FXR Activation by Obeticholic Acid or Non-Steroidal Agonists Induces a Human-Like Lipoprotein Cholesterol Change in Mice with Humanized Chimeric Liver

2018/05/22

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/29559521

Papazyan, R. Liu, X. Liu, J. Dong, B. Plummer, E. M. Lewis, R. D., 2nd Roth, J. D. Young, M. A.

J Lipid Res. 2018 Mar 20. pii: jlr.M081935. doi: 10.1194/jlr.M081935.

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Acute HBV infection in humanized chimeric mice has multiphasic viral kinetics

2018/05/22

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/29572897

Ishida, Y. Chung, T. L. Imamura, M. Hiraga, N. Sen, S. Yokomichi, H. Tateno, C. Canini, L. Perelson, A. S. Uprichard, S. L. Dahari, H. Chayama, K.

Hepatology. 2018 Mar 23. doi: 10.1002/hep.29891.

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Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection

2018/03/12

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/29373739

Rolt, A. Le, D. Hu, Z. Wang, A. Q. Shah, P. Singleton, M. Hughes, E. Dulcey, A. E.He, S. Imamura, M. Uchida, T. Chayama, K. Xu, X. Marugan, J. J. Liang, T. J.

J Infect Dis. 2018 Jan 24. pii: 4823490. doi: 10.1093/infdis/jiy039.

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A natural small molecule inhibitor corilagin blocks HCV replication and modulates oxidative stress to reduce liver damage

2018/03/12

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/29224736

Reddy, B. U. Mullick, R. Kumar, A. Sharma, G. Bag, P. Roy, C. L. Sudha, G. Tandon, H. Dave, P. Shukla, A. Srinivasan, P. Nandhitha, M.Srinivasan, N. Das, S.

Antiviral Res. 2017 Dec 7;150:47-59.

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Investigating the hepatitis B virus life cycle using engineered reporter hepatitis B viruses

2018/03/12

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/29121422

Nishitsuji, H. Harada, K. Ujino, S. Zhang, J. Kohara, M. Sugiyama, M. Mizokami, M. Shimotohno, K.

Cancer Sci. 2018 Jan;109(1):241-249.

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Hepatitis C replication inhibitors that target the viral NS4B protein

2018/03/12

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/23544424

Miller, J. F. Chong, P. Y. Shotwell, J. B. Catalano, J. G. Tai, V. W. Fang, J. Banka, A. L. Roberts, C. D. Youngman, M. Zhang, H. Xiong, Z. Mathis, A. Pouliot, J. J. Hamatake, R. K. Price, D. J. Seal, J. W., 3rd Stroup, L. L. Creech, K. L. Carballo, L. H. Todd, D. Spaltenstein, A. Furst, S. Hong, Z. Peat, A. J.

J Med Chem. 2014 Mar 13;57(5):2107-20

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Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy

2018/03/12

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25760530

Sanoh, S. Tayama, Y. Sugihara, K. Kitamura, S. Ohta, S.

Drug Metab Pharmacokinet. 2015 Feb;30(1):52-63.

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A Novel Orally Available Small Molecule That Inhibits Hepatitis B Virus Expression

2017/12/13

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/29079285

Mueller, H. Wildum, S. Luangsay, S. Walther, J. Lopez, A. Tropberger, P. Ottaviani, G. Lu, W. John Parrott, N. Zhang, J. D. Schmucki, R. Racek, T. Hoflack, J. C. Kueng, E. Point, F. Zhou, X. Steiner, G. Lutgehetmann, M. Rapp, G. Volz, T. Dandri, M. Yang, S. Young, J. A. T. Javanbakht, H.

J Hepatol. 2017 Oct 24. pii: S0168-8278(17)32393-0. doi: 10.1016/j.jhep.2017.10.014.

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Efficacy of NVR 3-778, Alone and in Combination With Pegylated Interferon, vs Entecavir in uPA/SCID Mice With Humanized Livers and HBV Infection

2017/12/13

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/29079518

Klumpp, K. Shimada, T. Allweiss, L. Volz, T. Lutgehetmann, M. Hartman, G. Flores, O. A. Lam, A. M. Dandri, M.

Gastroenterology. 2017 Oct 24. pii: S0016-5085(17)36276-5. doi: 10.1053/j.gastro.2017.10.017.

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Candidate genes responsible for early key events of phenobarbital-promoted mouse hepatocellular tumorigenesis based on differentiation of regulating genes between wild type mice and humanized chimeric mice

2017/12/13

Pub Med URL http://pubs.rsc.org/en/Content/ArticleLanding/2017/TX/C7TX00163K#!divAbstract

Ohara A , Takahashi Y, Kondo M, Okuda Y, Takeda S, Kushida M, Kobayashi K, Sumida K, Yamada T

Toxicol Res. 2017; 6(6): 795-813

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Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin

2017/12/13

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/29142176

Okuda, Y. Kushida, M. Kikumoto, H. Nakamura, Y. Higuchi, H. Kawamura, S. Cohen, S. M. Lake, B. G.Yamada, T.

J Toxicol Sci. 2017;42(6):773-788. doi: 10.2131/jts.42.773.

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Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus

2017/12/13

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28986168

Sato, Y. Matsui, H. Yamamoto, N. Sato, R. Munakata, T. Kohara, M. Harashima, H.

J Control Release. 2017 Oct 3;266:216-225. doi: 10.1016/j.jconrel.2017.09.044.

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Organic anion transporting polypeptides (OATPs)-mediated drug-drug interaction study between rosuvastatin and cyclosporine A in chimeric mice with humanized liver

2017/12/13

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/29051147

Uchida, M. Tajima, Y. Kakuni, M. Kageyama, Y. Okada, T. Sakudara, E. Tateno, C. Hayashi, R.

Drug Metab Dispos. 2017 Oct 19. pii: dmd.117.075994. doi: 10.1124/dmd.117.075994.

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Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver

2017/12/13

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28904294

Sanoh, S. Yamachika, Y. Tamura, Y. Kotake, Y. Yoshizane, Y. Ishida, Y. Tateno, C. Ohta, S.

J Toxicol Sci. 2017;42(5):589-596. doi: 10.2131/jts.42.589.

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Evaluation of antiviral effect of type I, II, and III interferons on direct-acting antiviral-resistant hepatitis C virus

2017/12/13

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/?term=28864074

Hamana, A. Takahashi, Y. Uchida, T. Nishikawa, M. Imamura, M. Chayama, K. Takakura, Y.

Antiviral Res. 2017 Aug 31;146:130-138.

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Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages

2017/08/15

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28665004

Cheng, X. Xia, Y. Serti, E. Block, P. D. Chung, M. Chayama, K. Rehermann, B. Liang, T. J.

Hepatology. 2017 Jun 30. doi: 10.1002/hep.29348.

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Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus

2017/08/15

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28373196

Tsuge, M. Uchida, T. Hiraga, N. Kan, H. Makokha, G. N. Abe-Chayama, H. Miki, D. Imamura, M. Ochi, H. Hayes, C. N. Shimozono, R. Iwamura, T.Narumi, H. Suzuki, T Kainoh, M. Taniguchi, T.

Antimicrob Agents Chemother. 2017 May 24;61(6).

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Critical role of CREBH-mediated induction of TGF-beta2 by HCV infection in fibrogenic responses in hepatic stellate cells

2017/08/15

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28621467

Chida, T. Ito, M. Nakashima, K. Kanegae, Y. Aoshima, T. Takabayashi, S. Kawata, K. Nakagawa, Y. Yamamoto, M. Shimano, H. Matsuura, T. Kobayashi, Y. Suda, T. Suzuki, T.

Hepatology. 2017 Jun 16. doi: 10.1002/hep.29319.

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The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection

2017/08/15

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28095508

Niu, C. Livingston, C. M. Li, L. Beran, R. K. Daffis, S. Ramakrishnan, D. Burdette, D. Peiser, L. Salas, E. Ramos, H. Yu, M. Cheng, G. Strubin, M. Delaney Iv, W. E. Fletcher, S. P.

PLoS One. 2017 Jan 17;12(1):e0169648.

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Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

2017/08/15

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26983541

Decorsiere, A. Mueller, H. van Breugel, P. C. Abdul, F. Gerossier, L. Beran, R. K. Livingston, C. M. Niu, C. Fletcher, S. P. Hantz, O. Strubin, M.

Nature. 2016 Mar 17;531(7594):386-9. doi: 10.1038/nature17170.

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