Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28986168

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J Control Release. 2017 Oct 3;266:216-225. doi: 10.1016/j.jconrel.2017.09.044.

Organic anion transporting polypeptides (OATPs)-mediated drug-drug interaction study between rosuvastatin and cyclosporine A in chimeric mice with humanized liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/29051147

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Drug Metab Dispos. 2017 Oct 19. pii: dmd.117.075994. doi: 10.1124/dmd.117.075994.

Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28904294

Sanoh, S. Yamachika, Y. Tamura, Y. Kotake, Y. Yoshizane, Y. Ishida, Y. Tateno, C. Ohta, S.

J Toxicol Sci. 2017;42(5):589-596. doi: 10.2131/jts.42.589.

Evaluation of antiviral effect of type I, II, and III interferons on direct-acting antiviral-resistant hepatitis C virus

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/?term=28864074

Hamana, A. Takahashi, Y. Uchida, T. Nishikawa, M. Imamura, M. Chayama, K. Takakura, Y.

Antiviral Res. 2017 Aug 31;146:130-138.

Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28665004

Cheng, X. Xia, Y. Serti, E. Block, P. D. Chung, M. Chayama, K. Rehermann, B. Liang, T. J.

Hepatology. 2017 Jun 30. doi: 10.1002/hep.29348.

Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28373196

Tsuge, M. Uchida, T. Hiraga, N. Kan, H. Makokha, G. N. Abe-Chayama, H. Miki, D. Imamura, M. Ochi, H. Hayes, C. N. Shimozono, R. Iwamura, T.Narumi, H. Suzuki, T  Kainoh, M. Taniguchi, T.

Antimicrob Agents Chemother. 2017 May 24;61(6).

Critical role of CREBH-mediated induction of TGF-beta2 by HCV infection in fibrogenic responses in hepatic stellate cells

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28621467

Chida, T. Ito, M. Nakashima, K. Kanegae, Y. Aoshima, T. Takabayashi, S. Kawata, K. Nakagawa, Y. Yamamoto, M. Shimano, H. Matsuura, T. Kobayashi, Y. Suda, T. Suzuki, T.

Hepatology. 2017 Jun 16. doi: 10.1002/hep.29319.

The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28095508

Niu, C. Livingston, C. M. Li, L. Beran, R. K. Daffis, S. Ramakrishnan, D. Burdette, D. Peiser, L. Salas, E. Ramos, H. Yu, M. Cheng, G. Strubin, M. Delaney Iv, W. E. Fletcher, S. P.

PLoS One. 2017 Jan 17;12(1):e0169648.

Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26983541

Decorsiere, A. Mueller, H. van Breugel, P. C. Abdul, F. Gerossier, L. Beran, R. K. Livingston, C. M. Niu, C. Fletcher, S. P. Hantz, O. Strubin, M.

Nature. 2016 Mar 17;531(7594):386-9. doi: 10.1038/nature17170.

Persistent Loss of HBV Markers in Serum without Cellular Immunity by Combination of PEG-IFN Plus ETV Therapy in Humanized Mice

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28696237

Uchida, T. Imamura, M. Hayes, C. N. Hiraga, N. Kan, H. Tsuge, M. Abe-Chayama, H. Zhang, Y. Makokha, G. N. Aikata, H. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

Antimicrob Agents Chemother. 2017 Jul 10. pii: AAC.00725-17. doi: 10.1128/AAC.00725-17

Downregulation of the Complement Cascade In Vitro, in Mice and in Patients with Cardiovascular Disease by the BET Protein Inhibitor Apabetalone (RVX-208)

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28567671

Wasiak, S. Gilham, D. Tsujikawa, L. M. Halliday, C. Calosing, C. Jahagirdar, R. Johansson, J. Sweeney, M. Wong, N. C. Kulikowski, E.

J Cardiovasc Transl Res. 2017 May 31. doi: 10.1007/s12265-017-9755-z.

Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28253324

Miyaki, E. Hiraga, N. Imamura, M. Uchida, T.  Kan, H.  Tsuge, M. Abe-Chayama, H. Hayes, C. N. Makokha, G. N. Serikawa, M. Aikata, H. Ochi, H. Ishida, Y. Tateno, C. Ohdan, H. Chayama, K.

PLoS One. 2017 Mar 2;12(3):e0172412.

Transmission of HBV DNA Mediated by Ceramide-Triggered Extracellular Vesicles

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28275693

Sanada,Takahiro1,*  Hirata, Yuichi1,* Naito, Yutaka 2,  Yamamoto,Naoki1,  Kikkawa, Yoshiaki3, Ishida, Yuji 4,  Yamasaki,Chihiro 4,  Tateno, Chise 4,  Ochiya, Takahiro 2 and  Kohara, Michinori 1

Cell Mol Gastroenterol Hepatol. 2016 Oct 24;3(2):272-283.

Usefulness of humanized cDNA-uPA/SCID mice for the study of hepatitis B virus and hepatitis C virus virology

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28141486

Uchida, T. Imamura, M. Kan, H. Hiraga, N. Hayes, C. N. Tsuge, M. Abe-Chayama, H. Aikata, H. Makokha, G. N. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

J Gen Virol. 2017 Jan 28. doi: 10.1099/jgv.0.000726.

Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/28194636

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Pharm Res. 2017 Feb 13. doi: 10.1007/s11095-017-2116-4.

Propagation of Human Hepatocytes in uPA/SCID Mice: Producing Chimeric Mice with Humanized Liver

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Methods Mol Biol. 2017;1506:91-100. (Book of Hepatocyte Transplantation)

Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/27892765

Miyamoto, M. Iwasaki, S.  Chisaki, I. Nakagawa, S. Amano, N. Hirabayashi, H.

Xenobiotica. 2016 Nov 28:1-54.

Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/27890789

Shimura, S. Watashi, K. Fukano, K. Peel, M. Sluder, A. Kawai, F. Iwamoto, M. Tsukuda, S. Takeuchi, J. S. Miyake, T. Sugiyama, M. Ogasawara, Y. Park, S. Y. Tanaka, Y. Kusuhara, H. Mizokami, M. Sureau, C. Wakita, T.

J Hepatol. 2016 Nov 24. pii: S0168-8278(16)30683-3. doi: 10.1016/j.jhep.2016.11.009.

A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/27863453

Tsukuda, S. Watashi, K. Hojima, T. Isogawa, M. Iwamoto, M. Omagari, K. Suzuki, R. Aizaki, H. Kojima, S. Sugiyama, M. Saito, A. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

Hepatology. 2016 Nov 18. doi: 10.1002/hep.28952.

Lack of exposure in a first-in-man study due to aldehyde oxidase metabolism: Investigated by use of 14C-microdose, humanized mice, monkey pharmacokinetics and in vitro methods

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/27737930

Jensen, K. G. Jacobsen, A. M. Bundgaard, C. Nilausen, D. O. Thale, Z. Chandrasena, G. Jorgensen, M.

Drug Metab Dispos. 2016 Oct 13. pii: dmd.116.072793.