Evaluation of human hepatocyte chimeric mice as a model for toxicological investigation using panomic approaches–effect of acetaminophen on the expression profiles of proteins and endogenous metabolites in liver, plasma and urine

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17785938&ordinalp=

Yamamoto T, Tomizawa K, Fujikawa M, Sato Y, Yamada H, Horii I.
J Toxicol Sci. 2007 Aug;32(3):205-15.

Bezafibrate induces multidrug-resistance P-Glycoprotein 3 expression in cultured human hepatocytes and humanized livers of chimeric mice.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/17539998?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Shoda J, Okada K, Inada Y, Kusama H, Utsunomiya H, Oda K, Yokoi T, Yoshizato K, Suzuki H.
Hepatol Res. 2007 Jul;37(7):548-56.

Humanization of Excretory Pathway in Chimeric Mice with Humanized Liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17341479&ordinalp=

Okumura H, Katoh M, Sawada T, Nakajima M, Soeno Y, Yabuuchi H, Ikeda T, Tateno C, Yoshizato K, Yokoi T.
Toxicol Sci. 2007 Jun;97(2):533-8. Epub 2007 Mar 6.

Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C Virus and its susceptibility to interferon

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17466983&ordinalp=

Hiraga N, Imamura M, Tsuge M, Noguchi C, Takahashi S, Iwao E, Fujimoto Y, Abe H, Maekawa T, Ochi H, Tateno C, Yoshizato K, Sakai A, Sakai Y, Honda M, Kaneko S, Wakita T, Chayama K.
FEBS Lett. 2007 May 15;581(10):1983-7. Epub 2007 Apr 20.

Early Dynamics of Hepatitis B Virus in Chimeric Mice Carrying Human Hepatocytes Monoinfected or Coinfected with Genotype G

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17393501&ordinalp=

Sugiyama M, Tanaka Y, Sakamoto T, Maruyama I, Shimada T, Takahashi S, Shirai T, Kato H, Nagao M, Miyakawa Y, Mizokami M.
Hepatology. 2007 Apr;45(4):929-37.

Evaluation of Cyclophilin Inhibitor in Hepatitis C Virus-Infected Chimeric Mice In Vivo

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17393519&ordinalp=

Inoue K, Umehara T, Ruegg UT, Yasui F, Watanabe T, Yasuda H, Dumont JM, Scalfaro P, Yoshiba M, Kohara M.
Hepatology. 2007 Apr;45(4):921-8.

Humanized mice in translational biomedical research.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/17259968?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Shultz LD, Ishikawa F, Greiner DL.
Nat Rev Immunol. 2007 Feb;7(2):118-30.

Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17196931&ordinalp=

Nakagawa S, Umehara T, Matsuda C, Kuge S, Sudoh M, Kohara M.
Biochem Biophys Res Commun. 2007 Feb 23;353(4):882-8. Epub 2006 Dec 22.

Application of chimeric mice with humanized liver for predictive adme

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17364883&ordinalp=

Katoh M, Yokoi T.
Drug Metab Rev. 2007;39(1):145-57.

Influence of Hepatitis B Virus Genotypes on the Intra- and Extracellular Expression of Viral DNA and Antigens

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/17006908

Sugiyama M, Tanaka Y, Kato T, Orito E, Ito K, Acharya SK, Gish RG, Kramvis A, Shimada T, Izumi N, Kaito M, Miyakawa Y, Mizokami M.

Hepatology. 2006 Oct;44(4):915-24.

Evaluation of Human CYP1A2 and CYP3A4 mRNA Expression in Hepatocytes from Chimeric Mice with Humanized Liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/17220562

Yoshitsugu H, Nishimura M, Tateno C, Kataoka M, Takahashi E, Soeno Y, Yoshizato K, Yokoi T, Naito S.

Drug Metab Pharmacokinet. 2006;21(6):465-474.

Emergence of a Novel Lamivudine-Resistant Hepatitis B Virus Variant with a Substitution Outside the YMDD Motif

• Pub Med URL https://www.phoenixbio.co.jp/en/rd/thesis/jqunv80000000rv3.html

Yatsuji H, Noguchi C, Hiraga N, Mori N, Tsuge M, Imamura M, Takahashi S, Iwao E, Fujimoto Y, Ochi H, Abe H, Maekawa T, Tateno C, Yoshizato K, Suzuki F, Kumada H, Chayama K.
Antimicrob Agents Chemother. 2006 Nov;50(11):3867-74. Epub 2006 Sep 18.

Characterization of Humanized Liver from Chimeric Mice Using Coumarin as a Human CYP2A6 and Mouse CYP2A5 Probe

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/16946554

Aoki K, Kashiwagura Y, Horie T, Sato H, Tateno C, Ozawa N, Yoshizato K.

Drug Metab Pharmacokinet. 2006 ;21(4):277-285.

Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/16750511

Umehara T, Sudoh M, Yasui F, Matsuda C, Hayashi Y, Chayama K, Kohara M.

Biochem Biophys Res Commun. 2006 Jul 21;346(1):67-73. Epub 2006 May 24.

Generation of hybrid hepatocytes by cell fusion from monkey embryoid body cells in the injured mouse liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/16195892

Okamura, K. Asahina, K. Fujimori, H. Ozeki, R. Shimizu-Saito, K. Tanaka, Y. Teramoto, K. Arii, S. Takase, K. Kataoka, M. Soeno, Y. Tateno, C. Yoshizato, K. Teraoka, H.

Histochem Cell Biol. 2006 ;125(3):247-257.

Embryonic dermal condensation and adult dermal papilla induce hair follicles in adult glabrous epidermis through different mechanisms

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16512852&ordinalp=

Inamatsu M, Tochio T, Makabe A, Endo T, Oomizu S, Kobayashi E, Yoshizato K.
Dev Growth Differ. 2006 Feb;48(2):73-86.

Polymorphic CAG Repeats in Androgen Receptor Gene And Their lmplication in Androgenetic Alopecia

Sato A,  Kojima Y, Toyoshima K,  Ishii Y, Yoshizato K

Skin Surgegry. 2006; 15(2): 67-74

Infection of Human Hepatocyte Chimeric Mouse With Genetically Engineered Hepatitis B Virus

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/16250045

Tsuge M, Hiraga N, Takaishi H, Noguchi C, Oga H, Imamura M, Takahashi S, Iwao E, Fujimoto Y, Ochi H, Chayama K, Tateno C, Yoshizato K.

Hepatology. 2005 Nov;42(5):1046-54.

Evaluation of mRNA expression of human drug-metabolizing enzymes and transporters in chimeric mouse with humanized liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/16308282

Nishimura M, Yoshitsugu H, Yokoi T, Tateno C, Kataoka M, Horie T, Yoshizato K, Naito S.

Xenobiotica. 2005 Sep;35(9):877-890.

Efficient in vivo Xenogeneic retroviral vector-mediated gene transduction into human hepatocytes.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/16218778

Kentaro Emoto, Chise Tateno, Hiroshi Hino, Hironobu Amano, Yasuhiro Imaoka, Kinji Asahina, Toshimasa Asahara and Katsutoshi Yoshizato

Hum Gene Ther. 2005 Oct; 16: 1168-1174.