Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

2020/06/17

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/32071686

Steeneck, C. Kinzel, O. Anderhub, S. Hornberger, M. Pinto, S. Morschhaeuser, B. Braun, F. Kleymann, G. Hoffmann, T.

ACS Med Chem Lett. 2020 Jan 27;11(2):179-187. doi: 10.1021/acsmedchemlett.9b00572. eCollection 2020 Feb 13.

VIEW AS PDF

Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: Integration with hepatic drug metabolism

2020/06/17

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/32401667

Sanoh, S. Naritomi, Y. Kitamura, S. Shinagawa, A. Kakuni, M. Tateno, C. Ohta, S.

Xenobiotica. 2020 Jun 5:1-10. doi: 10.1080/00498254.2020.1769229.

VIEW AS PDF

A novel evaluation method for determining drug-induced hepatotoxicity using 3D bio-printed human liver tissue

2020/06/17

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31736396

Ide, I. Nagao, E. Kajiyama, S. Mizoguchi, N.

Toxicol Mech Methods. 2020 Mar;30(3):189-196. doi: 10.1080/15376516.2019.1686795. Epub 2019 Nov 21.

VIEW AS PDF

Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus

2020/06/17

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/32105634

Matsunaga, S. Jeremiah, S. S. Miyakawa, K. Kurotaki, D. Shizukuishi, S. Watashi, K. Nishitsuji, H. Kimura, H. Tamura, T. Yamamoto, N. Shimotohno, K. Wakita, T. Ryo, A.

iScience. 2020 Mar 27;23(3):100867. doi: 10.1016/j.isci.2020.100867. Epub 2020 Feb 26.

VIEW AS PDF

Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir

2020/06/17

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/32345577

Wang, T. Babusis, D. Park, Y. Niu, C. Kim, C. Zhao, X. Lu, B. Ma, B. Muench, R. C. Sperger, D. Ray, A. S. Murakami, E.

Drug Metab Pharmacokinet. 2020 Jun;35(3):334-340. doi: 10.1016/j.dmpk.2020.04.333. Epub 2020 Apr 16.

VIEW AS PDF

Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

2020/04/14

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/32074631

Sugahara, G. Ishida, Y. Sun, J. Tateno, C. Saito, T.

Semin Liver Dis. 2020 Feb 19. doi: 10.1055/s-0040-1701444.

VIEW AS PDF

Characterization and applications of chimeric mice with humanized livers for preclinical drug development

2020/04/14

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/32206609

Tateno, Chise; Kojima, Yuha

Laboratory Animal Research volume 36, Article number: 2 (2020)

VIEW AS PDF

Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

2020/04/14

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/32163375

Cheng, X. Uchida, T. Xia, Y. Umarova, R. Liu, C. J. Chen, P. J. Gaggar, A. Suri, V. Mucke, M. M. Vermehren, J. Zeuzem, S. Teraoka, Y. Osawa, M. Aikata, H. Tsuji, K. Mori, N. Hige, S. Karino, Y. Imamura, M. Chayama, K. Liang, T. J.

J Clin Invest. 2020 Mar 12. pii: 135616. doi: 10.1172/JCI135616.

VIEW AS PDF

Lipoprotein profile and lipid metabolism of PXB-cells((R)), human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs

2020/04/14

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/32092738

Hata, K. Sayaka, T. Takahashi, M. Sasaki, A. Umekawa, Y. Miyashita, K. Ogura, K. Toshima, G. Maeda, M. Takahashi, J. Kakuni, M.

Biomed Res. 2020;41(1):33-42. doi: 10.2220/biomedres.41.33.

VIEW AS PDF

Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver

2020/04/14

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31991145

Ikeyama, Y. Sato, T. Takemura, A. Sekine, S. Ito, K.

Toxicol In Vitro. 2020 Jan 25:104785. doi: 10.1016/j.tiv.2020.104785.

VIEW AS PDF

High-throughput screening to evaluate inhibition of bile acid transporters using human hepatocytes isolated from chimeric mice

2019/11/28

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31722436

Kohara, H. Bajaj, P. Yamanaka, K. Miyawaki, A. Harada, K. Miyamoto, K. Matsui, T. Okai, Y. Wagoner, M. Shinozawa, T.

Toxicol Sci. 2019 Nov 13. pii: 5625164. doi: 10.1093/toxsci/kfz229.

VIEW AS PDF

Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-treated Liver-Humanized PXB Mice

2019/11/28

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31550900

King, A. Baginski, M. Morikawa, Y. Rainville, P. D. Gethings, L. A. Wilson, I. D. Plumb, R. S.

J Proteome Res. 2019 Oct 8. doi: 10.1021/acs.jproteome.9b00334..

VIEW AS PDF

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

2019/11/28

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31393263

Katsuda, T. Matsuzaki, J. Yamaguchi, T. Yamada, Y. Prieto-Vila, M. Hosaka, K. Takeuchi, A. Saito, Y. Ochiya, T.

Elife. 2019 Aug 8;8. pii: 47313. doi: 10.7554/eLife.47313.

VIEW AS PDF

Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice

2019/11/28

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31199224

Osawa, M. Uchida, T. Imamura, M. Teraoka, Y. Fujino, H. Nakahara, T. Ono, A. Murakami, E. Kawaoka, T. Miki, D. Tsuge, M. Hiramatsu, A. Abe-Chayama, H. Hayes, C. N.

J Gen Virol. 2019 Jul;100(7):1123-1131.

VIEW AS PDF

Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

2019/11/28

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/30905707

Takehara, I. Watanabe, N. Mori, D. Ando, O. Kusuhara, H.

J Pharm Sci. 2019 Mar 21.

VIEW AS PDF

Anti-HBV activity of retinoid drugs in vitro versus in vivo

2019/11/28

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31226346

Birkus, G. Snyder, C. Jordan, R. Kobayashi, T. Dick, R. Puscau, V. Li, L. Ramirez, R. Willkom, M. Morikawa, Y. Delaney, W. Schmitz, U.

Antiviral Res. 2019 Jun 18:104538. doi: 10.1016/j.antiviral.2019.104538.

VIEW AS PDF

An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes

2019/11/28

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/31188831

Furutani, Y. Toguchi, M. Shiozaki-Sato, Y. Qin, X. Y. Ebisui, E. Higuchi, S. Sudoh, M. Suzuki, H. Takahashi, N. Watashi, K. Wakita, T. Kakeya, H. Kojima, S.

PLoS One. 2019 Jun 12;14(6):e0216139. doi: 10.1371/journal.pone.0216139. eCollection 2019.

VIEW AS PDF