Chimeric mice with humanized liver.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/18248870?ordinalpos=14&itool=EntrezSystem

Katoh M, Tateno C, Yoshizato K, Yokoi T.
Toxicology. 2008 Apr 3;246(1):9-17.

Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/18274954?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Emoto C, Yamato Y, Sato Y, Ohshita H, Katoh M, Tateno C, Yokoi T, Yoshizato K, Iwasaki K.
Xenobiotica. 2008 Mar;38(3):239-48.

Susceptibility of chimeric mice with livers repopulated by serially subcultured human hepatocytes to hepatitis B virus.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/18098326?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Utoh R, Tateno C, Yamasaki C, Hiraga N, Kataoka M, Shimada T, Chayama K, Yoshizato K.
Hepatology. 2008 Feb;47(2):435-46.

キメラマウスにおけるKetoprofenのin vivo代謝試験

橋爪研太、大曽根義安、安達弥長、二宮真一、井上多恵、堀江透

細胞：（特集　ヒト細胞キメラマウスの医学・薬学利用）2008；40（1）：26-29

ヒト肝前駆細胞を用いたキメラマウス

鵜頭理恵、立野知世、吉里勝利

細胞：（特集　ヒト細胞キメラマウスの医学・薬学利用）2008；40（1）：17-21

HBV感染キメラマウスモデル

杉山真也、田中靖人、溝上雅史

細胞：（特集　ヒト細胞キメラマウスの医学・薬学利用）2008；40（1）：13-16

キメラマウスの薬物動態

加藤　美紀、　横井　毅

細胞：（特集　ヒト細胞キメラマウスの医学・薬学利用）2008；40（1）：5-8

ヒト肝細胞キメラマウスの開発とその利用

立野知世

細胞：（特集　ヒト細胞キメラマウスの医学・薬学利用）2008；40（1）：2-4

Correlation between Polymorphic CAG-Repeats in the Androgen-Receptor Gene and Therapeutic Efficiency of Finasteride in Androgenetic Alopecia

 Sato A, Arima Y, Kojima Y, Toyoshima K, Okada T, Ishii Y, Kurata S, Yoshizato K.

Skin Surgegry. 2008; 17(2): 80-86.

ヒト肝細胞キメラマウスの医薬品開発への応用

加国雅和、立野知世

MINOPHAGEN MEDICAL REVIEW 2008; 53: 1-13

Single lymphocyte analysis with a microwell array chip.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/17972305?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Tokimitsu Y, Kishi H, Kondo S, Honda R, Tajiri K, Motoki K, Ozawa T, Kadowaki S, Obata T, Fujiki S, Tateno C, Takaishi H, Chayama K, Yoshizato K, Tamiya E, Sugiyama T, Muraguchi A.
Cytometry A, 2007 Dec;71(12):1003-10.

Human cord blood cells transplanted into chronically damaged liver exhibit similar characteristics to functional hepatocytes

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/17275513

Kakinuma, S. Asahina, K. Okamura, K. Teramoto, K. Tateno, C. Yoshizato, K. Tanaka, Y. Yasumizu, T. Transplant Proc. 2007 Jan-Feb;39(1):240-3.Sakamoto, N.Watanabe, M. Teraoka, H.

Transplant Proc. 2007 Jan-Feb;39(1):240-243.

GH enhances proliferation of human hepatocytes grafted into immunodeficient mice with damaged liver

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17761892&ordinalp=

Masumoto N, Tateno C, Tachibana A, Utoh R, Morikawa Y, Shimada T, Momisako H, Itamoto T, Asahara T,
J Endocrinol. 2007 Sep;194(3):529-37.

Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/17038627

Okada K, Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, Takahashi H, Utsunomiya H, Oda K, Sato K, Watanabe A, Ishii T, Itoh K, Yamamoto M, Yokoi T, Yoshizato K, Sugiyama Y, Suzuki H.

Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1450-1463.

In Vivo Drug Metabolism Model for Human Cytochrome P450 Enzyme Using Chimeric Mice with Humanized Liver

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/17051594

Katoh M, Sawada T, Soeno Y, Nakajima M, Tateno C, Yoshizato K, Yokoi T.

J Pharm Sci. 2007 Feb;96(2):428-437.

Evaluation of human hepatocyte chimeric mice as a model for toxicological investigation using panomic approaches–effect of acetaminophen on the expression profiles of proteins and endogenous metabolites in liver, plasma and urine

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17785938&ordinalp=

Yamamoto T, Tomizawa K, Fujikawa M, Sato Y, Yamada H, Horii I.
J Toxicol Sci. 2007 Aug;32(3):205-15.

Bezafibrate induces multidrug-resistance P-Glycoprotein 3 expression in cultured human hepatocytes and humanized livers of chimeric mice.

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/17539998?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Shoda J, Okada K, Inada Y, Kusama H, Utsunomiya H, Oda K, Yokoi T, Yoshizato K, Suzuki H.
Hepatol Res. 2007 Jul;37(7):548-56.

Humanization of Excretory Pathway in Chimeric Mice with Humanized Liver

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17341479&ordinalp=

Okumura H, Katoh M, Sawada T, Nakajima M, Soeno Y, Yabuuchi H, Ikeda T, Tateno C, Yoshizato K, Yokoi T.
Toxicol Sci. 2007 Jun;97(2):533-8. Epub 2007 Mar 6.

Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C Virus and its susceptibility to interferon

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17466983&ordinalp=

Hiraga N, Imamura M, Tsuge M, Noguchi C, Takahashi S, Iwao E, Fujimoto Y, Abe H, Maekawa T, Ochi H, Tateno C, Yoshizato K, Sakai A, Sakai Y, Honda M, Kaneko S, Wakita T, Chayama K.
FEBS Lett. 2007 May 15;581(10):1983-7. Epub 2007 Apr 20.

Early Dynamics of Hepatitis B Virus in Chimeric Mice Carrying Human Hepatocytes Monoinfected or Coinfected with Genotype G

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17393501&ordinalp=

Sugiyama M, Tanaka Y, Sakamoto T, Maruyama I, Shimada T, Takahashi S, Shirai T, Kato H, Nagao M, Miyakawa Y, Mizokami M.
Hepatology. 2007 Apr;45(4):929-37.