Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/26352195

Nakada, N. Kawamura, A. Kamimura, H. Sato, K. Kazuki, Y. Kakuni, M. Ohbuchi, M. Kato, K. Tateno, C. Oshimura, M. Usui, T.

Biopharm Drug Dispos. 2015 Sep 9. doi: 10.1002/bdd.1990.

Lack of infectivity of HBV in feces from patients with chronic hepatitis B virus infection, and infection using chimeric mice

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/26289533

Komatsu, H. Inui, A. Murano, T. Tsunoda, T. Sogo, T. Fujisawa, T.

BMC Res Notes. 2015 Aug 20;8:366. doi: 10.1186/s13104-015-1337-z.

Characterization of novel entecavir resistance mutations

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25817219

Hayashi, S. Murakami, S. Omagari, K. Matsui, T. Iio, E. Isogawa, M. Watanabe, T. Karino, Y. Tanaka, Y.

J Hepatol. 2015 Sep;63(3):546-53. doi: 10.1016/j.jhep.2015.03.020. Epub 2015 Mar 25.

Preclinical characterization andin vivoefficacy of GSK8853, a small molecule inhibitor of the Hepatitis C virus NS4B protein

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/26259798

Pouliot, Jeffrey J. Thomson, Michael Xie, Mi Horton, Joseph Johnson, John Krull, David Mathis, Amanda Morikawa, Yoshio Parks, Derek Peterson, Richard, Shimada, Takashi Thomas, Elizabeth Vamathevan, Jessica Van Horn, Stephanie Xiong, Zhiping Hamatake, Robert  Peat, Andrew J.

Antimicrob. Agents Chemother. doi:10.1128/AAC.00813-15

Association between hepatitis B virus and MHC class I polypeptide-related chain A in human hepatocytes derived from human-mouse chimeric mouse liver

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/?term=26212443

Sasaki, R. Kanda, T. Wu, S. Nakamoto, S. Haga, Y. Jiang, X. Nakamura, M.

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Journal: Biochem Biophys Res Commun. 2015 Jul 23. pii: S0006-291X(15)30332-6.

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4′-modified nucleoside analogs: Potent inhibitors active against entecavir-resistant hepatitis B virus

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/?term=26122273

Takamatsu, Y. Tanaka, Y. Kohgo, S. Murakami, S. Singh, K. Das, D. Venzon, D.  J. Amano, M. Kuwata,N. Aoki, M. Delino, N. S. Hayashi, S. Takahashi, S. Sukenaga, Y. Haraguchi, K. Sarafianos, S. G. Maeda, K. Mitsuya, H.

Journal: Hepatology. 2015 Jun 29. doi: 10.1002/hep.27962.

Efficient engraftmentof human iPS cell-derived hepatocyte-like cells in uPA/SCID mice by overexpression of FNK, a Bcl-xmutant gene

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24806294

Nagamoto, Y. Takayama, K. Tashiro, K. Tateno, C. Sakurai, F. Tachibana, M. Kawabata, K. Ikeda, K. Tanaka, Y. Mizuguchi, H.
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Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25979261

Kato, K. Ohbuchi, M. Hamamura, S. Ohshita, H. Kazuki, Y. Oshimura, M. Sato, K. Nakada, N. Kawamura, A. Usui, T. Kamimura, H. Tateno, C.

Drug Metab Dispos. 2015 Aug;43(8):1208-17.

Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti-CD81 monoclonal antibody

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25417967

Ji, C. Liu, Y. Pamulapati, C. Bohini, S. Fertig, G. Schraeml, M. Rubas, W. Brandt, M. Ries, S. Ma, H. Klumpp, K.

Hepatology. 2015 Apr;61(4):1136-44.

Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25869242

Nakada, N. Oda, K.

Xenobiotica. 2015 Apr 14:1-9.

Monoclonal Antibodies against Extracellular Domains of Claudin-1 Block Hepatitis C Virus Infection in a Mouse Model

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25673725

Fukasawa, M. Nagase, S. Shirasago, Y. Iida, M. Yamashita, M. Endo, K. Yagi, K. Suzuki, T. Wakita, T. Hanada, K. Kuniyasu, H. Kondoh, M.

J Virol. 2015 May 1;89(9):4866-79.

Postexposure Prophylactic Effect of Hepatitis B Virus (HBV)-Active Antiretroviral Therapy against HBV Infection

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25512419

Watanabe, T. Hamada-Tsutsumi, S. Yokomaku, Y. Imamura, J. Sugiura, W. Tanaka, Y.

Antimicrob Agents Chemother. 2015 Feb;59(2):1292-8.

Discovering novel direct acting antiviral agents for HBV using in silico screening

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25446116

Murakami, Y. Hayakawa, M. Yano, Y. Tanahashi, T. Enomoto, M. Tamori, A. Kawada, N. Iwadate, M. Umeyama, H.

Biochem Biophys Res Commun. 2015 Jan 2;456(1):20-8.

Novel robust in vitro hepatitis B virus infection model using fresh human hepatocytes isolated from humanized mice

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25791527

Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K, Tateno C

Am J Pathol. 2015 May;185(5):1275-85. doi: 10.1016/j.ajpath.2015.01.028. Epub 2015 Mar 17.

Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25733030

Sanoh, S. Naritomi, Y. Fujimoto, M. Sato, K. Kawamura, A. Horiguchi, A.Sugihara, K. Kotake, Y. Ohshita, H. Tateno, C. Horie, T. Kitamura, S. Ohta, S.

Xenobiotica. 2015 Mar 3:1-10.

The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25557055

Sato, S. Li, K. Kameyama, T. Hayashi, T. Ishida, Y. Murakami, S. Watanabe, T. Iijima, S. Sakurai, Y. Watashi, K. Tsutsumi, S. Sato, Y. Akita, H. Wakita, T. Rice, C. M. Harashima, H. Kohara, M.Tanaka, Y.Takaoka, A.

Immunity. 2015 Jan 20;42(1):123-32.

Validation of cross-genotype neutralization by hepatitis B virus-specific monoclonal antibodies by in vitro and in vivo infection

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25693196

Hamada-Tsutsumi, S. Iio, E. Watanabe, T. Murakami, S. Isogawa, M. Iijima, S. Inoue, T. Matsunami, K. Tajiri, K. Ozawa, T. Kishi, H. Muraguchi, A. Joh, T. Tanaka, Y.

PLoS One. 2015 Feb 18;10(2):e0118062.

Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/25244949

Hara, Y. Yanatori, I. Ikeda, M. Kiyokage, E. Nishina, S. Tomiyama, Y. Toida, K. Kishi, F. Kato, N. Imamura, M. Chayama, K. Hino, K.

Am J Pathol. 2014 Sep 19. pii: S0002-9440(14)00483-0. doi: 10.1016/j.ajpath.2014.07.024.

In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24756133

Watanabe, T. Hatakeyama, H. Matsuda-Yasui, C. Sato, Y. Sudoh, M. Takagi, A. Hirata, Y. Ohtsuki, T. Arai, M. Inoue, K. Harashima, H. Kohara, M.

Sci Rep. 2014 Apr 23;4:4750. doi: 10.1038/srep04750.

Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA

• Pub Med URL http://www.ncbi.nlm.nih.gov/pubmed/24835118

Kohno, T. Tsuge, M. Murakami, E. Hiraga, N. Abe, H. Miki, D. Imamura, M. Ochi,

H. Hayes, C. N. Chayama, K.

J Viral Hepat. 2014 Sep;21(9):e89-97. doi: 10.1111/jvh.12240. Epub 2014 May 16.