A novel evaluation method for determining drug-induced hepatotoxicity using 3D bio-printed human liver tissue |
Ide, I. Nagao, E. Kajiyama, S. Mizoguchi, N. |
Toxicol Mech Methods. 2020 Mar;30(3):189-196. doi: 10.1080/15376516.2019.1686795. Epub 2019 Nov 21. |
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Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus |
Matsunaga, S. Jeremiah, S. S. Miyakawa, K. Kurotaki, D. Shizukuishi, S. Watashi, K. Nishitsuji, H. Kimura, H. Tamura, T. Yamamoto, N. Shimotohno, K. Wakita, T. Ryo, A. |
iScience. 2020 Mar 27;23(3):100867. doi: 10.1016/j.isci.2020.100867. Epub 2020 Feb 26. |
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Lipoprotein profile and lipid metabolism of PXB-cells((R)), human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs |
Hata, K. Sayaka, T. Takahashi, M. Sasaki, A. Umekawa, Y. Miyashita, K. Ogura, K. Toshima, G. Maeda, M. Takahashi, J. Kakuni, M. |
Biomed Res. 2020;41(1):33-42. doi: 10.2220/biomedres.41.33. |
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Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver |
Ikeyama, Y. Sato, T. Takemura, A. Sekine, S. Ito, K. |
Toxicol In Vitro. 2020 Jan 25:104785. doi: 10.1016/j.tiv.2020.104785. |
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High-throughput screening to evaluate inhibition of bile acid transporters using human hepatocytes isolated from chimeric mice |
Kohara, H. Bajaj, P. Yamanaka, K. Miyawaki, A. Harada, K. Miyamoto, K. Matsui, T. Okai, Y. Wagoner, M. Shinozawa, T. |
Toxicol Sci. 2019 Nov 13. pii: 5625164. doi: 10.1093/toxsci/kfz229. |
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Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes |
Katsuda, T. Matsuzaki, J. Yamaguchi, T. Yamada, Y. Prieto-Vila, M. Hosaka, K. Takeuchi, A. Saito, Y. Ochiya, T. |
Elife. 2019 Aug 8;8 |
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Prediction of Human Hepatic Clearance for Cytochrome P450 Substrates via a New Culture Method Using the Collagen Vitrigel Membrane Chamber and Fresh Hepatocytes Isolated from Liver Humanized Mice |
Watari, R. Kakiki, M. Yamasaki, C. Ishida, Y. Tateno, C. Kuroda, Y. Ishida, S. Kusano, K. |
Biol Pharm Bull. 2019;42(3):348-53 |
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PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization |
Mueller, H. Lopez, A. Tropberger, P. Wildum, S. Schmaler, J. Pedersen, L. Han, X. Wang, Y. Ottosen, S. Yang, S. Young, J. A. T. Javanbakht, H. |
Hepatology. 2019 Apr;69(4):1398-1411 |
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Metabolism of Butyrylfentanyl in Fresh Human Hepatocytes: Chemical Synthesis of Authentic Metabolite Standards for Definitive Identification |
Kanamori, T. Iwata, Y. T. Segawa, H. Yamamuro, T. Kuwayama, K. Tsujikawa, K. Inoue, H. |
Biol Pharm Bull. 2019;42(4):623-30 |
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Investigating the hepatitis B virus life cycle using engineered reporter hepatitis B viruses |
Nishitsuji, H. Harada, K. Ujino, S. Zhang, J. Kohara, M. Sugiyama, M. Mizokami, M. Shimotohno, K. |
Cancer Sci. 2018 Jan;109(1):241-49. |
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Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity |
Shimura, S. Watashi, K. Fukano, K. Peel, M. Sluder, A. Kawai, F. Iwamoto, M. Tsukuda, S. Takeuchi, J. S. Miyake, T. Sugiyama, M. Ogasawara, Y. Park, S. Y. Tanaka, Y. Kusuhara, H. Mizokami, M. Sureau, C. Wakita, T. |
J Hepatol. 2016 Nov 24 |
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A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins |
Tsukuda, S. Watashi, K. Hojima, T. Isogawa, M. Iwamoto, M. Omagari, K. Suzuki, R. Aizaki, H. Kojima, S. Sugiyama, M. Saito, A. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T. |
Hepatology. 2016 Nov 18. |
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Transmission of HBV DNA Mediated by Ceramide-Triggered Extracellular Vesicles |
Sanada,Takahiro1,* Hirata, Yuichi1,* Naito, Yutaka 2, Yamamoto,Naoki1, Kikkawa, Yoshiaki3, Ishida, Yuji 4, Yamasaki,Chihiro 4, Tateno, Chise 4, Ochiya, Takahiro 2 and Kohara, Michinori 1 |
Cell Mol Gastroenterol Hepatol. 2016 Oct 24;3(2):272-83 |
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Possible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate Cells |
Sasaki, R. Kanda, T. Nakamura, M. Nakamoto, S. Haga, Y. Wu, S. Shirasawa, H. Yokosuka, O. |
PLoS One. 2016 Jan 5;11(1):e0146314 |
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A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide |
Kaneko, M. Watashi, K. Kamisuki, S. Matsunaga, H. Iwamoto, M. Kawai, F. Ohashi, H. Tsukuda, S. Shimura, S. Suzuki, R. Aizaki, H. Sugiyama, M. Park, S. Y. Ito, T. Ohtani, N. Sugawara, F. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T. |
J Virol. 2015 Dec;89(23):11945-53 |
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Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infectio |
Yamamoto, N. Sato, Y. Munakata, T. Kakuni, M. Tateno, C. Sanada, T. Hirata, Y. Murakami, S. Tanaka, Y. Chayama, K. Hatakeyama, H. Hyodo, M. Harashima, H. Kohara, M. |
J Hepatol. 2015 Oct 23 |
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A novel reporter system to monitor early stages of the HBV life cycle |
Nishitsuji, H. Ujino, S. Shimizu, Y. Harada, K. Zhang, J. Sugiyama, M. Mizokami, M. Shimotohno, K. |
Cancer Sci. 2015 Aug 27. doi: 10.1111/cas.12799. |
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Association between hepatitis B virus and MHC class I polypeptide-related chain A in human hepatocytes derived from human-mouse chimeric mouse liver |
Sasaki, R. Kanda, T. Wu, S. Nakamoto, S. Haga, Y. Jiang, X. Nakamura, M. Shirasawa, H. Yokosuka, O. |
Journal: Biochem Biophys Res Commun. 2015 Jul 23 |
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Novel robust in vitro hepatitis B virus infection model using fresh human hepatocytes isolated from humanized mice |
Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K, Tateno C |
Am J Pathol. 2015 May;185(5):1275-85 |
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In vitro evaluation of cytochrome p450 and glucuronidation activities in hepatocytes isolated from liver-humanized mice. |
Yamasaki C, Kataoka M, Kato Y, Kakuni M, Usuda S, Ohzone Y, Matsuda S, Adachi Y, Ninomiya S, Itamoto T, Asahara T, Yoshizato K, Tateno C. |
Drug Metab Pharmacokinet. 2011 Jan 14;25(6):539-50 |
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