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論文一覧

論文一覧

論文一覧

High-throughput screening to evaluate inhibition of bile acid transporters using human hepatocytes isolated from chimeric mice

    Kohara, H. Bajaj, P. Yamanaka, K. Miyawaki, A. Harada, K. Miyamoto, K. Matsui, T. Okai, Y. Wagoner, M. Shinozawa, T.

    Toxicol Sci. 2019 Nov 13. pii: 5625164. doi: 10.1093/toxsci/kfz229.

    Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-treated Liver-Humanized PXB Mice

      King, A. Baginski, M. Morikawa, Y. Rainville, P. D. Gethings, L. A. Wilson, I. D. Plumb, R. S.

      J Proteome Res. 2019 Oct 8. doi: 10.1021/acs.jproteome.9b00334..

      Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

        Katsuda, T. Matsuzaki, J. Yamaguchi, T. Yamada, Y. Prieto-Vila, M. Hosaka, K. Takeuchi, A. Saito, Y. Ochiya, T.

        Elife. 2019 Aug 8;8. pii: 47313. doi: 10.7554/eLife.47313.

        Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice

          Osawa, M. Uchida, T. Imamura, M. Teraoka, Y. Fujino, H. Nakahara, T. Ono, A. Murakami, E. Kawaoka, T. Miki, D. Tsuge, M. Hiramatsu, A. Abe-Chayama, H. Hayes, C. N.

          J Gen Virol. 2019 Jul;100(7):1123-1131.

          Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

            Takehara, I. Watanabe, N. Mori, D. Ando, O. Kusuhara, H.

            J Pharm Sci. 2019 Mar 21.

            Anti-HBV activity of retinoid drugs in vitro versus in vivo

              Birkus, G. Snyder, C. Jordan, R. Kobayashi, T. Dick, R. Puscau, V. Li, L. Ramirez, R. Willkom, M. Morikawa, Y. Delaney, W. Schmitz, U.

              Antiviral Res. 2019 Jun 18:104538. doi: 10.1016/j.antiviral.2019.104538.

              An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes

                Furutani, Y. Toguchi, M. Shiozaki-Sato, Y. Qin, X. Y. Ebisui, E. Higuchi, S. Sudoh, M. Suzuki, H. Takahashi, N. Watashi, K. Wakita, T. Kakeya, H. Kojima, S.

                PLoS One. 2019 Jun 12;14(6):e0216139. doi: 10.1371/journal.pone.0216139. eCollection 2019.

                Humanized Mouse Models for the Study of Hepatitis C and Host Interactions

                  Yong, K. S. M. Her, Z. Chen, Q.

                  Cells. 2019 Jun 17;8(6). pii: cells8060604.

                  Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with in Vitro-in Vivo Extrapolation and Allometric Scaling

                    Naritomi, Y. Sanoh, S. Ohta, S.

                    Biol Pharm Bull. 2019;42(3):327-336. doi: 10.1248/bpb.b18-00754.

                    Mice with Chimeric Human Livers and Their Applications

                      Douglas, D. N. Kneteman, N. M.

                      Methods Mol Biol. 2019;1911:459-479.

                      Study of the Metabolism of New Drugs of Abuse

                        Kanamori, T.

                        Yakugaku Zasshi. 2019;139(5):699-704. doi: 10.1248/yakushi.18-00166-3.

                        Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver

                        Seigo Sanoh*,a, Yuka Tamuraa, Chieri Fujinoa, Go Sugaharab, Yasumi Yoshizaneb, Ami Yanagib, Keishi Kisohb, Yuji Ishidab,c, Chise Tatenob,c, Shigeru Ohtaa,d, and Yaichiro Kotakea.

                        BPB Reports

                        Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

                          Kang, J. A. Kim, S. Park, M. Park, H. J. Kim, J. H. Park, S. Hwang, J. R. Kim, Y. C. Jun Kim, Y. Cho, Y. Sun Jin, M. Park, S. G.

                          Nat Commun. 2019 May 16;10(1):2184. doi: 10.1038/s41467-019-10200-5.

                          Changes in Bile Acid Concentrations in Chimeric Mice Transplanted with Different Replacement Indexes of Human Hepatocytes

                            Chieri Fujino,a Seigo Sanoh,*,a Yuka Tamura,a Yuji Ishida,b,c Chise Tateno,b,c Shigeru Ohta,a,d and Yaichiro Kotakea.

                            BPB Reports 2, 29-34 (2019)

                            Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of HCV-infected Cells and Liver to Identify Pathways Associated With Disease Development

                              Lupberger, J. Croonenborghs, T. Roca Suarez, A. A. Van Renne, N. Juhling, F. Oudot, M. A. Virzi, A. Bandiera, S. Jamey, C. Meszaros, G. Brumaru, D. Mukherji, A. Durand, S. C. Heydmann, L. Verrier, E. R. El Saghire, H. Hamdane, N. Bartenschlager, R. Fereshetian, S. Ramberger, E. Sinha, R. Nabian, M. Everaert, C. Jovanovic, M. Mertins, P. Carr, S. A. Chayama, K. Dali-Youcef, N. Ricci, R. Bardeesy, N. M. Fujiwara, N. Gevaert, O. Zeisel, M. B. Hoshida, Y. Pochet, N. Baumert, T. F.

                              Gastroenterology. 2019 Apr 9. pii: S0016-5085(19)35670-7. doi: 10.1053/j.gastro.2019.04.003.

                              Metabolism of Butyrylfentanyl in Fresh Human Hepatocytes: Chemical Synthesis of Authentic Metabolite Standards for Definitive Identification

                                Kanamori, T. Iwata, Y. T. Segawa, H. Yamamuro, T. Kuwayama, K. Tsujikawa, K. Inoue, H.

                                Biol Pharm Bull. 2019;42(4):623-630. doi: 10.1248/bpb.b18-00765.

                                Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver

                                  Nakayama, K. Ito, S. Suzuki, M. Takubo, H. Yamazaki, H. Nomura, Y.

                                  Xenobiotica. 2019 Apr; 49(4):404-414.  doi:10.1080/00498254.2018.1460516. Epub 2018 Apr 19.

                                  PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization

                                    Mueller, H. Lopez, A. Tropberger, P. Wildum, S. Schmaler, J. Pedersen, L. Han, X. Wang, Y. Ottosen, S. Yang, S. Young, J. A. T. Javanbakht, H.

                                    Hepatology. 2019 Apr;69(4):1398-1411. doi: 10.1002/hep.30329. Epub 2019 Mar 1.

                                    HCV-induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

                                      Hamdane, N. Juhling, F. Crouchet, E. El Saghire, H. Thumann, C. Oudot, M. A. Bandiera, S. Saviano, A. Ponsolles, C. Roca Suarez, A. A. Li, S. Fujiwara, N. Ono, A. Davidson, I. Bardeesy, N. Schmidl, C. Bock, C. Schuster, C. Lupberger, J. Habersetzer, F. Doffoel, M. Piardi, T. Sommacale, D. mamura, M. Uchida, T. Ohdan, H. Aikata, H. Chayama, K. Boldanova, T. Pessaux, P. Fuchs, B. C. Hoshida, Y. Zeisel, M. B. Duong, F. H. T. Baumert, T. F.

                                      Gastroenterology. 2019 Mar 2. pii: S0016-5085(19)32506-5. doi: 10.1053/j.gastro.2019.02.038.

                                      An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People

                                        Hayashi, S. Khan, A. Simons, B. C. Homan, C. Matsui, T. Ogawa, K. Kawashima, K. Murakami, S. Takahashi, S. Isogawa, M. Ikeo, K. Mizokami, M. McMahon, B. J. Tanaka, Y.

                                        Hepatology. 2019 Jan;69(1):19-33. doi: 10.1002/hep.30111. Epub 2018 Dec 10.