, G. Hoffmann, T.

ACS Med Chem Lett. 2020 Jan 27;11(2):179-187. doi: 10.1021/acsmedchemlett.9b00572. eCollection 2020 Feb 13.

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Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: Integration with hepatic drug metabolism

Sanoh, S. Naritomi, Y. Kitamura, S. Shinagawa, A. Kakuni, M. Tateno, C. Ohta, S.

Xenobiotica. 2020 Jun 5:1-10. doi: 10.1080/00498254.2020.1769229.

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A novel evaluation method for determining drug-induced hepatotoxicity using 3D bio-printed human liver tissue

Ide, I. Nagao, E. Kajiyama, S. Mizoguchi, N.

Toxicol Mech Methods. 2020 Mar;30(3):189-196. doi: 10.1080/15376516.2019.1686795. Epub 2019 Nov 21.

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Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus

Matsunaga, S. Jeremiah, S. S. Miyakawa, K. Kurotaki, D. Shizukuishi, S. Watashi, K. Nishitsuji, H. Kimura, H. Tamura, T. Yamamoto, N. Shimotohno, K. Wakita, T. Ryo, A.

iScience. 2020 Mar 27;23(3):100867. doi: 10.1016/j.isci.2020.100867. Epub 2020 Feb 26.

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Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir

Wang, T. Babusis, D. Park, Y. Niu, C. Kim, C. Zhao, X. Lu, B. Ma, B. Muench, R. C. Sperger, D. Ray, A. S. Murakami, E.

Drug Metab Pharmacokinet. 2020 Jun;35(3):334-340. doi: 10.1016/j.dmpk.2020.04.333. Epub 2020 Apr 16.

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Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

Sugahara, G. Ishida, Y. Sun, J. Tateno, C. Saito, T.

Semin Liver Dis. 2020 Feb 19. doi: 10.1055/s-0040-1701444.

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Characterization and applications of chimeric mice with humanized livers for preclinical drug development

Tateno, Chise; Kojima, Yuha

Laboratory Animal Research volume 36, Article number: 2 (2020)

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Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

Cheng, X. Uchida, T. Xia, Y. Umarova, R. Liu, C. J. Chen, P. J. Gaggar, A. Suri, V. Mucke, M. M. Vermehren, J. Zeuzem, S. Teraoka, Y. Osawa, M. Aikata, H. Tsuji, K. Mori, N. Hige, S. Karino, Y. Imamura, M. Chayama, K. Liang, T. J.

J Clin Invest. 2020 Mar 12. pii: 135616. doi: 10.1172/JCI135616.

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Lipoprotein profile and lipid metabolism of PXB-cells((R)), human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs

Hata, K. Sayaka, T. Takahashi, M. Sasaki, A. Umekawa, Y. Miyashita, K. Ogura, K. Toshima, G. Maeda, M. Takahashi, J. Kakuni, M.

Biomed Res. 2020;41(1):33-42. doi: 10.2220/biomedres.41.33.

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Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver

Ikeyama, Y. Sato, T. Takemura, A. Sekine, S. Ito, K.

Toxicol In Vitro. 2020 Jan 25:104785. doi: 10.1016/j.tiv.2020.104785.

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High-throughput screening to evaluate inhibition of bile acid transporters using human hepatocytes isolated from chimeric mice

Kohara, H. Bajaj, P. Yamanaka, K. Miyawaki, A. Harada, K. Miyamoto, K. Matsui, T. Okai, Y. Wagoner, M. Shinozawa, T.

Toxicol Sci. 2019 Nov 13. pii: 5625164. doi: 10.1093/toxsci/kfz229.

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Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-treated Liver-Humanized PXB Mice

King, A. Baginski, M. Morikawa, Y. Rainville, P. D. Gethings, L. A. Wilson, I. D. Plumb, R. S.

J Proteome Res. 2019 Oct 8. doi: 10.1021/acs.jproteome.9b00334..

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Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

Katsuda, T. Matsuzaki, J. Yamaguchi, T. Yamada, Y. Prieto-Vila, M. Hosaka, K. Takeuchi, A. Saito, Y. Ochiya, T.

Elife. 2019 Aug 8;8. pii: 47313. doi: 10.7554/eLife.47313.

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Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice

Osawa, M. Uchida, T. Imamura, M. Teraoka, Y. Fujino, H. Nakahara, T. Ono, A. Murakami, E. Kawaoka, T. Miki, D. Tsuge, M. Hiramatsu, A. Abe-Chayama, H. Hayes, C. N.

J Gen Virol. 2019 Jul;100(7):1123-1131.

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Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

Takehara, I. Watanabe, N. Mori, D. Ando, O. Kusuhara, H.

J Pharm Sci. 2019 Mar 21.

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Anti-HBV activity of retinoid drugs in vitro versus in vivo

Birkus, G. Snyder, C. Jordan, R. Kobayashi, T. Dick, R. Puscau, V. Li, L. Ramirez, R. Willkom, M. Morikawa, Y. Delaney, W. Schmitz, U.

Antiviral Res. 2019 Jun 18:104538. doi: 10.1016/j.antiviral.2019.104538.

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