ヒト肝細胞キメラマウスの医薬品開発への応用

加国雅和、立野知世

MINOPHAGEN MEDICAL REVIEW 2008; 53: 1-13

Single lymphocyte analysis with a microwell array chip.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/17972305?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Tokimitsu Y, Kishi H, Kondo S, Honda R, Tajiri K, Motoki K, Ozawa T, Kadowaki S, Obata T, Fujiki S, Tateno C, Takaishi H, Chayama K, Yoshizato K, Tamiya E, Sugiyama T, Muraguchi A.
Cytometry A, 2007 Dec;71(12):1003-10.

Human cord blood cells transplanted into chronically damaged liver exhibit similar characteristics to functional hepatocytes

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/17275513

Kakinuma, S. Asahina, K. Okamura, K. Teramoto, K. Tateno, C. Yoshizato, K. Tanaka, Y. Yasumizu, T. Transplant Proc. 2007 Jan-Feb;39(1):240-3.Sakamoto, N.Watanabe, M. Teraoka, H.

Transplant Proc. 2007 Jan-Feb;39(1):240-243.

GH enhances proliferation of human hepatocytes grafted into immunodeficient mice with damaged liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17761892&ordinalp=

Masumoto N, Tateno C, Tachibana A, Utoh R, Morikawa Y, Shimada T, Momisako H, Itamoto T, Asahara T,
J Endocrinol. 2007 Sep;194(3):529-37.

Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/17038627

Okada K, Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, Takahashi H, Utsunomiya H, Oda K, Sato K, Watanabe A, Ishii T, Itoh K, Yamamoto M, Yokoi T, Yoshizato K, Sugiyama Y, Suzuki H.

Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1450-1463.

In Vivo Drug Metabolism Model for Human Cytochrome P450 Enzyme Using Chimeric Mice with Humanized Liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/17051594

Katoh M, Sawada T, Soeno Y, Nakajima M, Tateno C, Yoshizato K, Yokoi T.

J Pharm Sci. 2007 Feb;96(2):428-437.

Evaluation of human hepatocyte chimeric mice as a model for toxicological investigation using panomic approaches–effect of acetaminophen on the expression profiles of proteins and endogenous metabolites in liver, plasma and urine

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17785938&ordinalp=

Yamamoto T, Tomizawa K, Fujikawa M, Sato Y, Yamada H, Horii I.
J Toxicol Sci. 2007 Aug;32(3):205-15.

Bezafibrate induces multidrug-resistance P-Glycoprotein 3 expression in cultured human hepatocytes and humanized livers of chimeric mice.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/17539998?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Shoda J, Okada K, Inada Y, Kusama H, Utsunomiya H, Oda K, Yokoi T, Yoshizato K, Suzuki H.
Hepatol Res. 2007 Jul;37(7):548-56.

Humanization of Excretory Pathway in Chimeric Mice with Humanized Liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17341479&ordinalp=

Okumura H, Katoh M, Sawada T, Nakajima M, Soeno Y, Yabuuchi H, Ikeda T, Tateno C, Yoshizato K, Yokoi T.
Toxicol Sci. 2007 Jun;97(2):533-8. Epub 2007 Mar 6.

Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C Virus and its susceptibility to interferon

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17466983&ordinalp=

Hiraga N, Imamura M, Tsuge M, Noguchi C, Takahashi S, Iwao E, Fujimoto Y, Abe H, Maekawa T, Ochi H, Tateno C, Yoshizato K, Sakai A, Sakai Y, Honda M, Kaneko S, Wakita T, Chayama K.
FEBS Lett. 2007 May 15;581(10):1983-7. Epub 2007 Apr 20.

Early Dynamics of Hepatitis B Virus in Chimeric Mice Carrying Human Hepatocytes Monoinfected or Coinfected with Genotype G

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17393501&ordinalp=

Sugiyama M, Tanaka Y, Sakamoto T, Maruyama I, Shimada T, Takahashi S, Shirai T, Kato H, Nagao M, Miyakawa Y, Mizokami M.
Hepatology. 2007 Apr;45(4):929-37.

Evaluation of Cyclophilin Inhibitor in Hepatitis C Virus-Infected Chimeric Mice In Vivo

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17393519&ordinalp=

Inoue K, Umehara T, Ruegg UT, Yasui F, Watanabe T, Yasuda H, Dumont JM, Scalfaro P, Yoshiba M, Kohara M.
Hepatology. 2007 Apr;45(4):921-8.

Humanized mice in translational biomedical research.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/17259968?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R

Shultz LD, Ishikawa F, Greiner DL.
Nat Rev Immunol. 2007 Feb;7(2):118-30.

Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17196931&ordinalp=

Nakagawa S, Umehara T, Matsuda C, Kuge S, Sudoh M, Kohara M.
Biochem Biophys Res Commun. 2007 Feb 23;353(4):882-8. Epub 2006 Dec 22.

Application of chimeric mice with humanized liver for predictive adme

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17364883&ordinalp=

Katoh M, Yokoi T.
Drug Metab Rev. 2007;39(1):145-57.

Influence of Hepatitis B Virus Genotypes on the Intra- and Extracellular Expression of Viral DNA and Antigens

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/17006908

Sugiyama M, Tanaka Y, Kato T, Orito E, Ito K, Acharya SK, Gish RG, Kramvis A, Shimada T, Izumi N, Kaito M, Miyakawa Y, Mizokami M.

Hepatology. 2006 Oct;44(4):915-24.

Evaluation of Human CYP1A2 and CYP3A4 mRNA Expression in Hepatocytes from Chimeric Mice with Humanized Liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/17220562

Yoshitsugu H, Nishimura M, Tateno C, Kataoka M, Takahashi E, Soeno Y, Yoshizato K, Yokoi T, Naito S.

Drug Metab Pharmacokinet. 2006;21(6):465-474.

Emergence of a Novel Lamivudine-Resistant Hepatitis B Virus Variant with a Substitution Outside the YMDD Motif

• Pub Med URL https://www.phoenixbio.co.jp/en/rd/thesis/jqunv80000000rv3.html

Yatsuji H, Noguchi C, Hiraga N, Mori N, Tsuge M, Imamura M, Takahashi S, Iwao E, Fujimoto Y, Ochi H, Abe H, Maekawa T, Tateno C, Yoshizato K, Suzuki F, Kumada H, Chayama K.
Antimicrob Agents Chemother. 2006 Nov;50(11):3867-74. Epub 2006 Sep 18.

Characterization of Humanized Liver from Chimeric Mice Using Coumarin as a Human CYP2A6 and Mouse CYP2A5 Probe

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/16946554

Aoki K, Kashiwagura Y, Horie T, Sato H, Tateno C, Ozawa N, Yoshizato K.

Drug Metab Pharmacokinet. 2006 ;21(4):277-285.

Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/16750511

Umehara T, Sudoh M, Yasui F, Matsuda C, Hayashi Y, Chayama K, Kohara M.

Biochem Biophys Res Commun. 2006 Jul 21;346(1):67-73. Epub 2006 May 24.