Phoenix Bio

論文一覧

論文一覧

論文一覧

Preclinical characterization andin vivoefficacy of GSK8853, a small molecule inhibitor of the Hepatitis C virus NS4B protein

    Pouliot, Jeffrey J. Thomson, Michael Xie, Mi Horton, Joseph Johnson, John Krull, David Mathis, Amanda Morikawa, Yoshio Parks, Derek Peterson, Richard, Shimada, Takashi Thomas, Elizabeth Vamathevan, Jessica Van Horn, Stephanie Xiong, Zhiping Hamatake, Robert  Peat, Andrew J.

    Antimicrob. Agents Chemother. doi:10.1128/AAC.00813-15

    Association between hepatitis B virus and MHC class I polypeptide-related chain A in human hepatocytes derived from human-mouse chimeric mouse liver

      Sasaki, R. Kanda, T. Wu, S. Nakamoto, S. Haga, Y. Jiang, X. Nakamura, M.

      Shirasawa, H. Yokosuka, O.

      Journal: Biochem Biophys Res Commun. 2015 Jul 23. pii: S0006-291X(15)30332-6.

      doi: 10.1016/j.bbrc.2015.07.102.

      4′-modified nucleoside analogs: Potent inhibitors active against entecavir-resistant hepatitis B virus

        Takamatsu, Y. Tanaka, Y. Kohgo, S. Murakami, S. Singh, K. Das, D. Venzon, D.  J. Amano, M. Kuwata,N. Aoki, M. Delino, N. S. Hayashi, S. Takahashi, S. Sukenaga, Y. Haraguchi, K. Sarafianos, S. G. Maeda, K. Mitsuya, H.

        Journal: Hepatology. 2015 Jun 29. doi: 10.1002/hep.27962.

        Efficient engraftmentof human iPS cell-derived hepatocyte-like cells in uPA/SCID mice by overexpression of FNK, a Bcl-xmutant gene

          Nagamoto, Y. Takayama, K. Tashiro, K. Tateno, C. Sakurai, F. Tachibana, M. Kawabata, K. Ikeda, K. Tanaka, Y. Mizuguchi, H.
          Cell Transplant. 2014 May 6.

          Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver

            Kato, K. Ohbuchi, M. Hamamura, S. Ohshita, H. Kazuki, Y. Oshimura, M. Sato, K. Nakada, N. Kawamura, A. Usui, T. Kamimura, H. Tateno, C.

            Drug Metab Dispos. 2015 Aug;43(8):1208-17.

             

            Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti-CD81 monoclonal antibody

              Ji, C. Liu, Y. Pamulapati, C. Bohini, S. Fertig, G. Schraeml, M. Rubas, W. Brandt, M. Ries, S. Ma, H. Klumpp, K.

              Hepatology. 2015 Apr;61(4):1136-44.

              Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans

                Nakada, N. Oda, K.

                Xenobiotica. 2015 Apr 14:1-9.

                Monoclonal Antibodies against Extracellular Domains of Claudin-1 Block Hepatitis C Virus Infection in a Mouse Model

                  Fukasawa, M. Nagase, S. Shirasago, Y. Iida, M. Yamashita, M. Endo, K. Yagi, K. Suzuki, T. Wakita, T. Hanada, K. Kuniyasu, H. Kondoh, M.

                  J Virol. 2015 May 1;89(9):4866-79.

                  Postexposure Prophylactic Effect of Hepatitis B Virus (HBV)-Active Antiretroviral Therapy against HBV Infection

                    Watanabe, T. Hamada-Tsutsumi, S. Yokomaku, Y. Imamura, J. Sugiura, W. Tanaka, Y.

                    Antimicrob Agents Chemother. 2015 Feb;59(2):1292-8.

                    Discovering novel direct acting antiviral agents for HBV using in silico screening

                      Murakami, Y. Hayakawa, M. Yano, Y. Tanahashi, T. Enomoto, M. Tamori, A. Kawada, N. Iwadate, M. Umeyama, H.

                      Biochem Biophys Res Commun. 2015 Jan 2;456(1):20-8.

                      Novel robust in vitro hepatitis B virus infection model using fresh human hepatocytes isolated from humanized mice

                        Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K, Tateno C

                        Am J Pathol. 2015 May;185(5):1275-85. doi: 10.1016/j.ajpath.2015.01.028. Epub 2015 Mar 17.

                        Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

                          Sanoh, S. Naritomi, Y. Fujimoto, M. Sato, K. Kawamura, A. Horiguchi, A.Sugihara, K. Kotake, Y. Ohshita, H. Tateno, C. Horie, T. Kitamura, S. Ohta, S.

                          Xenobiotica. 2015 Mar 3:1-10.

                          The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

                            Sato, S. Li, K. Kameyama, T. Hayashi, T. Ishida, Y. Murakami, S. Watanabe, T. Iijima, S. Sakurai, Y. Watashi, K. Tsutsumi, S. Sato, Y. Akita, H. Wakita, T. Rice, C. M. Harashima, H. Kohara, M.Tanaka, Y.Takaoka, A.

                            Immunity. 2015 Jan 20;42(1):123-32.

                            Validation of cross-genotype neutralization by hepatitis B virus-specific monoclonal antibodies by in vitro and in vivo infection

                              Hamada-Tsutsumi, S. Iio, E. Watanabe, T. Murakami, S. Isogawa, M. Iijima, S. Inoue, T. Matsunami, K. Tajiri, K. Ozawa, T. Kishi, H. Muraguchi, A. Joh, T. Tanaka, Y.

                              PLoS One. 2015 Feb 18;10(2):e0118062.

                              Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization

                                Hara, Y. Yanatori, I. Ikeda, M. Kiyokage, E. Nishina, S. Tomiyama, Y. Toida, K. Kishi, F. Kato, N. Imamura, M. Chayama, K. Hino, K.

                                Am J Pathol. 2014 Sep 19. pii: S0002-9440(14)00483-0. doi: 10.1016/j.ajpath.2014.07.024.

                                In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus

                                  Watanabe, T. Hatakeyama, H. Matsuda-Yasui, C. Sato, Y. Sudoh, M. Takagi, A. Hirata, Y. Ohtsuki, T. Arai, M. Inoue, K. Harashima, H. Kohara, M.

                                  Sci Rep. 2014 Apr 23;4:4750. doi: 10.1038/srep04750.

                                   

                                   

                                  Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA

                                    Kohno, T. Tsuge, M. Murakami, E. Hiraga, N. Abe, H. Miki, D. Imamura, M. Ochi,

                                    H. Hayes, C. N. Chayama, K.

                                    J Viral Hepat. 2014 Sep;21(9):e89-97. doi: 10.1111/jvh.12240. Epub 2014 May 16.

                                    Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

                                      Yamazaki, H. Kuribayashi, S. Inoue, T. Honda,T. Tateno, C. Oofusa, K. Ninomiya, S.Ikedag , T. Izumi, T and Horie, T

                                      Toxicology Research

                                      Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver

                                        Yamada, T. Okuda, Y. Kushida, M. Sumida, K. Takeuchi, H. Nagahori, H. Fukuda, T. Lake, B. G. Cohen, S. M. Kawamura, S.

                                        Toxicol Sci. 2014 Aug 21. pii: kfu173.

                                        Restorative effect of hair follicular dermal cells on injured human hair follicles in a mouse model

                                          Yamao, M. Inamatsu, M. Okada, T. Ogawa, Y. Ishida, Y. Tateno, C. Yoshizato, K.

                                          Exp Dermatol. 2015 Mar;24(3):225-7.