Propagation of Human Hepatocytes in uPA/SCID Mice: Producing Chimeric Mice with Humanized Liver

Ohshita, H. Tateno, C.

Methods Mol Biol. 2017;1506:91-100. (Book of Hepatocyte Transplantation)

Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/27892765

Miyamoto, M. Iwasaki, S.  Chisaki, I. Nakagawa, S. Amano, N. Hirabayashi, H.

Xenobiotica. 2016 Nov 28:1-54.

Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/27890789

Shimura, S. Watashi, K. Fukano, K. Peel, M. Sluder, A. Kawai, F. Iwamoto, M. Tsukuda, S. Takeuchi, J. S. Miyake, T. Sugiyama, M. Ogasawara, Y. Park, S. Y. Tanaka, Y. Kusuhara, H. Mizokami, M. Sureau, C. Wakita, T.

J Hepatol. 2016 Nov 24. pii: S0168-8278(16)30683-3. doi: 10.1016/j.jhep.2016.11.009.

A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/27863453

Tsukuda, S. Watashi, K. Hojima, T. Isogawa, M. Iwamoto, M. Omagari, K. Suzuki, R. Aizaki, H. Kojima, S. Sugiyama, M. Saito, A. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

Hepatology. 2016 Nov 18. doi: 10.1002/hep.28952.

Lack of exposure in a first-in-man study due to aldehyde oxidase metabolism: Investigated by use of 14C-microdose, humanized mice, monkey pharmacokinetics and in vitro methods

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/27737930

Jensen, K. G. Jacobsen, A. M. Bundgaard, C. Nilausen, D. O. Thale, Z. Chandrasena, G. Jorgensen, M.

Drug Metab Dispos. 2016 Oct 13. pii: dmd.116.072793.

Assessing the Therapeutic Potential of Lab-Made Hepatocytes

Rezvani, M. Grimm, A. Willenbring, H.

Hepatology. 2016 Mar 25. doi: 10.1002/hep.28569

Protease inhibitor resistance remains even after mutant strains become undetectable by deep sequencing

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/27651415

Kan, H. Imamura, M. Uchida, T. Hiraga, N. Hayes, C. N. Tsuge, M. Abe, H. Aikata, H. Makokha, G. N. Chowdhury, S. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

J Infect Dis. 2016 Sep 20. pii: jiw437.

Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/27515132

Tanaka, T. Okuyama-Dobashi, K. Murakami, S. Chen, W. Okamoto, T. Ueda, K. Hosoya, T. Matsuura, Y. Ryo, A. Tanaka, Y. Hagiwara, M. Moriishi, K.

Antiviral Res. 2016 Aug 8. pii: S0166-3542(16)30357-6.

Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/27272497

DebRoy, S.  Hiraga, N. Imamura, M. Hayes, C. N. Akamatsu, S. Canini, L. Perelson, A. S. Pohl, R. T. Persiani, S. Uprichard, S. L. Tateno, C. Dahari, H. Chayama, K.

J Viral Hepat. 2016 Jun 8. doi: 10.1111/jvh.12551.

新規核酸アナログ4′-C-cyano-2′-deoxyadenosine, 4′-C-cyano-2′-deoxyguanosineは薬剤耐性B型肝炎ウイルス変異種に対して有効である(短報)

林　佐奈衣、高松悠樹、前田賢次、村上周子，尾曲克已、松居剛志、五十川正記、渡邊網正、狩野吉康、向後悟、濱屋裕明、田中靖人

肝臓 2016; 57(6):299-301

Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/27087417

Toyoda, Y. Takada, T. Suzuki, H.

Sci Rep. 2016 Apr 18;6:24586. doi: 10.1038/srep24586.

Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26943168

Tsuge, M. Hiraga, N. Uchida, T. Kan, H. Miyaki, E. Masaki, K. Ono, A. Nakahara, T. Abe-Chayama, H. Zhang, Y. Naswa, M. G. Kawaoka, T. Miki, D. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Hayes, C. N. Chayama, K.

J Gastroenterol. 2016 Mar 4.

Possible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate Cells

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26731332

Sasaki, R. Kanda, T. Nakamura, M. Nakamoto, S. Haga, Y. Wu, S. Shirasawa, H. Yokosuka, O.

PLoS One. 2016 Jan 5;11(1):e0146314. doi: 10.1371/journal.pone.0146314. eCollection 2016.

A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26378168

Kaneko, M. Watashi, K. Kamisuki, S. Matsunaga, H. Iwamoto, M. Kawai, F. Ohashi, H. Tsukuda, S. Shimura, S. Suzuki, R. Aizaki, H. Sugiyama, M. Park, S. Y. Ito, T. Ohtani, N. Sugawara, F. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

J Virol. 2015 Dec;89(23):11945-53. doi: 10.1128/JVI.01855-15.

動物モデルを用いた発癌研究

森屋恭爾、三好秀征、小池和彦

新ウイルス性肝炎学 2015 page74-78

ヒト肝細胞キメラマウスを用いたin vivoおよびin vitro HBV感染モデル

石田雄二、横道博、加国雅和、立野知世

新ウイルス性肝炎学 2015 page386-391

HepDART 2015でのPXBマウスおよびPXB-cells関連研究発表のご案内

2015年 12月6日(日)～12月10日(木)にGrand Wailea(Maui, Hawaii)にて開催されましたHepDART 2015

にてPXBマウスおよびPXB-cells関連研究発表がありましたので、ご案内申し上げます。

In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans (In Japanese)(ヒトにおける医薬品の肝毒性及び代謝物のin vtro, in vivo予測評価系の構築に関する研究）

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26521876

Sanoh, S.

Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200.

Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26505121

Yamamoto, N. Sato, Y. Munakata, T. Kakuni, M. Tateno, C. Sanada, T. Hirata, Y. Murakami, S.  Tanaka, Y. Chayama, K. Hatakeyama, H. Hyodo, M. Harashima, H. Kohara, M.

J Hepatol. 2015 Oct 23. pii: S0168-8278(15)00713-8. doi: 10.1016/j.jhep.2015.10.014.

Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir andBMS-788329 combination therapy in human hepatocyte chimeric mice

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/26569595

Uchida, T. Hiraga, N. mamura, M. Yoshimi, S. Kan, H. Miyaki, E. Tsuge, M. Abe, H. Hayes, C. N. Aikata, H. Ishida, Y. Tateno, C. Ellis, J. D. Chayama, K.

Virus Res. 2015 Nov 10. pii: S0168-1702(15)30117-9. doi: 10.1016/j.virusres.2015.11.010.