An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection

• Pub Med URL https://pubmed.ncbi.nlm.nih.gov/39209804/

Mukherji, A. Jühling, F. Simanjuntak, Y. Crouchet, E. Del Zompo, F. Teraoka, Y. Haller, A. Baltzinger, P. Paritala, S. Rasha, F. Fujiwara, N. Gadenne, C. Slovic, N. Oudot, M. A. Durand, S. C.
Nat Commun. 2024 Aug 29;15(1):7486. doi: 10.1038/s41467-024-51698-8.

Plasma and urinary CP I and CP III concentrations in chimeric mice with human hepatocytes after rifampicin administration

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/39312270

Shishido, Y. Yoshida, T. Oshida, K. Uchida, M.
Pharmacol Res Perspect. 2024 Oct;12(5):e70017. doi: 10.1002/prp2.70017.

Infectivity of Hepatitis B Virus Surface Antigen-Positive Plasma With Undetectable HBV-DNA: Can HBsAg Screening Be Discontinued in Egyptian Blood Donors?

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/39126258

El Ekiaby, M. Tanaka, J. van Drimmelen, H. Allain, J. P. Lelie, N.
J Viral Hepat. 2024 Aug 10. doi: 10.1111/jvh.13990.

Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/39168375

Duehren, S. Uchida, T. Tsuge, M. Hiraga, N. Uprichard, S. L. Etzion, O. Glenn, J. Koh, C. Heller, T. Cotler, S. J. Oka, S. Chayama, K. Dahari, H.
Virus Res. 2024 Aug 26;349:199451. doi: 10.1016/j.virusres.2024.199451.

The Evaluation of Lipid Analysis for PXB-Cells LA as a Human Non-Alcoholic Fatty Liver Disease Model

• Pub Med URL https://www.jstage.jst.go.jp/article/bpbreports/7/4/7_147/_article

Takahashi, Masaki Tomatsu, Sayaka Inamatsu, Mutsumi, Yoshikawa, Nami, Hata, Keishi, Kakuni, Masakazu
BPB Reports (2024) 7(4):147-156

Lipid nanoparticle-encapsulated DOCK11-siRNA efficiently reduces hepatitis B virus cccDNA level in infected mice

• Pub Med URL https://pubmed.ncbi.nlm.nih.gov/39109217/

Okada, H. Sakamoto, T. Nio, K. Li, Y. Kuroki, K. Sugimoto, S. Shimakami, T. Doi, N. Honda, M. Seiki, M. Kaneko, S. Yamashita, T.
Mol Ther Methods Clin Dev. 2024 Jun 24;32(3):101289. doi: 10.1016/j.omtm.2024.101289.

Human Hepatocytes Can Give Rise to Intrahepatic Cholangiocarcinomas

• Pub Med URL https://pubmed.ncbi.nlm.nih.gov/38866344/

Hsu, Bernadette Y. Driscoll, Julia. Tateno, Chise. Mattis, Aras N. Kelley, Robin K. Willenbring, Holger
Gastroenterology. 2024 Oct;167(5):1029-1032.e7. doi: 10.1053/j.gastro.2024.05.033.

Utility of Chimeric Mice with Humanized Livers for Predicting Hepatic Organic Anion – Transporting Polypeptide 1B (OATP1B) – Mediated Clinical Drug-Drug Interactions

• Pub Med URL https://pubmed.ncbi.nlm.nih.gov/39103225/

Feng, B. Liang, G. Zetterberg, C. Li, S. Huang, H. Williams, J.Gao, H. Morikawa, Y. Kumar, S.
Drug Metab Dispos. 2024 Aug 5:DMD-AR-2024-001792. doi: 10.1124/dmd.124.001792.

Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein

• Pub Med URL https://pubmed.ncbi.nlm.nih.gov/38780261/

Kornyeyev, D. Song, Z. Eng, S. Soulette, C. Ramirez, R. Tang, J. Yue, Q. Subramanian, R. Zaboli, S. Moon, C. Tam, J. Brodbeck, J. Aggarwal, A. Diehl, L. Fletcher, S. P. Hyrina, A. Holdorf, M. M. Burdette, D.
Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0042024. doi: 10.1128/aac.00420-24.

Antiviral effect of peptoids on hepatitis B virus infection in cell culture

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38272318

Murayama, A. Igarashi, H. Yamada, N. Aly, H. H. Molchanova, N. Lin, J. S. Nishitsuji, H. Shimotohno, K. Muramatsu, M. Barron, A. E. Kato, T.
Antiviral Res. 2024 Mar;223:105821. doi: 10.1016/j.antiviral.2024.105821.

The mitochondrial TSPO ligand Atriol mitigates metabolic-associated steatohepatitis by downregulating CXCL1

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38871077

Li, Y. Chen, L.b. Sottas, C. Raul, M. C. Patel, N. D. Bijja, J. R. Ahmed, S. K. Kapelanski-Lamoureux, A. Lazaris, A. Metrakos, P. Zambidis, A. Chopra, S. Li, M. Sugahara, G. Saito, T.
Metabolism. 2024 Jun 11:155942. doi: 10.1016/j.metabol.2024.155942

An allosteric inhibitor of sirtuin 2 blocks hepatitis B virus covalently closed circular DNA establishment and its transcriptional activity

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38641024

Tang, L. Remiszewski, S. Snedeker, A. Chiang, L. W. Shenk, T.
Antiviral Res. 2024 Jun;226:105888. doi: 10.1016/j.antiviral.2024.105888.

A Novel Approach to Orthotopic Hepatocyte Transplantation Engineered With Liver Hydrogel for Fibrotic Livers, Enhancing Cell-Cell Interaction and Angiogenesis

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38770981

Udagawa, D. Nagata, S. Yagi, H. Nishi, K. Morisaku, T. Adachi, S. Nakano, Y. Tanaka, M. Hori, S. Hasegawa, Y.. Abe, Y. Kitago, M. Kitagawa, Y.
FEBS Lett. 2024 Jun;598(11):1354-1365. doi: 10.1002/1873-3468.14842.

ヒト脂肪肝モデル細胞に関する論文のご案内

弊社研究員の高橋より、ヒト脂肪肝モデル細胞(PXB-cells LA)に関する論文が発表されましたので、ご案内いたします。

Development of an effective single-chain variable fragment recognizing a novel epitope in the hepatitis C virus E2 protein that restricts virus entry into hepatocytes

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38683226

Das, S. Behera, P. Shewale, D. J. Bodele, J. Das, S. Karande, A. A.
Arch Virol. 2024 Apr 29;169(5):112. doi: 10.1007/s00705-024-06024-4.

A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38315437

Watanabe, T. Hayashi, S. Zhaoyu, Y. Inada, H. Nagaoka, K. Tateyama, M. Tanaka, Y.
J Gastroenterol. 2024 Apr;59(4):315-328. doi: 10.1007/s00535-023-02070-y. Epub 2024 Feb 5.

Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38384383

Kurniawan, D. A. Leo, S. Inamatsu, M. Funaoka, S. Aihara, T. Aiko, M. Rei, I. Sakura, T. Arakawa, H. Kato, Y. Matsugi, T. Esashika, K. Shiraki, N. Kume, S. Shinha, K. Kimura, H. Nishikawa, M. Sakai, Y.
PNAS Nexus. 2024 Feb 9;3(2):pgae070. doi: 10.1093/pnasnexus/pgae070. eCollection 2024 Feb.

Multi-omics analysis of a fatty liver model using human hepatocyte chimeric mice

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38336825

Ichikawa, A. Miki, D. Hayes, C. N. Teraoka, Y. Nakahara, H. Tateno, C. Ishida, Y. Chayama, K. Oka, S.
Sci Rep. 2024 Feb 9;14(1):3362. doi: 10.1038/s41598-024-53890-8.

Nucleos(t)ide analogs for hepatitis B virus infection differentially regulate the growth factor signaling in hepatocytes

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38180972

Shimizu, R. Murai, K. Tanaka, K. Sato, Y. Takeda, N. Nakasyo, S. Shirasaki, T. Kawaguchi, K. Shimakami, T. Nio, K. Nakaya, Y. Kagiwada, H. Horimoto, K. Mizokami, M. Kaneko, S. Murata, K. Yamashita, T. Honda, M.
Hepatol Commun. 2024 Jan 5;8(1):e0351. doi: 10.1097/HC9.0000000000000351. eCollection 2024 Jan 1.

Hepatitis B virus evades the immune system by suppressing the NF-kappaB signaling pathway with DENND2A

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/38240571

Ide, M. Tabata, N. Yonemura, Y. Murai, K. Wang, Y. Ishida, A. Honda, M. Kaneko, S. Ito, S. Yanagawa, H.
Microbiol Spectr. 2024 Jan 19:e0378523. doi: 10.1128/spectrum.03785-23.