Phoenix Bio

研究開発

研究開発

Candidate genes responsible for early key events of phenobarbital-promoted mouse hepatocellular tumorigenesis based on differentiation of regulating genes between wild type mice and humanized chimeric mice

    Ohara A , Takahashi Y,  Kondo  M,  Okuda Y, Takeda  S,  Kushida M, Kobayashi  K,  Sumida K, Yamada T

    Toxicol Res. 2017; 6(6): 795-813

    Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin

      Okuda, Y. Kushida, M. Kikumoto, H. Nakamura, Y. Higuchi, H. Kawamura, S. Cohen, S. M. Lake, B. G.Yamada, T.

      J Toxicol Sci. 2017;42(6):773-788. doi: 10.2131/jts.42.773.

      Organic anion transporting polypeptides (OATPs)-mediated drug-drug interaction study between rosuvastatin and cyclosporine A in chimeric mice with humanized liver

        Uchida, M. Tajima, Y. Kakuni, M. Kageyama, Y. Okada, T. Sakudara, E. Tateno, C. Hayashi, R.

        Drug Metab Dispos. 2017 Oct 19. pii: dmd.117.075994. doi: 10.1124/dmd.117.075994.

        Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver

          Sanoh, S. Yamachika, Y. Tamura, Y. Kotake, Y. Yoshizane, Y. Ishida, Y. Tateno, C. Ohta, S.

          J Toxicol Sci. 2017;42(5):589-596. doi: 10.2131/jts.42.589.

          Downregulation of the Complement Cascade In Vitro, in Mice and in Patients with Cardiovascular Disease by the BET Protein Inhibitor Apabetalone (RVX-208)

            Wasiak, S. Gilham, D. Tsujikawa, L. M. Halliday, C. Calosing, C. Jahagirdar, R. Johansson, J. Sweeney, M. Wong, N. C. Kulikowski, E.

            J Cardiovasc Transl Res. 2017 May 31. doi: 10.1007/s12265-017-9755-z.

            Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2

              Nakada, N.

              Pharm Res. 2017 Feb 13. doi: 10.1007/s11095-017-2116-4.

              Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

                Miyamoto, M. Iwasaki, S.  Chisaki, I. Nakagawa, S. Amano, N. Hirabayashi, H.

                Xenobiotica. 2016 Nov 28:1-54.

                Lack of exposure in a first-in-man study due to aldehyde oxidase metabolism: Investigated by use of 14C-microdose, humanized mice, monkey pharmacokinetics and in vitro methods

                  Jensen, K. G. Jacobsen, A. M. Bundgaard, C. Nilausen, D. O. Thale, Z. Chandrasena, G. Jorgensen, M.

                  Drug Metab Dispos. 2016 Oct 13. pii: dmd.116.072793.

                  Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

                    Toyoda, Y. Takada, T. Suzuki, H.

                    Sci Rep. 2016 Apr 18;6:24586. doi: 10.1038/srep24586.

                    Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans

                      Nakada, N. Kawamura, A. Kamimura, H. Sato, K. Kazuki, Y. Kakuni, M. Ohbuchi, M. Kato, K. Tateno, C. Oshimura, M. Usui, T.

                      Biopharm Drug Dispos. 2015 Sep 9. doi: 10.1002/bdd.1990.

                      Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver

                        Kato, K. Ohbuchi, M. Hamamura, S. Ohshita, H. Kazuki, Y. Oshimura, M. Sato, K. Nakada, N. Kawamura, A. Usui, T. Kamimura, H. Tateno, C.

                        Drug Metab Dispos. 2015 Aug;43(8):1208-17.

                         

                        Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans

                          Nakada, N. Oda, K.

                          Xenobiotica. 2015 Apr 14:1-9.

                          Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

                            Sanoh, S. Naritomi, Y. Fujimoto, M. Sato, K. Kawamura, A. Horiguchi, A.Sugihara, K. Kotake, Y. Ohshita, H. Tateno, C. Horie, T. Kitamura, S. Ohta, S.

                            Xenobiotica. 2015 Mar 3:1-10.

                            Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

                              Yamazaki, H. Kuribayashi, S. Inoue, T. Honda,T. Tateno, C. Oofusa, K. Ninomiya, S.Ikedag , T. Izumi, T and Horie, T

                              Toxicology Research

                              Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate Model to Study Human Peroxisome Proliferator-activated Receptor-alpha

                                Tateno, C. Yamamoto, T. Utoh, R. Yamasaki, C. Ishida, Y. Myoken, Y. Oofusa, K. Okada, M. Tsutsui, N. Yoshizato, K.
                                Toxicol Pathol. 2014 Aug 8. pii: 0192623314544378.

                                Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism

                                  Bateman, T. Reddy, V. B. Kakuni, M. Morikawa, Y. Kumar, S.
                                  Drug Metab Dispos. 2014 Jun;42(6):1055-65.

                                  Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS

                                    Ohtsuki, S. Kawakami, H. Inoue, T. Nakamura, K. Tateno, C. Katsukura, Y. Obuchi, W. Uchida, Y. Kamiie, J. Horie, T. Terasaki, T.
                                    Drug Metab Dispos. 2014 Jun;42(6):1039-43.

                                    Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

                                      Masakazu Kakuni, Chihiro Yamasaki, Asato Tachibana, Yasumi Yoshizane, Yuji Ishida and Chise Tateno
                                      Int. J. Mol. Sci. 2014, 15, 58-74

                                      In vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver

                                        Igawa, Y. Fujitani, T. Shah, B. Oo, C. Kanai, Y.
                                        Xenobiotica. 2014 Jan;44(2):154-63.

                                        Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

                                          Barnes, A. J. Baker, D. R. Hobby, K. Ashton, S. Michopoulos, F. Spagou, K. Loftus, N. J. Wilson, I. D.
                                          Xenobiotica. 2014 Jan; 44(2): 174-85.