Phoenix Bio

研究開発

研究開発

Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice

    Uchida, T. Hiraga, N. Imamura, M. Tsuge, M. Abe, H. Hayes, C. N. Aikata, H. Ishida, Y. Tateno, C. Yoshizato, K. Ohdan, H. Murakami, K. Chayama, K.

    J Virol. 2015 Oct;89(19):10087-96. doi: 10.1128/JVI.01126-15. Epub 2015 Aug 5.

    Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

      Yamamoto, N. Sato, Y. Munakata, T. Kakuni, M. Tateno, C. Sanada, T. Hirata, Y. Murakami, S.  Tanaka, Y. Chayama, K. Hatakeyama, H. Hyodo, M. Harashima, H. Kohara, M.

      J Hepatol. 2015 Oct 23. pii: S0168-8278(15)00713-8. doi: 10.1016/j.jhep.2015.10.014.

      Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones

        Murakami, E. Tsuge, M. Hiraga,  N.Kan, H. Uchida, T. Masaki, K. Nakahara, T. Ono, A. Miki, D. Kawaoka, T. Abe, H.Imamura, M. Aikata, H. Ochi, H. Hayes, C. N. Akita, T. Tanaka, J. Chayama, K.

        J Infect. 2015 Oct 26. pii: S0163-4453(15)00339-4. doi: 10.1016/j.jinf.2015.09.038.

        A novel reporter system to monitor early stages of the HBV life cycle

          Nishitsuji, H. Ujino, S. Shimizu, Y. Harada, K. Zhang, J. Sugiyama, M. Mizokami, M. Shimotohno, K.

          Cancer Sci. 2015 Aug 27. doi: 10.1111/cas.12799.

          第63回日本ウイルス学会学術集会でのPXBマウス・PXB-cells関連研究発表のご案内

          2015年 11月22日(日)~24日(火)に福岡国際会議場(福岡市博多区)にて開催の第63回日本ウイルス学会学術集会にてPXBマウス・PXB-cells関連研究発表がありましたので、ご案内申し上げます。

          Lack of infectivity of HBV in feces from patients with chronic hepatitis B virus infection, and infection using chimeric mice

            Komatsu, H. Inui, A. Murano, T. Tsunoda, T. Sogo, T. Fujisawa, T.

            BMC Res Notes. 2015 Aug 20;8:366. doi: 10.1186/s13104-015-1337-z.

            Characterization of novel entecavir resistance mutations

              Hayashi, S. Murakami, S. Omagari, K. Matsui, T. Iio, E. Isogawa, M. Watanabe, T. Karino, Y. Tanaka, Y.

              J Hepatol. 2015 Sep;63(3):546-53. doi: 10.1016/j.jhep.2015.03.020. Epub 2015 Mar 25.

              Association between hepatitis B virus and MHC class I polypeptide-related chain A in human hepatocytes derived from human-mouse chimeric mouse liver

                Sasaki, R. Kanda, T. Wu, S. Nakamoto, S. Haga, Y. Jiang, X. Nakamura, M.

                Shirasawa, H. Yokosuka, O.

                Journal: Biochem Biophys Res Commun. 2015 Jul 23. pii: S0006-291X(15)30332-6.

                doi: 10.1016/j.bbrc.2015.07.102.

                4′-modified nucleoside analogs: Potent inhibitors active against entecavir-resistant hepatitis B virus

                  Takamatsu, Y. Tanaka, Y. Kohgo, S. Murakami, S. Singh, K. Das, D. Venzon, D.  J. Amano, M. Kuwata,N. Aoki, M. Delino, N. S. Hayashi, S. Takahashi, S. Sukenaga, Y. Haraguchi, K. Sarafianos, S. G. Maeda, K. Mitsuya, H.

                  Journal: Hepatology. 2015 Jun 29. doi: 10.1002/hep.27962.

                  Postexposure Prophylactic Effect of Hepatitis B Virus (HBV)-Active Antiretroviral Therapy against HBV Infection

                    Watanabe, T. Hamada-Tsutsumi, S. Yokomaku, Y. Imamura, J. Sugiura, W. Tanaka, Y.

                    Antimicrob Agents Chemother. 2015 Feb;59(2):1292-8.

                    Discovering novel direct acting antiviral agents for HBV using in silico screening

                      Murakami, Y. Hayakawa, M. Yano, Y. Tanahashi, T. Enomoto, M. Tamori, A. Kawada, N. Iwadate, M. Umeyama, H.

                      Biochem Biophys Res Commun. 2015 Jan 2;456(1):20-8.

                      Novel robust in vitro hepatitis B virus infection model using fresh human hepatocytes isolated from humanized mice

                        Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K, Tateno C

                        Am J Pathol. 2015 May;185(5):1275-85. doi: 10.1016/j.ajpath.2015.01.028. Epub 2015 Mar 17.

                        The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

                          Sato, S. Li, K. Kameyama, T. Hayashi, T. Ishida, Y. Murakami, S. Watanabe, T. Iijima, S. Sakurai, Y. Watashi, K. Tsutsumi, S. Sato, Y. Akita, H. Wakita, T. Rice, C. M. Harashima, H. Kohara, M.Tanaka, Y.Takaoka, A.

                          Immunity. 2015 Jan 20;42(1):123-32.

                          Validation of cross-genotype neutralization by hepatitis B virus-specific monoclonal antibodies by in vitro and in vivo infection

                            Hamada-Tsutsumi, S. Iio, E. Watanabe, T. Murakami, S. Isogawa, M. Iijima, S. Inoue, T. Matsunami, K. Tajiri, K. Ozawa, T. Kishi, H. Muraguchi, A. Joh, T. Tanaka, Y.

                            PLoS One. 2015 Feb 18;10(2):e0118062.

                            Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA

                              Kohno, T. Tsuge, M. Murakami, E. Hiraga, N. Abe, H. Miki, D. Imamura, M. Ochi,

                              H. Hayes, C. N. Chayama, K.

                              J Viral Hepat. 2014 Sep;21(9):e89-97. doi: 10.1111/jvh.12240. Epub 2014 May 16.

                              Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)

                                Watashi, K. Sluder, A. Daito, T. Matsunaga, S. Ryo, A. Nagamori, S. wamoto, M. Nakajima, S. Tsukuda, S. Borroto-Esoda, K. Sugiyama, M. Tanaka, Y. Kanai, Y. Kusuhara, H. Mizokami, M. Wakita, T.

                                Hepatology. 2014 May;59(5):1726-37.

                                Severe necroinflammatory reaction caused by natural killer by Fas/FasL interaction and dendritic cells in human hepatocyte chimeric mouse.

                                  Okazaki A, Hiraga N, Imamura M, Nelson Hayes C, Tsuge M, Takahashi S, Aikata H, Abe H, Miki D, Ochi H, Tateno C, Yoshizato K, Ohdan H, Chayama K.
                                  Hepatology. 2012 Aug;56(2):555-66.

                                  Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice.

                                    Tsuge M, Takahashi S, Hiraga N, Fujimoto Y, Zhang Y, Mitsui F, Abe H, Kawaoka T, Imamura M, Ochi H, Hayes CN, Chayama K.
                                    J Infect Dis. 2011 Jul 15;204(2):224-8.

                                    Transmissibility of hepatitis B virus (HBV) infection through blood transfusion from blood donors with occult HBV infection.

                                      Yuen MF, Wong DK, Lee CK, Tanaka Y, Allain JP, Fung J, Leung J, Lin CK, Sugiyama M, Sugauchi F, Mizokami M, Lai CL.
                                      Clin Infect Dis. 2011 Mar;52(5):624-32

                                      Cross-species transmission of gibbon and orangutan hepatitis B virus to uPA/SCID mice with human hepatocytes.

                                        Sa-Nguanmoo P, Tanaka Y, Ratanakorn P, Sugiyama M, Murakami S, Payungporn S, Sommanustweechai A, Mizokami M, Poovorawan Y.
                                        Virus Res. 2011 Jun;158(1-2):209-15