Phoenix Bio

Identification of glycogen synthase kinase 3alpha/beta as a host factor required for HBV transcription using high-throughput screening

2025/05/08

Nishitsuji, H. Naito, Y. Murakami, Y. Sugiyama, M. Mizokami, M. Shoji, I. Murata, T. Shimotohno, K.
Hepatology. 2025 Jan 23. doi: 10.1097/HEP.0000000000001239.

Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems

2025/05/08

Nosaka, T. Naito, T. Akazawa, Y. Takahashi, K. Matsuda, H. Ohtani, M. Nishizawa, T. Okamoto, H. Nakamoto, Y.
PLoS One. 2025 Mar 6;20(3):e0314581. doi: 10.1371/journal.pone.0314581.

Quantitative prediction of drug disposition for uridine diphosphate-glucuronosyltransferase substrates using humanized mice

2025/05/08

Miyake, T. Fujita, Y. Hirabayashi, M. Komiyama, N. Morita, K. Tachibana, T. Terao, K.
Drug Metab Dispos. 2025 Feb 10;53(4):100050. doi: 10.1016/j.dmd.2025.100050.

Development of human growth hormone-treated chimeric mice with humanized livers for an evaluation model of drug-induced fatty liver disease

2025/05/08

Morioka, S. Sanoh, S. Ishida, Y. Furukawa, S. Ogawa, Y.Kotake, Y. Tateno, C.
Arch Toxicol. 2025 Feb 21. doi: 10.1007/s00204-025-03986-5.

Investigation of Biotransformation Pathways in a Chimeric Mouse with a Humanized Liver

2025/05/08

Karlsson, I. B. Ekdahl, A. Etchingham-Coll, H. Li, X. Q. Ericsson, C. Ahlqvist, M. Samuelsson, K.
Int J Mol Sci. 2025 Jan 28;26(3):1141. doi: 10.3390/ijms26031141

Endothelial lipase-binding peptides similar to netrin-1 inhibit hepatitis B virus infection

2025/05/08

Ide, M. Tabata, N. Murai, K. Yonemura, Y. Wang, Y. Ishida, A. Shirasaki, T. Kaneko, S. Ito, S. Honda, M. Yanagawa, H.
FEBS Lett. 2025 Jan 25. doi: 10.1002/1873-3468.15101.

Induction of phospholipase A2 group 4C by HCV infection regulates lipid droplet formation

2025/05/08

Ito, M. Liu, J. Fukasawa, M. Tsutsumi, K. Kanegae, Y. Setou, M. Kohara, M. Suzuki, T.
JHEP Rep. 2024 Sep 30;7(1):101225. doi: 10.1016/j.jhepr.2024.101225.

Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene

2025/05/08

Zhang, M. Mouzannar, K. Zhang, Z. Teraoka, Y. Piotrowski, J. Ishida, Y. Tateno-Mukaidani, C. Saito, T.Abe-Chayama, H. Chayama, K.Liang, T. J.
PLoS Pathog. 2025 Jan 9;21(1):e1012803. doi: 10.1371/journal.ppat.1012803.

Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies

2025/05/08

Shi, Z. Mhlanga, A. Ishida, Y. Josephson, A. Collier, N. T. Abe-Chayama, H. Tateno-Mukaidani, C. Cotler, S. J. Ozik, J. Major, M. Feld, J. J. Chayama, K. Dahari, H.
Sci Rep. 2024 Dec 30;14(1):31826. doi: 10.1038/s41598-024-83104-0.

Alteration of Gene Expression After Entecavir and Pegylated Interferon Therapy in HBV-Infected Chimeric Mouse Liver

2025/05/08

Bao, H. Murakami, S. Tsuge, M. Uchida, T. Uchikawa, S. Fujino, H. Ono, A. Murakami, E. Kawaoka, T. Miki, D. Hayes, C. N. Oka, S.
Viruses. 2024 Nov 6;16(11):1743. doi: 10.3390/v16111743.

Modelling of hepatitis B virus kinetics and accumulation of cccDNA in primary human hepatocytes

2025/05/08

Louis Shekhtman, Yuji Ishida, Masataka Tsuge, Vladimir Reinharz, Mikaru Yamao, Masaki Takahashi, Chise Tateno, Susan L. Uprichard, Harel Dahari, Kazuaki Chayama
JHEP Reports https://doi.org/10.1016/j.jhepr.2024.101311.

An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection

2024/11/06

Mukherji, A. Jühling, F. Simanjuntak, Y. Crouchet, E. Del Zompo, F. Teraoka, Y. Haller, A. Baltzinger, P. Paritala, S. Rasha, F. Fujiwara, N. Gadenne, C. Slovic, N. Oudot, M. A. Durand, S. C.
Nat Commun. 2024 Aug 29;15(1):7486. doi: 10.1038/s41467-024-51698-8.

Plasma and urinary CP I and CP III concentrations in chimeric mice with human hepatocytes after rifampicin administration

2024/11/06

Shishido, Y. Yoshida, T. Oshida, K. Uchida, M.
Pharmacol Res Perspect. 2024 Oct;12(5):e70017. doi: 10.1002/prp2.70017.

Infectivity of Hepatitis B Virus Surface Antigen-Positive Plasma With Undetectable HBV-DNA: Can HBsAg Screening Be Discontinued in Egyptian Blood Donors?

2024/11/06

El Ekiaby, M. Tanaka, J. van Drimmelen, H. Allain, J. P. Lelie, N.
J Viral Hepat. 2024 Aug 10. doi: 10.1111/jvh.13990.

Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice

2024/11/06

Duehren, S. Uchida, T. Tsuge, M. Hiraga, N. Uprichard, S. L. Etzion, O. Glenn, J. Koh, C. Heller, T. Cotler, S. J. Oka, S. Chayama, K. Dahari, H.
Virus Res. 2024 Aug 26;349:199451. doi: 10.1016/j.virusres.2024.199451.

The Evaluation of Lipid Analysis for PXB-Cells LA as a Human Non-Alcoholic Fatty Liver Disease Model

2024/11/06

Takahashi, Masaki Tomatsu, Sayaka Inamatsu, Mutsumi, Yoshikawa, Nami, Hata, Keishi, Kakuni, Masakazu
BPB Reports (2024) 7(4):147-156

Lipid nanoparticle-encapsulated DOCK11-siRNA efficiently reduces hepatitis B virus cccDNA level in infected mice

2024/11/06

Okada, H. Sakamoto, T. Nio, K. Li, Y. Kuroki, K. Sugimoto, S. Shimakami, T. Doi, N. Honda, M. Seiki, M. Kaneko, S. Yamashita, T.
Mol Ther Methods Clin Dev. 2024 Jun 24;32(3):101289. doi: 10.1016/j.omtm.2024.101289.

Human Hepatocytes Can Give Rise to Intrahepatic Cholangiocarcinomas

2024/11/06

Hsu, Bernadette Y. Driscoll, Julia. Tateno, Chise. Mattis, Aras N. Kelley, Robin K. Willenbring, Holger
Gastroenterology. 2024 Oct;167(5):1029-1032.e7. doi: 10.1053/j.gastro.2024.05.033.

Utility of Chimeric Mice with Humanized Livers for Predicting Hepatic Organic Anion – Transporting Polypeptide 1B (OATP1B) – Mediated Clinical Drug-Drug Interactions

2024/11/06

Feng, B. Liang, G. Zetterberg, C. Li, S. Huang, H. Williams, J.Gao, H. Morikawa, Y. Kumar, S.
Drug Metab Dispos. 2024 Aug 5:DMD-AR-2024-001792. doi: 10.1124/dmd.124.001792.

Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein

2024/11/06

Kornyeyev, D. Song, Z. Eng, S. Soulette, C. Ramirez, R. Tang, J. Yue, Q. Subramanian, R. Zaboli, S. Moon, C. Tam, J. Brodbeck, J. Aggarwal, A. Diehl, L. Fletcher, S. P. Hyrina, A. Holdorf, M. M. Burdette, D.
Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0042024. doi: 10.1128/aac.00420-24.