Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-treated Liver-Humanized PXB Mice

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31550900

King, A. Baginski, M. Morikawa, Y. Rainville, P. D. Gethings, L. A. Wilson, I. D. Plumb, R. S.

J Proteome Res. 2019 Oct 8. doi: 10.1021/acs.jproteome.9b00334..

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31393263

Katsuda, T. Matsuzaki, J. Yamaguchi, T. Yamada, Y. Prieto-Vila, M. Hosaka, K. Takeuchi, A. Saito, Y. Ochiya, T.

Elife. 2019 Aug 8;8. pii: 47313. doi: 10.7554/eLife.47313.

Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31199224

Osawa, M. Uchida, T. Imamura, M. Teraoka, Y. Fujino, H. Nakahara, T. Ono, A. Murakami, E. Kawaoka, T. Miki, D. Tsuge, M. Hiramatsu, A. Abe-Chayama, H. Hayes, C. N.

J Gen Virol. 2019 Jul;100(7):1123-1131.

Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/30905707

Takehara, I. Watanabe, N. Mori, D. Ando, O. Kusuhara, H.

J Pharm Sci. 2019 Mar 21.

Anti-HBV activity of retinoid drugs in vitro versus in vivo

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31226346

Birkus, G. Snyder, C. Jordan, R. Kobayashi, T. Dick, R. Puscau, V. Li, L. Ramirez, R. Willkom, M. Morikawa, Y. Delaney, W. Schmitz, U.

Antiviral Res. 2019 Jun 18:104538. doi: 10.1016/j.antiviral.2019.104538.

An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31188831

Furutani, Y. Toguchi, M. Shiozaki-Sato, Y. Qin, X. Y. Ebisui, E. Higuchi, S. Sudoh, M. Suzuki, H. Takahashi, N. Watashi, K. Wakita, T. Kakeya, H. Kojima, S.

PLoS One. 2019 Jun 12;14(6):e0216139. doi: 10.1371/journal.pone.0216139. eCollection 2019.

Humanized Mouse Models for the Study of Hepatitis C and Host Interactions

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31213010

Yong, K. S. M. Her, Z. Chen, Q.

Cells. 2019 Jun 17;8(6). pii: cells8060604.

Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with in Vitro-in Vivo Extrapolation and Allometric Scaling

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/30828063

Naritomi, Y. Sanoh, S. Ohta, S.

Biol Pharm Bull. 2019;42(3):327-336. doi: 10.1248/bpb.b18-00754.

Mice with Chimeric Human Livers and Their Applications

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/30593646

Douglas, D. N. Kneteman, N. M.

Methods Mol Biol. 2019;1911:459-479.

Study of the Metabolism of New Drugs of Abuse

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31061338

Kanamori, T.

Yakugaku Zasshi. 2019;139(5):699-704. doi: 10.1248/yakushi.18-00166-3.

Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver

Seigo Sanoh*,a, Yuka Tamuraa, Chieri Fujinoa, Go Sugaharab, Yasumi Yoshizaneb, Ami Yanagib, Keishi Kisohb, Yuji Ishidab,c, Chise Tatenob,c, Shigeru Ohtaa,d, and Yaichiro Kotakea.

BPB Reports

Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31097716

Kang, J. A. Kim, S. Park, M. Park, H. J. Kim, J. H. Park, S. Hwang, J. R. Kim, Y. C. Jun Kim, Y. Cho, Y. Sun Jin, M. Park, S. G.

Nat Commun. 2019 May 16;10(1):2184. doi: 10.1038/s41467-019-10200-5.

Changes in Bile Acid Concentrations in Chimeric Mice Transplanted with Different Replacement Indexes of Human Hepatocytes

• Pub Med URL https://www3.e-kenkyu.com/bpb-reports-online-journal/authors/13

Chieri Fujino,a Seigo Sanoh,*,a Yuka Tamura,a Yuji Ishida,b,c Chise Tateno,b,c Shigeru Ohta,a,d and Yaichiro Kotakea.

BPB Reports 2, 29-34 (2019)

Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of HCV-infected Cells and Liver to Identify Pathways Associated With Disease Development

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/30978357

Lupberger, J. Croonenborghs, T. Roca Suarez, A. A. Van Renne, N. Juhling, F. Oudot, M. A. Virzi, A. Bandiera, S. Jamey, C. Meszaros, G. Brumaru, D. Mukherji, A. Durand, S. C. Heydmann, L. Verrier, E. R. El Saghire, H. Hamdane, N. Bartenschlager, R. Fereshetian, S. Ramberger, E. Sinha, R. Nabian, M. Everaert, C. Jovanovic, M. Mertins, P. Carr, S. A. Chayama, K. Dali-Youcef, N. Ricci, R. Bardeesy, N. M. Fujiwara, N. Gevaert, O. Zeisel, M. B. Hoshida, Y. Pochet, N. Baumert, T. F.

Gastroenterology. 2019 Apr 9. pii: S0016-5085(19)35670-7. doi: 10.1053/j.gastro.2019.04.003.

Metabolism of Butyrylfentanyl in Fresh Human Hepatocytes: Chemical Synthesis of Authentic Metabolite Standards for Definitive Identification

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/30930421

Kanamori, T. Iwata, Y. T. Segawa, H. Yamamuro, T. Kuwayama, K. Tsujikawa, K. Inoue, H.

Biol Pharm Bull. 2019;42(4):623-630. doi: 10.1248/bpb.b18-00765.

Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/29619871

Nakayama, K. Ito, S. Suzuki, M. Takubo, H. Yamazaki, H. Nomura, Y.

Xenobiotica. 2019 Apr; 49(4):404-414.  doi:10.1080/00498254.2018.1460516. Epub 2018 Apr 19.

PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/30365161

Mueller, H. Lopez, A. Tropberger, P. Wildum, S. Schmaler, J. Pedersen, L. Han, X. Wang, Y. Ottosen, S. Yang, S. Young, J. A. T. Javanbakht, H.

Hepatology. 2019 Apr;69(4):1398-1411. doi: 10.1002/hep.30329. Epub 2019 Mar 1.

HCV-induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/30836093

Hamdane, N. Juhling, F. Crouchet, E. El Saghire, H. Thumann, C. Oudot, M. A. Bandiera, S. Saviano, A. Ponsolles, C. Roca Suarez, A. A. Li, S. Fujiwara, N. Ono, A. Davidson, I. Bardeesy, N. Schmidl, C. Bock, C. Schuster, C. Lupberger, J. Habersetzer, F. Doffoel, M. Piardi, T. Sommacale, D. mamura, M. Uchida, T. Ohdan, H. Aikata, H. Chayama, K. Boldanova, T. Pessaux, P. Fuchs, B. C. Hoshida, Y. Zeisel, M. B. Duong, F. H. T. Baumert, T. F.

Gastroenterology. 2019 Mar 2. pii: S0016-5085(19)32506-5. doi: 10.1053/j.gastro.2019.02.038.

An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/29893492

Hayashi, S. Khan, A. Simons, B. C. Homan, C. Matsui, T. Ogawa, K. Kawashima, K. Murakami, S. Takahashi, S. Isogawa, M. Ikeo, K. Mizokami, M. McMahon, B. J. Tanaka, Y.

Hepatology. 2019 Jan;69(1):19-33. doi: 10.1002/hep.30111. Epub 2018 Dec 10.

Hepatic IFN-Induced Protein with Tetratricopeptide Repeats Regulation of HCV Infection

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/30844328

Ishida, Y. Kakuni, M. Bang, B. R. Sugahara, G. Lau, D. T. Tateno-Mukaidani, C. Li, M. Gale, M., Jr. Saito, T.

J Interferon Cytokine Res. 2019 Mar;39(3):133-146. doi: 10.1089/jir.2018.0103.