Phoenix Bio

研究開発

研究開発

Lack of exposure in a first-in-man study due to aldehyde oxidase metabolism: Investigated by use of 14C-microdose, humanized mice, monkey pharmacokinetics and in vitro methods

    Jensen, K. G. Jacobsen, A. M. Bundgaard, C. Nilausen, D. O. Thale, Z. Chandrasena, G. Jorgensen, M.

    Drug Metab Dispos. 2016 Oct 13. pii: dmd.116.072793.

    Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

      Toyoda, Y. Takada, T. Suzuki, H.

      Sci Rep. 2016 Apr 18;6:24586. doi: 10.1038/srep24586.

      Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans

        Nakada, N. Kawamura, A. Kamimura, H. Sato, K. Kazuki, Y. Kakuni, M. Ohbuchi, M. Kato, K. Tateno, C. Oshimura, M. Usui, T.

        Biopharm Drug Dispos. 2015 Sep 9. doi: 10.1002/bdd.1990.

        Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver

          Kato, K. Ohbuchi, M. Hamamura, S. Ohshita, H. Kazuki, Y. Oshimura, M. Sato, K. Nakada, N. Kawamura, A. Usui, T. Kamimura, H. Tateno, C.

          Drug Metab Dispos. 2015 Aug;43(8):1208-17.

           

          Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans

            Nakada, N. Oda, K.

            Xenobiotica. 2015 Apr 14:1-9.

            Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

              Sanoh, S. Naritomi, Y. Fujimoto, M. Sato, K. Kawamura, A. Horiguchi, A.Sugihara, K. Kotake, Y. Ohshita, H. Tateno, C. Horie, T. Kitamura, S. Ohta, S.

              Xenobiotica. 2015 Mar 3:1-10.

              Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

                Yamazaki, H. Kuribayashi, S. Inoue, T. Honda,T. Tateno, C. Oofusa, K. Ninomiya, S.Ikedag , T. Izumi, T and Horie, T

                Toxicology Research

                Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate Model to Study Human Peroxisome Proliferator-activated Receptor-alpha

                  Tateno, C. Yamamoto, T. Utoh, R. Yamasaki, C. Ishida, Y. Myoken, Y. Oofusa, K. Okada, M. Tsutsui, N. Yoshizato, K.
                  Toxicol Pathol. 2014 Aug 8. pii: 0192623314544378.

                  Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism

                    Bateman, T. Reddy, V. B. Kakuni, M. Morikawa, Y. Kumar, S.
                    Drug Metab Dispos. 2014 Jun;42(6):1055-65.

                    Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS

                      Ohtsuki, S. Kawakami, H. Inoue, T. Nakamura, K. Tateno, C. Katsukura, Y. Obuchi, W. Uchida, Y. Kamiie, J. Horie, T. Terasaki, T.
                      Drug Metab Dispos. 2014 Jun;42(6):1039-43.

                      Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

                        Masakazu Kakuni, Chihiro Yamasaki, Asato Tachibana, Yasumi Yoshizane, Yuji Ishida and Chise Tateno
                        Int. J. Mol. Sci. 2014, 15, 58-74

                        In vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver

                          Igawa, Y. Fujitani, T. Shah, B. Oo, C. Kanai, Y.
                          Xenobiotica. 2014 Jan;44(2):154-63.

                          Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

                            Barnes, A. J. Baker, D. R. Hobby, K. Ashton, S. Michopoulos, F. Spagou, K. Loftus, N. J. Wilson, I. D.
                            Xenobiotica. 2014 Jan; 44(2): 174-85.

                            Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes.

                              Tanoue C, Sugihara K, Uramaru N, Tayama Y, Watanabe Y, Horie T, Ohta S, Kitamura S
                              Xenobiotica. 2013 Nov;43(11):956-62.

                              Investigation of Drug-drug Interactions Caused by Human Pregnane X Receptor-mediated Induction of Cytochrome P450 3A4 and 2C Subfamilies in Chimeric Mice with a Humanized Liver.

                                Hasegawa M, Tahara H, Inoue R, Kakuni M, Tateno C, Ushiki J.
                                Drug Metab Dispos. 2012 40(3)474-480

                                Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

                                  Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
                                  Drug Metab Dispos. 2011 40(2)322-8

                                  Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes.

                                    Sanoh S, Nozaki K, Murai H, Terashita S, Teramura T, Ohta S.
                                    Drug Metab Dispos. 2011 40(1)76-82

                                    Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.

                                      Schulz-Utermoehl T, Sarda S, Foster JR, Jacobsen M, Kenna JG, Morikawa Y, Salmu J, Gross G, Wilson ID.
                                      Xenobiotica. 2012 Jun;42(6):503-17.

                                      Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes.

                                        Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Uramaru N, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
                                        Drug Metab Dispos. 2012 Dec;40(12):2267-72.

                                        Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

                                          Samuelsson K, Pickup K, Sarda S, Swales JG, Morikawa Y, Schulz-Utermoehl T, Hutchison M, Wilson ID.
                                          Xenobiotica. 2012 Nov;42(11):1128-37.