動物モデルを用いた発癌研究

森屋恭爾、三好秀征、小池和彦

新ウイルス性肝炎学 2015 page74-78

ヒト肝細胞キメラマウスを用いたin vivoおよびin vitro HBV感染モデル

石田雄二、横道博、加国雅和、立野知世

新ウイルス性肝炎学 2015 page386-391

HepDART 2015でのPXBマウスおよびPXB-cells関連研究発表のご案内

2015年 12月6日(日)～12月10日(木)にGrand Wailea(Maui, Hawaii)にて開催されましたHepDART 2015

にてPXBマウスおよびPXB-cells関連研究発表がありましたので、ご案内申し上げます。

In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans (In Japanese)(ヒトにおける医薬品の肝毒性及び代謝物のin vtro, in vivo予測評価系の構築に関する研究）

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26521876

Sanoh, S.

Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200.

Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26505121

Yamamoto, N. Sato, Y. Munakata, T. Kakuni, M. Tateno, C. Sanada, T. Hirata, Y. Murakami, S.  Tanaka, Y. Chayama, K. Hatakeyama, H. Hyodo, M. Harashima, H. Kohara, M.

J Hepatol. 2015 Oct 23. pii: S0168-8278(15)00713-8. doi: 10.1016/j.jhep.2015.10.014.

Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir andBMS-788329 combination therapy in human hepatocyte chimeric mice

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26569595

Uchida, T. Hiraga, N. mamura, M. Yoshimi, S. Kan, H. Miyaki, E. Tsuge, M. Abe, H. Hayes, C. N. Aikata, H. Ishida, Y. Tateno, C. Ellis, J. D. Chayama, K.

Virus Res. 2015 Nov 10. pii: S0168-1702(15)30117-9. doi: 10.1016/j.virusres.2015.11.010.

Combination therapies with daclatasvir and asunaprevir on NS3-D168 mutated HCV in human hepatocyte chimeric mice

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26562322

Kan, H. Hiraga, N. Imamura, M. Hayes, C. N. Uchida, T. Miyaki, E. Tsuge, M. Abe, H. Aikata, H. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

Antivir Ther. 2015 Nov 12. doi: 10.3851/IMP3009.

Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26515673

Murakami, E. Tsuge, M. Hiraga,  N.Kan, H. Uchida, T. Masaki, K. Nakahara, T. Ono, A. Miki, D. Kawaoka, T. Abe, H.Imamura, M. Aikata, H. Ochi, H. Hayes, C. N. Akita, T. Tanaka, J. Chayama, K.

J Infect. 2015 Oct 26. pii: S0163-4453(15)00339-4. doi: 10.1016/j.jinf.2015.09.038.

Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26536627

Tateno, C. Kawase, Y. Tobita, Y. Hamamura, S. Ohshita, H. Yokomichi, H. Sanada, H. Kakuni, M. Shiota, A. Kojima, Y. Ishida, Y. Shitara, H. Wada, N. A. Tateishi, H. Sudoh, M. Nagatsuka, S. Jishage, K. Kohara, M.

PLoS One. 2015 Nov 4;10(11):e0142145. doi: 10.1371/journal.pone.0142145. eCollection 2015.

A novel reporter system to monitor early stages of the HBV life cycle

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26310603

Nishitsuji, H. Ujino, S. Shimizu, Y. Harada, K. Zhang, J. Sugiyama, M. Mizokami, M. Shimotohno, K.

Cancer Sci. 2015 Aug 27. doi: 10.1111/cas.12799.

Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26444900

Kamimura, H. Ito, S.

Xenobiotica. 2015 Oct 7:1-13.

Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26352195

Nakada, N. Kawamura, A. Kamimura, H. Sato, K. Kazuki, Y. Kakuni, M. Ohbuchi, M. Kato, K. Tateno, C. Oshimura, M. Usui, T.

Biopharm Drug Dispos. 2015 Sep 9. doi: 10.1002/bdd.1990.

Lack of infectivity of HBV in feces from patients with chronic hepatitis B virus infection, and infection using chimeric mice

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26289533

Komatsu, H. Inui, A. Murano, T. Tsunoda, T. Sogo, T. Fujisawa, T.

BMC Res Notes. 2015 Aug 20;8:366. doi: 10.1186/s13104-015-1337-z.

Characterization of novel entecavir resistance mutations

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25817219

Hayashi, S. Murakami, S. Omagari, K. Matsui, T. Iio, E. Isogawa, M. Watanabe, T. Karino, Y. Tanaka, Y.

J Hepatol. 2015 Sep;63(3):546-53. doi: 10.1016/j.jhep.2015.03.020. Epub 2015 Mar 25.

Preclinical characterization and in vivo efficacy of GSK8853, a small molecule inhibitor of the Hepatitis C virus NS4B protein

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26259798

Pouliot, Jeffrey J. Thomson, Michael Xie, Mi Horton, Joseph Johnson, John Krull, David Mathis, Amanda Morikawa, Yoshio Parks, Derek Peterson, Richard, Shimada, Takashi Thomas, Elizabeth Vamathevan, Jessica Van Horn, Stephanie Xiong, Zhiping Hamatake, Robert  Peat, Andrew J.

Antimicrob. Agents Chemother. doi:10.1128/AAC.00813-15

Association between hepatitis B virus and MHC class I polypeptide-related chain A in human hepatocytes derived from human-mouse chimeric mouse liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/?term=26212443

Sasaki, R. Kanda, T. Wu, S. Nakamoto, S. Haga, Y. Jiang, X. Nakamura, M.

Shirasawa, H. Yokosuka, O.

Journal: Biochem Biophys Res Commun. 2015 Jul 23. pii: S0006-291X(15)30332-6.

doi: 10.1016/j.bbrc.2015.07.102.

4′-modified nucleoside analogs: Potent inhibitors active against entecavir-resistant hepatitis B virus

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/?term=26122273

Takamatsu, Y. Tanaka, Y. Kohgo, S. Murakami, S. Singh, K. Das, D. Venzon, D.  J. Amano, M. Kuwata,N. Aoki, M. Delino, N. S. Hayashi, S. Takahashi, S. Sukenaga, Y. Haraguchi, K. Sarafianos, S. G. Maeda, K. Mitsuya, H.

Journal: Hepatology. 2015 Jun 29. doi: 10.1002/hep.27962.

Efficient engraftmentof human iPS cell-derived hepatocyte-like cells in uPA/SCID mice by overexpression of FNK, a Bcl-xL mutant gene

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24806294

Nagamoto, Y. Takayama, K. Tashiro, K. Tateno, C. Sakurai, F. Tachibana, M. Kawabata, K. Ikeda, K. Tanaka, Y. Mizuguchi, H.
Cell Transplant. 2014 May 6.

Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25979261

Kato, K. Ohbuchi, M. Hamamura, S. Ohshita, H. Kazuki, Y. Oshimura, M. Sato, K. Nakada, N. Kawamura, A. Usui, T. Kamimura, H. Tateno, C.

Drug Metab Dispos. 2015 Aug;43(8):1208-17.

Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti-CD81 monoclonal antibody

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/25417967

Ji, C. Liu, Y. Pamulapati, C. Bohini, S. Fertig, G. Schraeml, M. Rubas, W. Brandt, M. Ries, S. Ma, H. Klumpp, K.

Hepatology. 2015 Apr;61(4):1136-44.