Phoenix Bio

研究開発

研究開発

Downregulation of the Complement Cascade In Vitro, in Mice and in Patients with Cardiovascular Disease by the BET Protein Inhibitor Apabetalone (RVX-208)

    Wasiak, S. Gilham, D. Tsujikawa, L. M. Halliday, C. Calosing, C. Jahagirdar, R. Johansson, J. Sweeney, M. Wong, N. C. Kulikowski, E.

    J Cardiovasc Transl Res. 2017 May 31. doi: 10.1007/s12265-017-9755-z.

    Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2

      Nakada, N.

      Pharm Res. 2017 Feb 13. doi: 10.1007/s11095-017-2116-4.

      Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

        Miyamoto, M. Iwasaki, S.  Chisaki, I. Nakagawa, S. Amano, N. Hirabayashi, H.

        Xenobiotica. 2016 Nov 28:1-54.

        Lack of exposure in a first-in-man study due to aldehyde oxidase metabolism: Investigated by use of 14C-microdose, humanized mice, monkey pharmacokinetics and in vitro methods

          Jensen, K. G. Jacobsen, A. M. Bundgaard, C. Nilausen, D. O. Thale, Z. Chandrasena, G. Jorgensen, M.

          Drug Metab Dispos. 2016 Oct 13. pii: dmd.116.072793.

          Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

            Toyoda, Y. Takada, T. Suzuki, H.

            Sci Rep. 2016 Apr 18;6:24586. doi: 10.1038/srep24586.

            Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans

              Nakada, N. Kawamura, A. Kamimura, H. Sato, K. Kazuki, Y. Kakuni, M. Ohbuchi, M. Kato, K. Tateno, C. Oshimura, M. Usui, T.

              Biopharm Drug Dispos. 2015 Sep 9. doi: 10.1002/bdd.1990.

              Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver

                Kato, K. Ohbuchi, M. Hamamura, S. Ohshita, H. Kazuki, Y. Oshimura, M. Sato, K. Nakada, N. Kawamura, A. Usui, T. Kamimura, H. Tateno, C.

                Drug Metab Dispos. 2015 Aug;43(8):1208-17.

                 

                Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans

                  Nakada, N. Oda, K.

                  Xenobiotica. 2015 Apr 14:1-9.

                  Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

                    Sanoh, S. Naritomi, Y. Fujimoto, M. Sato, K. Kawamura, A. Horiguchi, A.Sugihara, K. Kotake, Y. Ohshita, H. Tateno, C. Horie, T. Kitamura, S. Ohta, S.

                    Xenobiotica. 2015 Mar 3:1-10.

                    Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

                      Yamazaki, H. Kuribayashi, S. Inoue, T. Honda,T. Tateno, C. Oofusa, K. Ninomiya, S.Ikedag , T. Izumi, T and Horie, T

                      Toxicology Research

                      Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate Model to Study Human Peroxisome Proliferator-activated Receptor-alpha

                        Tateno, C. Yamamoto, T. Utoh, R. Yamasaki, C. Ishida, Y. Myoken, Y. Oofusa, K. Okada, M. Tsutsui, N. Yoshizato, K.
                        Toxicol Pathol. 2014 Aug 8. pii: 0192623314544378.

                        Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism

                          Bateman, T. Reddy, V. B. Kakuni, M. Morikawa, Y. Kumar, S.
                          Drug Metab Dispos. 2014 Jun;42(6):1055-65.

                          Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS

                            Ohtsuki, S. Kawakami, H. Inoue, T. Nakamura, K. Tateno, C. Katsukura, Y. Obuchi, W. Uchida, Y. Kamiie, J. Horie, T. Terasaki, T.
                            Drug Metab Dispos. 2014 Jun;42(6):1039-43.

                            Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

                              Masakazu Kakuni, Chihiro Yamasaki, Asato Tachibana, Yasumi Yoshizane, Yuji Ishida and Chise Tateno
                              Int. J. Mol. Sci. 2014, 15, 58-74

                              In vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver

                                Igawa, Y. Fujitani, T. Shah, B. Oo, C. Kanai, Y.
                                Xenobiotica. 2014 Jan;44(2):154-63.

                                Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

                                  Barnes, A. J. Baker, D. R. Hobby, K. Ashton, S. Michopoulos, F. Spagou, K. Loftus, N. J. Wilson, I. D.
                                  Xenobiotica. 2014 Jan; 44(2): 174-85.

                                  Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes.

                                    Tanoue C, Sugihara K, Uramaru N, Tayama Y, Watanabe Y, Horie T, Ohta S, Kitamura S
                                    Xenobiotica. 2013 Nov;43(11):956-62.

                                    Investigation of Drug-drug Interactions Caused by Human Pregnane X Receptor-mediated Induction of Cytochrome P450 3A4 and 2C Subfamilies in Chimeric Mice with a Humanized Liver.

                                      Hasegawa M, Tahara H, Inoue R, Kakuni M, Tateno C, Ushiki J.
                                      Drug Metab Dispos. 2012 40(3)474-480

                                      Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

                                        Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
                                        Drug Metab Dispos. 2011 40(2)322-8

                                        Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes.

                                          Sanoh S, Nozaki K, Murai H, Terashita S, Teramura T, Ohta S.
                                          Drug Metab Dispos. 2011 40(1)76-82