Phoenix Bio

研究開発

研究開発

Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes.

    Tanoue C, Sugihara K, Uramaru N, Tayama Y, Watanabe Y, Horie T, Ohta S, Kitamura S
    Xenobiotica. 2013 Nov;43(11):956-62.

    Investigation of Drug-drug Interactions Caused by Human Pregnane X Receptor-mediated Induction of Cytochrome P450 3A4 and 2C Subfamilies in Chimeric Mice with a Humanized Liver.

      Hasegawa M, Tahara H, Inoue R, Kakuni M, Tateno C, Ushiki J.
      Drug Metab Dispos. 2012 40(3)474-480

      Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

        Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
        Drug Metab Dispos. 2011 40(2)322-8

        Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes.

          Sanoh S, Nozaki K, Murai H, Terashita S, Teramura T, Ohta S.
          Drug Metab Dispos. 2011 40(1)76-82

          Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.

            Schulz-Utermoehl T, Sarda S, Foster JR, Jacobsen M, Kenna JG, Morikawa Y, Salmu J, Gross G, Wilson ID.
            Xenobiotica. 2012 Jun;42(6):503-17.

            Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes.

              Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Uramaru N, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
              Drug Metab Dispos. 2012 Dec;40(12):2267-72.

              Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

                Samuelsson K, Pickup K, Sarda S, Swales JG, Morikawa Y, Schulz-Utermoehl T, Hutchison M, Wilson ID.
                Xenobiotica. 2012 Nov;42(11):1128-37.

                Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton’s tyrosine kinase inhibitor.

                  Liu L, Halladay JS, Shin Y, Wong S, Coraggio M, La H, Baumgardner M, Le H, Gopaul S, Boggs J, Kuebler P, Davis JC Jr, Liao XC, Lubach JW, Deese A, Sowell CG, Currie KS, Young WB, Khojasteh SC, Hop CE, Wong H.
                  Drug Metab Dispos. 2011 Oct;39(10):1840-9.

                  Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism.

                    De Serres M, Bowers G, Boyle G, Beaumont C, Castellino S, Sigafoos J, Dave M, Roberts A, Shah V, Olson K, Patel D, Wagner D, Yeager R, Serabjit-Singh C.
                    Xenobiotica. 2011 Jun;41(6):464-75.

                    In vitro evaluation of cytochrome p450 and glucuronidation activities in hepatocytes isolated from liver-humanized mice.

                      Yamasaki C, Kataoka M, Kato Y, Kakuni M, Usuda S, Ohzone Y, Matsuda S, Adachi Y, Ninomiya S, Itamoto T, Asahara T, Yoshizato K, Tateno C.
                      Drug Metab Pharmacokinet. 2011 Jan 14;25(6):539-50

                      Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity: A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver.

                      Nurrochmad A, Ishii Y, Nakanoh H, Inoue T, Horie T, Sugihara K, Ohta S, Taketomi A, Maehara Y, Yamada H.
                      Drug Metab Pharmacokinet. in press.

                      Approach for in vivo protein binding of 5-n-butyl-pyrazolo[1,5-a]pyrimidine bioactivated in chimeric mice with humanized liver by two-dimensional electrophoresis with accelerator mass spectrometry.

                        Yamazaki H, Kuribayashi S, Inoue T, Tateno C, Nishikura Y, Oofusa K, Harada D, Naito S, Horie T, Ohta S.
                        Chem Res Toxicol. 2010 Jan;23(1):152-8.

                        CYP1A1 and CYP1A2 expression: comparing ‘humanized’ mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines.

                          Uno S, Endo K, Ishida Y, Tateno C, Makishima M, Yoshizato K, Nebert DW.
                          Toxicol Appl Pharmacol. 2009 May 15;237(1):119-26.

                          Prediction of Human Disposition toward S-3H-Warfarin using Chimeric Mice with Humanized Liver

                            Tae INOUE, Kazumi SUGIHARA, Hiroki OHSHITA, Toru HORIE, Shigeyuki KITAMURA and Shigeru OHTA
                            Drug Metabolism and Pharmacokinetics Vol. 24 (2009) , No. 2 pp.153-160

                            CYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized Liver.

                              Inoue T, Nitta K, Sugihara K, Horie T, Kitamura S, Ohta S.
                              Drug Metab Dispos. 2008 Dec;36(12):2429-2433

                              Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.

                                Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Takeda K, Utsunomiya H, Oda K, Warabi E, Ishii T, Osaka K, Hyodo I, Yamamoto M.
                                Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G735-47. Epub 2008 Aug 7.

                                Aldehyde oxidase-catalyzed metabolism of N1-methylnicotinamide in vivo and in vitro in chimeric mice with humanized liver.

                                  Kitamura S, Nitta K, Tayama Y, Tanoue C, Sugihara K, Inoue T, Horie T, Ohta S.
                                  Drug Metab Dispos. 2008 Jul;36(7):1202-5

                                  Human hepatocytes can repopulate mouse liver: histopathology of the liver in human hepatocyte-transplanted chimeric mice and toxicologic responses to acetaminophen.

                                    Sato Y, Yamada H, Iwasaki K, Tateno C, Yokoi T, Yoshizato K, Horii I.
                                    Toxicol Pathol. 2008;36(4):581-91.

                                    Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver

                                      Emoto C, Yamato Y, Sato Y, Ohshita H, Katoh M, Tateno C, Yokoi T, Yoshizato K, Iwasaki K.
                                      Xenobiotica. 2008 Mar;38(3):239-48.

                                      Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers.

                                        Okada K, Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, Takahashi H, Utsunomiya H, Oda K, Sato K, Watanabe A, Ishii T, Itoh K, Yamamoto M, Yokoi T, Yoshizato K, Sugiyama Y, Suzuki H.

                                        Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1450-1463.