Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/20164258

Kamiya N, Iwao E, Hiraga N, Tsuge M, Imamura M, Takahashi S, Miyoshi S, Tateno C, Yoshizato K, Chayama K.
J Gen Virol. 2010 Jul;91(Pt 7):1668-77. Epub 2010 Feb 17.

In vivo stable transduction of humanized liver tissue in chimeric mice via high-capacity adenovirus-lentivirus hybrid vector.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/19725756

Kubo S, Kataoka M, Tateno C, Yoshizato K, Kawasaki Y, Kimura T, Faure-Kumar E, Palmer DJ, Ng P, Okamura H, Kasahara N.

Hum Gene Ther. 2010 Jan;21(1):40-50.

Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity: A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver.

Nurrochmad A, Ishii Y, Nakanoh H, Inoue T, Horie T, Sugihara K, Ohta S, Taketomi A, Maehara Y, Yamada H.
Drug Metab Pharmacokinet. in press.

ヒト型肝臓を持つキメラマウスから分離したヒト肝細胞のCYPおよびUGT活性の評価

Yamasaki, C., et al

DMPK. 2010; 6:45

Approach for in vivo protein binding of 5-n-butyl-pyrazolo[1,5-a]pyrimidine bioactivated in chimeric mice with humanized liver by two-dimensional electrophoresis with accelerator mass spectrometry.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/19928966

Yamazaki H, Kuribayashi S, Inoue T, Tateno C, Nishikura Y, Oofusa K, Harada D, Naito S, Horie T, Ohta S.
Chem Res Toxicol. 2010 Jan;23(1):152-8.

Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/19853955?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.P

Hiraga N, Imamura M, Hatakeyama T, Kitamura S, Mitsui F, Tanaka S, Tsuge M, Takahashi S, Abe H, Maekawa T, Ochi H, Tateno C, Yoshizato K, Wakita T, Chayama K.
J Hepatol. 2009 Dec;51(6):1046-54. Epub 2009 Sep 23.

A human hepatocyte-bearing mouse: an animal model to predict drug metabolism and effectiveness in humans.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/19884982

Yoshizato K, Tateno C.

PPAR Res.2009:476217. Epub 2009 Oct 26.

Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/19394333

Matsumura T, Hu Z, Kato T, Dreux M, Zhang YY, Imamura M, Hiraga N, Juteau JM, Cosset FL, Chayama K, Vaillant A, Liang TJ.
Gastroenterology. 2009 Aug;137(2):673-81

Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/19805910

Ohira M, Ishiyama K, Tanaka Y, Doskali M, Igarashi Y, Tashiro H, Hiraga N, Imamura M, Sakamoto N, Asahara T, Chayama K, Ohdan H.

J Clin Invest. 2009 Nov;119(11):3226-35.

A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/19640977

Tatematsu K, Tanaka Y, Kurbanov F, Sugauchi F, Mano S, Maeshiro T, Nakayoshi T, Wakuta M, Miyakawa Y, Mizokami M.

J Virol. 2009 Oct;83(20):10538-47.

CYP1A1 and CYP1A2 expression: comparing ‘humanized’ mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/18248870?ordinalpos=14&itool=EntrezSystem

Uno S, Endo K, Ishida Y, Tateno C, Makishima M, Yoshizato K, Nebert DW.
Toxicol Appl Pharmacol. 2009 May 15;237(1):119-26.

Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/19041311?ordinalpos=1&itool=EntrezSystem2

Sugiyama M, Tanaka Y, Kurbanov F, Maruyama I, Shimada T, Takahashi S, Shirai T, Hino K, Sakaida I, Mizokami M.
Gastroenterology. 2009 Feb;136(2):652-62

ヒト肝キメラマウスの特性

特免編集部

シリーズIII: 継続・肝炎ウイルス十話＿第一話

Prediction of Human Disposition toward S-3H-Warfarin using Chimeric Mice with Humanized Liver

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/19430171?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Tae INOUE, Kazumi SUGIHARA, Hiroki OHSHITA, Toru HORIE, Shigeyuki KITAMURA and Shigeru OHTA
Drug Metabolism and Pharmacokinetics Vol. 24 (2009) , No. 2 pp.153-160

Titration of hepatitis B virus infectivity in the sera of pre-acute and late acute phases of HBV infection: transmission experiments to chimeric mice with human liver repopulated hepatocytes.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/19040280?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Tabuchi A, Tanaka J, Katayama K, Mizui M, Matsukura H, Yugi H, Shimada T, Miyakawa Y, Yoshizawa H.
J Med Virol. 2008 Dec;80(12):2064-8.

CYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized Liver.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/18784266?ordinalpos=1&itool=EntrezSystem2

Inoue T, Nitta K, Sugihara K, Horie T, Kitamura S, Ohta S.
Drug Metab Dispos. 2008 Dec;36(12):2429-2433

Molecular epidemiology and interferon susceptibility of the natural recombinant hepatitis C virus strain RF1_2k/1b.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/18928375?ordinalpos=9&itool=EntrezSystem2

Kurbanov F, Tanaka Y, Chub E, Maruyama I, Azlarova A, Kamitsukasa H, Ohno T, Bonetto S, Moreau I, Fanning LJ, Legrand-Abravanel F, Izopet J, Naoumov N, Shimada T, Netesov S, Mizokami M.
J Infect Dis. 2008 Nov 15;198(10):1448-56.

Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/18687751?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Takeda K, Utsunomiya H, Oda K, Warabi E, Ishii T, Osaka K, Hyodo I, Yamamoto M.
Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G735-47. Epub 2008 Aug 7.

Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/18753219?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Kimura T, Imamura M, Hiraga N, Hatakeyama T, Miki D, Noguchi C, Mori N, Tsuge M, Takahashi S, Fujimoto Y, Iwao E, Ochi H, Abe H, Maekawa T, Arataki K, Tateno C, Yoshizato K, Wakita T, Okamoto T, Matsuura Y, Chayama K.
J Gen Virol. 2008 Sep;89(Pt 9):2108-13.

Aldehyde oxidase-catalyzed metabolism of N1-methylnicotinamide in vivo and in vitro in chimeric mice with humanized liver.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/18332084?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Kitamura S, Nitta K, Tayama Y, Tanoue C, Sugihara K, Inoue T, Horie T, Ohta S.
Drug Metab Dispos. 2008 Jul;36(7):1202-5