Thromboxane A2 Synthase Inhibitors Prevent Production of Infectious Hepatitis C Virus in Mice with Humanized Livers.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/23684750

Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chayama K, Hijikata M
Gastroenterology. 2013 Sep;145(3):658-67.e11.

A Serine Palmitoyltransferase Inhibitor Inhibits Hepatitis C Virus Replication in Human Hepatocytes.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/23791700

Katsume A, Tokunaga Y, Hirata Y, Munakata T, Saito M, Hayashi H, Okamoto K, Ohmori Y, Kusanagi I, Fujiwara S, Tsukuda T, Aoki Y, Klumpp K, Tsukiyama-Kohara K, El-Gohary A, Sudoh M, Kohara M.
Gastroenterology. 2013 Oct;145(4):865-73.

Demonstration of hepatitis C virus RNA with in situ hybridization employing a locked nucleic Acid probe in humanized liver of infected chimeric mice and in needle-biopsied human liver.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/23853723

Shiogama K, Inada K, Kohara M, Teramoto H, Mizutani Y, Onouchi T, Tsutsumi Y.
Int J Hepatol. 2013;2013:249535. doi: 10.1155/2013/249535. Epub 2013 Jun 18.

Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/23322441

Shi N, Hiraga N, Imamura M, Hayes CN, Zhang Y, Kosaka K, Okazaki A, Murakami E, Tsuge M, Abe H, Aikata H, Takahashi S, Ochi H, Tateno-Mukaidani C, Yoshizato K, Matsui H, Kanai A, Inaba T, McPhee F, Gao M, Chayama K.
Gut. 2013 Jul;62(7):1055-61

A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/23978259

Yoshizato, K. Tateno, C.

Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1419-35.

Neutralizing antibodies induced by cell culture-derived hepatitis C virus protect against infection in mice

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/23673355

Akazawa D, Moriyama M, Yokokawa H, Omi N, Watanabe N, Date T, Morikawa K, Aizaki H, Ishii K, Kato T, Mochizuki H, Nakamura N, Wakita T
Gastroenterology. 2013 Aug;145(2): 447-455.

Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/23651075

Tanoue C, Sugihara K, Uramaru N, Tayama Y, Watanabe Y, Horie T, Ohta S, Kitamura S
Xenobiotica. 2013 Nov;43(11):956-62.

Synthetic lipophilic antioxidant BO-653 suppresses HCV replication.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/23192857

Yasui F, Sudoh M, Arai M, Kohara M.
J Med Virol. 2013 Feb;85(2):241-9.

Morphological and microarray analyses of human hepatocytes from xenogeneic host livers

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/23147226

Chise Tateno, Fuyuki Miya, Kenjiro Wake, Miho Kataoka, Yuji Ishida, Chihiro Yamasaki, Ami Yanagi,　Masakazu Kakuni,　Eddie Wisse, Fons Verheyen, Kouji Inoue, Kota Sato, Atsushi Kudo, Shigeki Arii,　Toshiyuki Itamoto, Toshimasa Asahara, Tatsuhiko Tsunoda and Katsutoshi Yoshizato
Lab Invest. 2013 Jan;93(1):54-71.

Liver tissue engineering utilizing hepatocytes propagated in mouse livers in vivo.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/22793050

Ohashi K, Tatsumi K, Tateno C, Kataoka M, Utoh R, Yoshizato K, Okano T.
Cell Transplant. 2012;21(2-3):429-36.

Human hepatocyte propagation system in the mouse livers: functional maintenance of the production of coagulation and anticoagulation factors.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/22793051

Tatsumi K, Ohashi K, Tateno C, Yoshizato K, Yoshioka A, Shima M, Okano T.
Cell Transplant. 2012;21(2-3):437-45.

A novel animal model for in vivo study of liver cancer metastasis.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/22876040

Fujiwara S, Fujioka H, Tateno C, Taniguchi K, Ito M, Ohishi H, Utoh R, Ishibashi H, Kanematsu T, Yoshizato K.
World J Gastroenterol. 2012 Aug 7;18(29):3875-82.

Generation and characterization of severe combined immunodeficiency rats.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/22981234

Mashimo T, Takizawa A, Kobayashi J, Kunihiro Y, Yoshimi K, Ishida S, Tanabe K, Yanagi A, Tachibana A, Hirose J, Yomoda J, Morimoto S, Kuramoto T, Voigt B, Watanabe T, Hiai H, Tateno C, Komatsu K, Serikawa T.
Cell Rep. 2012 Sep 27;2(3):685-94.

Investigation of Drug-drug Interactions Caused by Human Pregnane X Receptor-mediated Induction of Cytochrome P450 3A4 and 2C Subfamilies in Chimeric Mice with a Humanized Liver.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/22126990

Hasegawa M, Tahara H, Inoue R, Kakuni M, Tateno C, Ushiki J.
Drug Metab Dispos. 2012 40(3)474-480

Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/22048522

Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
Drug Metab Dispos. 2011 40(2)322-8

Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/21984595

Sanoh S, Nozaki K, Murai H, Terashita S, Teramura T, Ohta S.
Drug Metab Dispos. 2011 40(1)76-82

Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/22201515

Schulz-Utermoehl T, Sarda S, Foster JR, Jacobsen M, Kenna JG, Morikawa Y, Salmu J, Gross G, Wilson ID.
Xenobiotica.　2012 Jun;42(6):503-17.

Novel cell culture-adapted genotype 2a hepatitis C virus infectious clone.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/22787209

Date T, Kato T, Kato J, Takahashi H, Morikawa K, Akazawa D, Murayama A, Tanaka-Kaneko K, Sata T, Tanaka Y, Mizokami M, Wakita T.
J Virol. 2012 Oct;86(19):10805-20.

Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/22936315

Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Uramaru N, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
Drug Metab Dispos. 2012 Dec;40(12):2267-72.

Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/22902350

Masakazu Kakuni, Mayu Morita, Kentaro Matsuo, Yumiko Katoh, Miki Nakajima,Chise Tateno, Tsuyoshi Yokoi
Toxicology Letters 214 (2012) 9-18