Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

• Pub Med URL http://dx.doi.org/10.1039/C4TX00068D

Yamazaki, H. Kuribayashi, S. Inoue, T. Honda,T. Tateno, C. Oofusa, K. Ninomiya, S.Ikedag , T. Izumi, T and Horie, T

Toxicology Research

Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25145657

Yamada, T. Okuda, Y. Kushida, M. Sumida, K. Takeuchi, H. Nagahori, H. Fukuda, T. Lake, B. G. Cohen, S. M. Kawamura, S.

Toxicol Sci. 2014 Aug 21. pii: kfu173.

Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate Model to Study Human Peroxisome Proliferator-activated Receptor-alpha

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25107573

Tateno, C. Yamamoto, T. Utoh, R. Yamasaki, C. Ishida, Y. Myoken, Y. Oofusa, K. Okada, M. Tsutsui, N. Yoshizato, K.
Toxicol Pathol. 2014 Aug 8. pii: 0192623314544378.

Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24478422

Dallas, A. Ilves, H. Ma, H. Chin, D. J. Maclachlan, I. Klumpp, K. Johnston, B. H.
J Virol. 2014 May;88(9):4647-4656.

Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24700822

Bateman, T. Reddy, V. B. Kakuni, M. Morikawa, Y. Kumar, S.
Drug Metab Dispos. 2014 Jun;42(6):1055-65.

Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24711249

Ohtsuki, S. Kawakami, H. Inoue, T. Nakamura, K. Tateno, C. Katsukura, Y. Obuchi, W. Uchida, Y. Kamiie, J. Horie, T. Terasaki, T.
Drug Metab Dispos. 2014 Jun;42(6):1039-43.

Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24114658

Sanoh, S. Ohta, S.
Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24362577

Masakazu Kakuni, Chihiro Yamasaki, Asato Tachibana, Yasumi Yoshizane, Yuji Ishida and Chise Tateno
Int. J. Mol. Sci. 2014, 15, 58-74

Hepatitis Virus Infection Affects DNA Methylation in Mice with Humanized Livers

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24184133

Okamoto, Y. Shinjo, K., Shimizu, Y. Sano, T. Yamao, K. Gao, W. Fujii, M. Osada, H. Sekido, Y. Murakami, S. Tanaka, Y. Joh, T. Sato, S. Takahashi, S. Wakita, T. Zhu, J.Issa, J. P. Kondo, Y.
Gastroenterology. 2014 Feb;146(2):562-72.

Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24279674

Takahashi, Y. Ando, M. Nishikawa, M. Hiraga, N. Imamura, M. Chayama, K. Takakura, Y.

Hum Gene Ther Clin Dev. 2014 Mar;25(1):28-39.

Formulated Minimal-Length Synthetic Small Hairpin RNAs are Potent Inhibitors of Hepatitis C Virus in Mice with Humanized Livers

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24076507

Ma, H. Dallas, A. Ilves, H. Shorenstein, J. Maclachlan, I. Klumpp, K. Johnston, B. H.
Gastroenterology. 2014 Jan;146(1):63-6.

In vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24304169

Igawa, Y. Fujitani, T. Shah, B. Oo, C. Kanai, Y.
Xenobiotica. 2014 Jan;44(2):154-63.

Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24350779

Barnes, A. J. Baker, D. R. Hobby, K. Ashton, S. Michopoulos, F. Spagou, K. Loftus, N. J. Wilson, I. D.
Xenobiotica. 2014 Jan; 44(2): 174-85.

Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24329499

Kitamura, S. Sugihara, K.
Xenobiotica. 2014 Jan; 44(2): 123-34.

Isolation and characterization of highly replicable hepatitis C virus genotype 1a strain

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24358200

Arai M, Tokunaga Y, Takagi A, Tobita Y, Hirata Y, Ishida Y, TatenoC, Kohara M
PLoS One. 2013 Dec 16;8(12):e82527.

HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-beta type I receptor

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24263861

Sakata, K. Hara, M. Terada, T. Watanabe, N. Takaya, D. Yaguchi, S. Matsumoto, T. Matsuura, T. Shirouzu, M. Yokoyama, S. Yamaguchi, T. Miyazawa, K. Aizaki, H. Suzuki, T. Wakita, T. Imoto, M. Kojima, S.
Sci Rep. 2013 Nov 22;3:3243. doi: 10.1038/srep03243.

Transplantation of engineered chimeric liver with autologous hepatocytes and xenobiotic scaffold

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/22691372

Hata T, Uemoto S, Fujimoto Y, Murakami T, Tateno C, Yoshizato K, Kobayashi E.
Ann Surg. 2013 Mar;257(3):542-7.

Repopulation of the immunosuppressed retrorsine-treated infant rat liver with human hepatocytes.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/23683097

Tachibana A, Tateno C, Yoshizato K.
Xenotransplantation. 2013 Jul;20(4):227-38.

Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/23135762

Watanabe T, Sugauchi F, Tanaka Y, Matsuura K, Yatsuhashi H, Murakami S, Iijima S, Iio E, Sugiyama M, Shimada T, Kakuni M, Kohara M, Mizokami M.
Gut. 2013 Sep;62(9):1340-6

Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/23555725

Nakagawa S, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M.
PLoS One. 2013;8(3):e59611.