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• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25557055

Sato, S. Li, K. Kameyama, T. Hayashi, T. Ishida, Y. Murakami, S. Watanabe, T. Iijima, S. Sakurai, Y. Watashi, K. Tsutsumi, S. Sato, Y. Akita, H. Wakita, T. Rice, C. M. Harashima, H. Kohara, M.Tanaka, Y.Takaoka, A.

Immunity. 2015 Jan 20;42(1):123-32.

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• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25693196

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PLoS One. 2015 Feb 18;10(2):e0118062.

Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25244949

Hara, Y. Yanatori, I. Ikeda, M. Kiyokage, E. Nishina, S. Tomiyama, Y. Toida, K. Kishi, F. Kato, N. Imamura, M. Chayama, K. Hino, K.

Am J Pathol. 2014 Sep 19. pii: S0002-9440(14)00483-0. doi: 10.1016/j.ajpath.2014.07.024.

In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24756133

Watanabe, T. Hatakeyama, H. Matsuda-Yasui, C. Sato, Y. Sudoh, M. Takagi, A. Hirata, Y. Ohtsuki, T. Arai, M. Inoue, K. Harashima, H. Kohara, M.

Sci Rep. 2014 Apr 23;4:4750. doi: 10.1038/srep04750.

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• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24835118

Kohno, T. Tsuge, M. Murakami, E. Hiraga, N. Abe, H. Miki, D. Imamura, M. Ochi,

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J Viral Hepat. 2014 Sep;21(9):e89-97. doi: 10.1111/jvh.12240. Epub 2014 May 16.

Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

• Pub Med URL https://dx.doi.org/10.1039/C4TX00068D

Yamazaki, H. Kuribayashi, S. Inoue, T. Honda,T. Tateno, C. Oofusa, K. Ninomiya, S.Ikedag , T. Izumi, T and Horie, T

Toxicology Research

Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an in vivo Study Using a Chimeric Mouse with Humanized Liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25145657

Yamada, T. Okuda, Y. Kushida, M. Sumida, K. Takeuchi, H. Nagahori, H. Fukuda, T. Lake, B. G. Cohen, S. M. Kawamura, S.

Toxicol Sci. 2014 Aug 21. pii: kfu173.

Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate Model to Study Human Peroxisome Proliferator-activated Receptor-alpha

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25107573

Tateno, C. Yamamoto, T. Utoh, R. Yamasaki, C. Ishida, Y. Myoken, Y. Oofusa, K. Okada, M. Tsutsui, N. Yoshizato, K.
Toxicol Pathol. 2014 Aug 8. pii: 0192623314544378.

Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24478422

Dallas, A. Ilves, H. Ma, H. Chin, D. J. Maclachlan, I. Klumpp, K. Johnston, B. H.
J Virol. 2014 May;88(9):4647-4656.

Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24700822

Bateman, T. Reddy, V. B. Kakuni, M. Morikawa, Y. Kumar, S.
Drug Metab Dispos. 2014 Jun;42(6):1055-65.

Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24711249

Ohtsuki, S. Kawakami, H. Inoue, T. Nakamura, K. Tateno, C. Katsukura, Y. Obuchi, W. Uchida, Y. Kamiie, J. Horie, T. Terasaki, T.
Drug Metab Dispos. 2014 Jun;42(6):1039-43.

Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24114658

Sanoh, S. Ohta, S.
Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24362577

Masakazu Kakuni, Chihiro Yamasaki, Asato Tachibana, Yasumi Yoshizane, Yuji Ishida and Chise Tateno
Int. J. Mol. Sci. 2014, 15, 58-74

Hepatitis Virus Infection Affects DNA Methylation in Mice with Humanized Livers

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24184133

Okamoto, Y. Shinjo, K., Shimizu, Y. Sano, T. Yamao, K. Gao, W. Fujii, M. Osada, H. Sekido, Y. Murakami, S. Tanaka, Y. Joh, T. Sato, S. Takahashi, S. Wakita, T. Zhu, J.Issa, J. P. Kondo, Y.
Gastroenterology. 2014 Feb;146(2):562-72.

Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24279674

Takahashi, Y. Ando, M. Nishikawa, M. Hiraga, N. Imamura, M. Chayama, K. Takakura, Y.

Hum Gene Ther Clin Dev. 2014 Mar;25(1):28-39.

Formulated Minimal-Length Synthetic Small Hairpin RNAs are Potent Inhibitors of Hepatitis C Virus in Mice with Humanized Livers

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24076507

Ma, H. Dallas, A. Ilves, H. Shorenstein, J. Maclachlan, I. Klumpp, K. Johnston, B. H.
Gastroenterology. 2014 Jan;146(1):63-6.

In vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24304169

Igawa, Y. Fujitani, T. Shah, B. Oo, C. Kanai, Y.
Xenobiotica. 2014 Jan;44(2):154-63.

Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24350779

Barnes, A. J. Baker, D. R. Hobby, K. Ashton, S. Michopoulos, F. Spagou, K. Loftus, N. J. Wilson, I. D.
Xenobiotica. 2014 Jan; 44(2): 174-85.

Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24329499

Kitamura, S. Sugihara, K.
Xenobiotica. 2014 Jan; 44(2): 123-34.

Isolation and characterization of highly replicable hepatitis C virus genotype 1a strain HCV-RMT

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24358200

Arai M, Tokunaga Y, Takagi A, Tobita Y, Hirata Y, Ishida Y, TatenoC, Kohara M
PLoS One. 2013 Dec 16;8(12):e82527.