Development of an effective single-chain variable fragment recognizing a novel epitope in the hepatitis C virus E2 protein that restricts virus entry into hepatocytes

2024/05/21

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38683226

Das, S. Behera, P. Shewale, D. J. Bodele, J. Das, S. Karande, A. A.
Arch Virol. 2024 Apr 29;169(5):112. doi: 10.1007/s00705-024-06024-4.

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A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA

2024/05/21

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38315437

Watanabe, T. Hayashi, S. Zhaoyu, Y. Inada, H. Nagaoka, K. Tateyama, M. Tanaka, Y.
J Gastroenterol. 2024 Apr;59(4):315-328. doi: 10.1007/s00535-023-02070-y. Epub 2024 Feb 5.

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Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism

2024/05/21

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38384383

Kurniawan, D. A. Leo, S. Inamatsu, M. Funaoka, S. Aihara, T. Aiko, M. Rei, I. Sakura, T. Arakawa, H. Kato, Y. Matsugi, T. Esashika, K. Shiraki, N. Kume, S. Shinha, K. Kimura, H. Nishikawa, M. Sakai, Y.
PNAS Nexus. 2024 Feb 9;3(2):pgae070. doi: 10.1093/pnasnexus/pgae070. eCollection 2024 Feb.

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Multi-omics analysis of a fatty liver model using human hepatocyte chimeric mice

2024/05/21

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38336825

Ichikawa, A. Miki, D. Hayes, C. N. Teraoka, Y. Nakahara, H. Tateno, C. Ishida, Y. Chayama, K. Oka, S.
Sci Rep. 2024 Feb 9;14(1):3362. doi: 10.1038/s41598-024-53890-8.

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Nucleos(t)ide analogs for hepatitis B virus infection differentially regulate the growth factor signaling in hepatocytes

2024/05/21

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38180972

Shimizu, R. Murai, K. Tanaka, K. Sato, Y. Takeda, N. Nakasyo, S. Shirasaki, T. Kawaguchi, K. Shimakami, T. Nio, K. Nakaya, Y. Kagiwada, H. Horimoto, K. Mizokami, M. Kaneko, S. Murata, K. Yamashita, T. Honda, M.
Hepatol Commun. 2024 Jan 5;8(1):e0351. doi: 10.1097/HC9.0000000000000351. eCollection 2024 Jan 1.

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Hepatitis B virus evades the immune system by suppressing the NF-kappaB signaling pathway with DENND2A

2024/05/21

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38240571

Ide, M. Tabata, N. Yonemura, Y. Murai, K. Wang, Y. Ishida, A. Honda, M. Kaneko, S. Ito, S. Yanagawa, H.
Microbiol Spectr. 2024 Jan 19:e0378523. doi: 10.1128/spectrum.03785-23.

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Chimeric mouse with humanized liver, an emerging tool for the drug development「創薬ツールとしてのヒト肝細胞キメラマウス」

2024/01/17

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/37914329

Shimada, T.
Nihon Yakurigaku Zasshi. 2023;158(6):483-489. doi: 10.1254/fpj.23038.

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A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor

2024/01/17

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38135680

Furutani, Y. Hirano, Y. Toguchi, M. Higuchi, S. Qin, X. Y. Yanaka, K. Sato-Shiozaki, Y. Takahashi, N. Sakai, M. Kongpracha, P. Suzuki, T. Dohmae, N. Kukimoto-Niino, M. Shirouzu, M. Nagamori, S. Suzuki, H. Kobayashi, K. Masaki, T. Koyama, H. Sekiba, K. Otsuka, M. Koike, K. Kohara, M. Kojima, S. Kakeya, H. Matsuura, T.
Cell Death Discov. 2023 Dec 22;9(1):467. doi: 10.1038/s41420-023-01755-w.

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Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion

2024/01/17

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/37608051

Arakawa, H. Nakazono, Y. Matsuoka, N. Hayashi, M. Shirasaka, Y. Hirao, A. Tamai, I.
Commun Biol. 2023 Aug 22;6(1):866. doi: 10.1038/s42003-023-05216-z.

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Hepatocyte-targeted siTAZ therapy lowers liver fibrosis in NASH diet-fed chimeric mice with hepatocyte-humanized livers

2024/01/17

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38144682

Wang, X. Moore, M. P. Shi, H. Miyata, Y. Donnelly, S. K. Radiloff, D. R. Tabas, I.
Mol Ther Methods Clin Dev. 2023 Nov 23;31:101165. doi: 10.1016/j.omtm.2023.101165. eCollection 2023 Dec 14.

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SRPKIN-1 as an inhibitor against hepatitis B virus blocking the viral particle formation and the early step of the viral infection

2024/01/17

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/37992764

Li, X. Nakashima, K. Ito, M. Matsuda, M. Chida, T. Sekihara, K. Takahashi, H. Kato, T. Sawasaki, T. Suzuki, T.
Antiviral Res. 2023 Dec;220:105756. doi: 10.1016/j.antiviral.2023.105756. Epub 2023 Nov 20.

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A versatile method to profile hepatitis B virus DNA integration

2024/01/17

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38051537

Fukano, K. Wakae, K. Nao, N. Saito, M. Tsubota, A. Toyoshima, T. Aizaki, H. Iijima, H. Matsudaira, T. Kimura, M. Watashi, K. Sugiura, W. Muramatsu, M.
Hepatol Commun. 2023 Dec 1;7(12):e0328. doi: 10.1097/HC9.0000000000000328. eCollection 2023 Dec 1.

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Quantitative prediction of CYP3A-mediated drug-drug interactions by correctly estimating fraction metabolized using human liver chimeric mice

2024/01/17

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/37872109

Miyake, T. Mochizuki, T. Nakagawa, T. Nakamura, M. Emoto, C. Komiyama, N. Hirabayashi, M. Tsuruta, S. Shimojo, T. Terao, K. Tachibana, T.
Br J Pharmacol. 2023 Oct 23. doi: 10.1111/bph.16270.

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Development and characterization of secondary standards for nucleic acid amplification technology (NAAT) assays for detection of hepatitis E virus

2023/10/18

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/36395548

Fares-Gusmao, R. Jiang, Z. Subramaniam, S. Visser, B. J. Scott, A. Ishida, Y. Saito, T. Baylis, S. A. McGivern, D. R. H. E. V. Standard Calibration Study Group
J Clin Virol. 2022 Dec;157:105325. doi: 10.1016/j.jcv.2022.105325.

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Functional involvement of endothelial lipase in hepatitis B virus infection

2023/10/18

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/37655967

Shirasaki, T. Murai, K. Ishida, A. Kuroki, K. Kawaguchi, K. Wang, Y. Yamanaka, S. Yasukawa, R. Kawasaki, N. Li, Y. Y. Shimakami, T. Sumiyadorj, A. Nio, K. Sugimoto, S. Orita, N. Takayama, H. Okada, H. Thi Bich, P. D. Iwabuchi, S. Hashimoto, S. Ide, M. Tabata, N. Ito, S. Matsushima, K. Yanagawa, H. Yamashita, T. Kaneko, S. Honda, M.
Hepatol Commun. 2023 Aug 31;7(9):e0206.

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Function of hepatocyte spheroids in bioactive microcapsules is enhanced by endogenous and exogenous hepatocyte growth factor

2023/10/18

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/37266448

Gwon, K. Choi, D. de Hoyos-Vega, J. M. Baskaran, H. Gonzalez-Suarez, A. M. Lee, S. Hong, H. J. Nguyen, K. M.n Dharmesh, E. Sugahara, G. Ishida, Y. Saito, T. Stybayeva, G. Revzin, A.
Bioact Mater. 2023 May 24;28:183-195. doi: 10.1016/j.bioactmat.2023.05.009.

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Guiding Hepatic Differentiation of Pluripotent Stem Cells Using 3D Microfluidic Co-Cultures with Human Hepatocytes

2023/10/18

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/37566061

Fattahi, P. de Hoyos-Vega, J. M. Choi, J. H. Duffy, C. D. Gonzalez-Suarez, A. M. Ishida, Y. Nguyen, K. M. Gwon, K. Peterson, Q. P. Saito, T. Stybayeva, G. Revzin, A.
Cells. 2023 Aug 1;12(15):1982. doi: 10.3390/cells12151982.

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Efficient gene transduction in pigs and macaques with the engineered AAV vector AAV.GT5 for hemophilia B gene therapy

2023/10/18

Pub Med URL https://doi.org/10.1016/j.omtm.2023.08.016

Kashiwakura, Y. Endo, K. Ugajin, A. Kikuchi, T. Hishikawa, S. Nakamura, H. Katakai, Y. Baatartsogt, N. Hiramoto, T. Hayakawa, M. Kamoshita, N. Yamazaki, S. Kume, A. Mori, H. Sata, N. Sakata, Y. Muramatsu, S. I. Ohmori, T.
Mol Ther Methods Clin Dev. 2023 Aug 22;30:502-514. doi: 10.1016/j.omtm.2023.08.016.

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Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics

2023/10/18

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/37535676

Hailegiorgis, A. Ishida, Y. Collier, N. Imamura, M. Shi, Z. Reinharz, V. Tsuge, M. Barash, D. Hiraga, N. Yokomichi, H. Tateno, C. Ozik, J. Uprichard, S. L. Chayama, K. Dahari, H.
PLoS Comput Biol. 2023 Aug 3;19(8):e1011309. doi: 10.1371/journal.pcbi.1011309.

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Evaluation of RNAi Therapeutics VIR-2218 and ALN-HBV for Chronic Hepatitis B: Results From Randomized Clinical Trials

2023/08/15

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/37290591

Gane, E. Lim, Y. S. Kim, J. B. Jadhav, V. Shen, L. Bakardjiev, A. I. Huang, S. A. Cathcart, A. L. Lempp, F. A. Janas, M. M. Cloutier, D. J. Kaittanis, C. Sepp-Lorenzino, L, Hinkle, G. Taubel, J. Haslett, P. Milstein, S. Anglero-Rodriguez, Y. I. Hebner, C. M. Pang, P. S. Yuen, M. F.
J Hepatol. 2023 Jun 6:S0168-8278(23)00352-5. doi: 10.1016/j.jhep.2023.05.023.

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