Phoenix Bio

Chimeric mouse with humanized liver, an emerging tool for the drug development「創薬ツールとしてのヒト肝細胞キメラマウス」

2024/01/17

Shimada, T.
Nihon Yakurigaku Zasshi. 2023;158(6):483-489. doi: 10.1254/fpj.23038.

A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor

2024/01/17

Furutani, Y. Hirano, Y. Toguchi, M. Higuchi, S. Qin, X. Y. Yanaka, K. Sato-Shiozaki, Y. Takahashi, N. Sakai, M. Kongpracha, P. Suzuki, T. Dohmae, N. Kukimoto-Niino, M. Shirouzu, M. Nagamori, S. Suzuki, H. Kobayashi, K. Masaki, T. Koyama, H. Sekiba, K. Otsuka, M. Koike, K. Kohara, M. Kojima, S. Kakeya, H. Matsuura, T.
Cell Death Discov. 2023 Dec 22;9(1):467. doi: 10.1038/s41420-023-01755-w.

Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion

2024/01/17

Arakawa, H. Nakazono, Y. Matsuoka, N. Hayashi, M. Shirasaka, Y. Hirao, A. Tamai, I.
Commun Biol. 2023 Aug 22;6(1):866. doi: 10.1038/s42003-023-05216-z.

Hepatocyte-targeted siTAZ therapy lowers liver fibrosis in NASH diet-fed chimeric mice with hepatocyte-humanized livers

Wang, X. Moore, M. P. Shi, H. Miyata, Y. Donnelly, S. K. Radiloff, D. R. Tabas, I.
Mol Ther Methods Clin Dev. 2023 Nov 23;31:101165. doi: 10.1016/j.omtm.2023.101165. eCollection 2023 Dec 14.

SRPKIN-1 as an inhibitor against hepatitis B virus blocking the viral particle formation and the early step of the viral infection

2024/01/17

Li, X. Nakashima, K. Ito, M. Matsuda, M. Chida, T. Sekihara, K. Takahashi, H. Kato, T. Sawasaki, T. Suzuki, T.
Antiviral Res. 2023 Dec;220:105756. doi: 10.1016/j.antiviral.2023.105756. Epub 2023 Nov 20.

A versatile method to profile hepatitis B virus DNA integration

2024/01/17

Fukano, K. Wakae, K. Nao, N. Saito, M. Tsubota, A. Toyoshima, T. Aizaki, H. Iijima, H. Matsudaira, T. Kimura, M. Watashi, K. Sugiura, W. Muramatsu, M.
Hepatol Commun. 2023 Dec 1;7(12):e0328. doi: 10.1097/HC9.0000000000000328. eCollection 2023 Dec 1.

Quantitative prediction of CYP3A-mediated drug-drug interactions by correctly estimating fraction metabolized using human liver chimeric mice

2024/01/17

Miyake, T. Mochizuki, T. Nakagawa, T. Nakamura, M. Emoto, C. Komiyama, N. Hirabayashi, M. Tsuruta, S. Shimojo, T. Terao, K. Tachibana, T.
Br J Pharmacol. 2023 Oct 23. doi: 10.1111/bph.16270.

Development and characterization of secondary standards for nucleic acid amplification technology (NAAT) assays for detection of hepatitis E virus

2023/10/18

Fares-Gusmao, R. Jiang, Z. Subramaniam, S. Visser, B. J. Scott, A. Ishida, Y. Saito, T. Baylis, S. A. McGivern, D. R. H. E. V. Standard Calibration Study Group
J Clin Virol. 2022 Dec;157:105325. doi: 10.1016/j.jcv.2022.105325.

Functional involvement of endothelial lipase in hepatitis B virus infection

2023/10/18

Shirasaki, T. Murai, K. Ishida, A. Kuroki, K. Kawaguchi, K. Wang, Y. Yamanaka, S. Yasukawa, R. Kawasaki, N. Li, Y. Y. Shimakami, T. Sumiyadorj, A. Nio, K. Sugimoto, S. Orita, N. Takayama, H. Okada, H. Thi Bich, P. D. Iwabuchi, S. Hashimoto, S. Ide, M. Tabata, N. Ito, S. Matsushima, K. Yanagawa, H. Yamashita, T. Kaneko, S. Honda, M.
Hepatol Commun. 2023 Aug 31;7(9):e0206.

Function of hepatocyte spheroids in bioactive microcapsules is enhanced by endogenous and exogenous hepatocyte growth factor

2023/10/18

Gwon, K. Choi, D. de Hoyos-Vega, J. M. Baskaran, H. Gonzalez-Suarez, A. M. Lee, S. Hong, H. J. Nguyen, K. M.n Dharmesh, E. Sugahara, G. Ishida, Y. Saito, T. Stybayeva, G. Revzin, A.
Bioact Mater. 2023 May 24;28:183-195. doi: 10.1016/j.bioactmat.2023.05.009.

Guiding Hepatic Differentiation of Pluripotent Stem Cells Using 3D Microfluidic Co-Cultures with Human Hepatocytes

2023/10/18

Fattahi, P. de Hoyos-Vega, J. M. Choi, J. H. Duffy, C. D. Gonzalez-Suarez, A. M. Ishida, Y. Nguyen, K. M. Gwon, K. Peterson, Q. P. Saito, T. Stybayeva, G. Revzin, A.
Cells. 2023 Aug 1;12(15):1982. doi: 10.3390/cells12151982.

Efficient gene transduction in pigs and macaques with the engineered AAV vector AAV.GT5 for hemophilia B gene therapy

2023/10/18

Kashiwakura, Y. Endo, K. Ugajin, A. Kikuchi, T. Hishikawa, S. Nakamura, H. Katakai, Y. Baatartsogt, N. Hiramoto, T. Hayakawa, M. Kamoshita, N. Yamazaki, S. Kume, A. Mori, H. Sata, N. Sakata, Y. Muramatsu, S. I. Ohmori, T.
Mol Ther Methods Clin Dev. 2023 Aug 22;30:502-514. doi: 10.1016/j.omtm.2023.08.016.

Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics

2023/10/18

Hailegiorgis, A. Ishida, Y. Collier, N. Imamura, M. Shi, Z. Reinharz, V. Tsuge, M. Barash, D. Hiraga, N. Yokomichi, H. Tateno, C. Ozik, J. Uprichard, S. L. Chayama, K. Dahari, H.
PLoS Comput Biol. 2023 Aug 3;19(8):e1011309. doi: 10.1371/journal.pcbi.1011309.

Evaluation of RNAi Therapeutics VIR-2218 and ALN-HBV for Chronic Hepatitis B: Results From Randomized Clinical Trials

2023/08/15

Gane, E. Lim, Y. S. Kim, J. B. Jadhav, V. Shen, L. Bakardjiev, A. I. Huang, S. A. Cathcart, A. L. Lempp, F. A. Janas, M. M. Cloutier, D. J. Kaittanis, C. Sepp-Lorenzino, L, Hinkle, G. Taubel, J. Haslett, P. Milstein, S. Anglero-Rodriguez, Y. I. Hebner, C. M. Pang, P. S. Yuen, M. F.
J Hepatol. 2023 Jun 6:S0168-8278(23)00352-5. doi: 10.1016/j.jhep.2023.05.023.

Super-Resolution Microscopy Analysis of Hepatitis B Viral cccDNA and Host Factors

2023/08/15

Doan, P. T. B. Nio, K. Shimakami, T. Kuroki, K. Li, Y. Y. Sugimoto, S. Takayama, H. Okada, H. Kaneko, S. Honda, M. Yamashita, T.
Viruses. 2023 May 16;15(5):1178. doi: 10.3390/v15051178.

Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response

2023/08/15

Chida, T. Ishida, Y. Morioka, S. Sugahara, G. Han, C. Lam, B. Yamasaki, C. Sugahara, R. Li, M. Tanaka, Y. Liang, T. J. Tateno, C. Saito, T.
JCI Insight. 2023 May 8;8(9):e162404. doi: 10.1172/jci.insight.162404.

Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells

2023/08/15

Aoki-Utsubo, C. Indrasetiawan, P. Fukano, K. Muramatsu, M. Artanti, N. Hanafi, M. Hotta, H. Kameoka, M.
Microbiol Immunol. 2023 Mar 16. doi: 10.1111/1348-0421.13064.

Characterization of a Novel Capsid Assembly Modulator for the Treatment of Chronic Hepatitis B Virus Infection

2023/08/15

Burdette, D. Hyrina, A. Song, Z. Beran, R. K. Cheung, T. Gilmore, S. Kobayashi, T. Li, L. Liu, Y. Niedziela-Majka, A. Medley, J. Mehra, U. Morganelli, P. Novikov, N. Niu, C. Tam, D. Tang, J. Wang, J. Yue, Q. Fletcher, S. P. Holdorf, M. M. Delaney, W. E. th Feierbach, B. Lazerwith, S.
Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0134822. doi: 10.1128/aac.01348-22.

Downregulation of SOCS1 increases interferon-induced ISGylation during differentiation of induced-pluripotent stem cells to hepatocytes

2023/04/13

Edwards, J. S. Delabat, S. A. Badilla, A. D. DiCaprio, R. C. Hyun, J. Burgess, R. A. Silva, T. Dykxhoorn, D. M. Chen, S. X. Wang, L. Ishida, Y. Saito, T. Thomas, E.
JHEP Rep. 2022 Sep 23;4(12):100592. doi: 10.1016/j.jhepr.2022.100592. eCollection 2022 Dec.

The Gut-Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology

2023/04/13

Guo, Y. Chen, X. Gong, P.Li, G. Yao, W. Yang, W.
Int J Mol Sci. 2023 Feb 17;24(4):4089. doi: 10.3390/ijms24044089.