Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25869242

Nakada, N. Oda, K.

Xenobiotica. 2015 Apr 14:1-9.

Monoclonal Antibodies against Extracellular Domains of Claudin-1 Block Hepatitis C Virus Infection in a Mouse Model

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25673725

Fukasawa, M. Nagase, S. Shirasago, Y. Iida, M. Yamashita, M. Endo, K. Yagi, K. Suzuki, T. Wakita, T. Hanada, K. Kuniyasu, H. Kondoh, M.

J Virol. 2015 May 1;89(9):4866-79.

Postexposure Prophylactic Effect of Hepatitis B Virus (HBV)-Active Antiretroviral Therapy against HBV Infection

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25512419

Watanabe, T. Hamada-Tsutsumi, S. Yokomaku, Y. Imamura, J. Sugiura, W. Tanaka, Y.

Antimicrob Agents Chemother. 2015 Feb;59(2):1292-8.

Discovering novel direct acting antiviral agents for HBV using in silico screening

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25446116

Murakami, Y. Hayakawa, M. Yano, Y. Tanahashi, T. Enomoto, M. Tamori, A. Kawada, N. Iwadate, M. Umeyama, H.

Biochem Biophys Res Commun. 2015 Jan 2;456(1):20-8.

Novel robust in vitro hepatitis B virus infection model using fresh human hepatocytes isolated from humanized mice

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25791527

Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K, Tateno C

Am J Pathol. 2015 May;185(5):1275-85. doi: 10.1016/j.ajpath.2015.01.028. Epub 2015 Mar 17.

Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25733030

Sanoh, S. Naritomi, Y. Fujimoto, M. Sato, K. Kawamura, A. Horiguchi, A.Sugihara, K. Kotake, Y. Ohshita, H. Tateno, C. Horie, T. Kitamura, S. Ohta, S.

Xenobiotica. 2015 Mar 3:1-10.

The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25557055

Sato, S. Li, K. Kameyama, T. Hayashi, T. Ishida, Y. Murakami, S. Watanabe, T. Iijima, S. Sakurai, Y. Watashi, K. Tsutsumi, S. Sato, Y. Akita, H. Wakita, T. Rice, C. M. Harashima, H. Kohara, M.Tanaka, Y.Takaoka, A.

Immunity. 2015 Jan 20;42(1):123-32.

Validation of cross-genotype neutralization by hepatitis B virus-specific monoclonal antibodies by in vitro and in vivo infection

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25693196

Hamada-Tsutsumi, S. Iio, E. Watanabe, T. Murakami, S. Isogawa, M. Iijima, S. Inoue, T. Matsunami, K. Tajiri, K. Ozawa, T. Kishi, H. Muraguchi, A. Joh, T. Tanaka, Y.

PLoS One. 2015 Feb 18;10(2):e0118062.

Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25244949

Hara, Y. Yanatori, I. Ikeda, M. Kiyokage, E. Nishina, S. Tomiyama, Y. Toida, K. Kishi, F. Kato, N. Imamura, M. Chayama, K. Hino, K.

Am J Pathol. 2014 Sep 19. pii: S0002-9440(14)00483-0. doi: 10.1016/j.ajpath.2014.07.024.

In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24756133

Watanabe, T. Hatakeyama, H. Matsuda-Yasui, C. Sato, Y. Sudoh, M. Takagi, A. Hirata, Y. Ohtsuki, T. Arai, M. Inoue, K. Harashima, H. Kohara, M.

Sci Rep. 2014 Apr 23;4:4750. doi: 10.1038/srep04750.

Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24835118

Kohno, T. Tsuge, M. Murakami, E. Hiraga, N. Abe, H. Miki, D. Imamura, M. Ochi,

H. Hayes, C. N. Chayama, K.

J Viral Hepat. 2014 Sep;21(9):e89-97. doi: 10.1111/jvh.12240. Epub 2014 May 16.

Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

• Pub Med URL https://dx.doi.org/10.1039/C4TX00068D

Yamazaki, H. Kuribayashi, S. Inoue, T. Honda,T. Tateno, C. Oofusa, K. Ninomiya, S.Ikedag , T. Izumi, T and Horie, T

Toxicology Research

Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an in vivo Study Using a Chimeric Mouse with Humanized Liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25145657

Yamada, T. Okuda, Y. Kushida, M. Sumida, K. Takeuchi, H. Nagahori, H. Fukuda, T. Lake, B. G. Cohen, S. M. Kawamura, S.

Toxicol Sci. 2014 Aug 21. pii: kfu173.

Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate Model to Study Human Peroxisome Proliferator-activated Receptor-alpha

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25107573

Tateno, C. Yamamoto, T. Utoh, R. Yamasaki, C. Ishida, Y. Myoken, Y. Oofusa, K. Okada, M. Tsutsui, N. Yoshizato, K.
Toxicol Pathol. 2014 Aug 8. pii: 0192623314544378.

Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24478422

Dallas, A. Ilves, H. Ma, H. Chin, D. J. Maclachlan, I. Klumpp, K. Johnston, B. H.
J Virol. 2014 May;88(9):4647-4656.

Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24700822

Bateman, T. Reddy, V. B. Kakuni, M. Morikawa, Y. Kumar, S.
Drug Metab Dispos. 2014 Jun;42(6):1055-65.

Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24711249

Ohtsuki, S. Kawakami, H. Inoue, T. Nakamura, K. Tateno, C. Katsukura, Y. Obuchi, W. Uchida, Y. Kamiie, J. Horie, T. Terasaki, T.
Drug Metab Dispos. 2014 Jun;42(6):1039-43.

Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24114658

Sanoh, S. Ohta, S.
Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24362577

Masakazu Kakuni, Chihiro Yamasaki, Asato Tachibana, Yasumi Yoshizane, Yuji Ishida and Chise Tateno
Int. J. Mol. Sci. 2014, 15, 58-74

Hepatitis Virus Infection Affects DNA Methylation in Mice with Humanized Livers

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24184133

Okamoto, Y. Shinjo, K., Shimizu, Y. Sano, T. Yamao, K. Gao, W. Fujii, M. Osada, H. Sekido, Y. Murakami, S. Tanaka, Y. Joh, T. Sato, S. Takahashi, S. Wakita, T. Zhu, J.Issa, J. P. Kondo, Y.
Gastroenterology. 2014 Feb;146(2):562-72.